Lactic acidosis causes: Difference between revisions
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==Overview== | ==Overview== | ||
Lactic acidosis is one of the most common causes of high [[anion gap]] [[metabolic acidosis]] and is usually associated with a serum [[lactate]] levels above 4 mmol/L. Reduced oxygen tension shunts [[glycolysis]] towards [[pyruvate]] production, which in turn leads to lactate accumulation since pyruvate can no longer undergo [[aerobic metabolism]]. | Lactic acidosis is one of the most common causes of high [[anion gap]] [[metabolic acidosis]] and is usually associated with a serum [[lactate]] levels above 4 mmol/L. Reduced oxygen tension shunts [[glycolysis]] towards [[pyruvate]] production, which in turn leads to lactate accumulation since pyruvate can no longer undergo [[aerobic metabolism]]. | ||
==Causes== | ==Causes== | ||
===Life Threatening Causes=== | ===Life Threatening Causes=== | ||
Life-threatening causes include conditions which result in death or permanent disability within 24 hours if left untreated. | |||
*[[Cardiac arrest]] | *[[Cardiac arrest]] | ||
*[[Mesenteric ischemia]] | *[[Mesenteric ischemia]] | ||
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==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Crowdiagnosis]] | |||
[[Category:Electrolyte disturbance]] | [[Category:Electrolyte disturbance]] | ||
[[Category:Medical emergencies]] | [[Category:Medical emergencies]] | ||
Revision as of 04:38, 20 August 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Lactic acidosis is one of the most common causes of high anion gap metabolic acidosis and is usually associated with a serum lactate levels above 4 mmol/L. Reduced oxygen tension shunts glycolysis towards pyruvate production, which in turn leads to lactate accumulation since pyruvate can no longer undergo aerobic metabolism.
Causes
Life Threatening Causes
Life-threatening causes include conditions which result in death or permanent disability within 24 hours if left untreated.
Common Causes
- Alcoholism
- Carbon monoxide poisoning
- Cyanide poisoning
- Exercise
- Grand mal seizure
- Hypoglycemia
- Hypoxemia
- Malignancy
- Metformin
- Pheochromocytoma
- Pulmonary edema
- Salicylate intoxication
- Stavudine
- Zidovudine
Causes by Organ System
Causes by Organ System developed by WikiDoc.org, Copyleft 2013