Idiopathic interstitial pneumonia natural history, complications and prognosis: Difference between revisions
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==Biomarkers== | ==Biomarkers== | ||
The functional lung capacity, pulmonary functions and mortality have been linked to some biomarkers. This Table summarizes the findings of different research studies. | The functional lung capacity, pulmonary functions and mortality have been linked to some biomarkers. | ||
This Table summarizes the findings of different research studies. | |||
<ref name="Takahashi-2000">{{Cite journal | last1 = Takahashi | first1 = H. | last2 = Fujishima | first2 = T. | last3 = Koba | first3 = H. | last4 = Murakami | first4 = S. | last5 = Kurokawa | first5 = K. | last6 = Shibuya | first6 = Y. | last7 = Shiratori | first7 = M. | last8 = Kuroki | first8 = Y. | last9 = Abe | first9 = S. | title = Serum surfactant proteins A and D as prognostic factors in idiopathic pulmonary fibrosis and their relationship to disease extent. | journal = Am J Respir Crit Care Med | volume = 162 | issue = 3 Pt 1 | pages = 1109-14 | month = Sep | year = 2000 | doi = 10.1164/ajrccm.162.3.9910080 | PMID = 10988138 }}</ref> <ref name="Greene-2002">{{Cite journal | last1 = Greene | first1 = KE. | last2 = King | first2 = TE. | last3 = Kuroki | first3 = Y. | last4 = Bucher-Bartelson | first4 = B. | last5 = Hunninghake | first5 = GW. | last6 = Newman | first6 = LS. | last7 = Nagae | first7 = H. | last8 = Mason | first8 = RJ. | title = Serum surfactant proteins-A and -D as biomarkers in idiopathic pulmonary fibrosis. | journal = Eur Respir J | volume = 19 | issue = 3 | pages = 439-46 | month = Mar | year = 2002 | doi = | PMID = 11936520 }}</ref> <ref name="Yokoyama-2006">{{Cite journal | last1 = Yokoyama | first1 = A. | last2 = Kondo | first2 = K. | last3 = Nakajima | first3 = M. | last4 = Matsushima | first4 = T. | last5 = Takahashi | first5 = T. | last6 = Nishimura | first6 = M. | last7 = Bando | first7 = M. | last8 = Sugiyama | first8 = Y. | last9 = Totani | first9 = Y. | title = Prognostic value of circulating KL-6 in idiopathic pulmonary fibrosis. | journal = Respirology | volume = 11 | issue = 2 | pages = 164-8 | month = Mar | year = 2006 | doi = 10.1111/j.1440-1843.2006.00834.x | PMID = 16548901 }}</ref> <ref name="Satoh-2006">{{Cite journal | last1 = Satoh | first1 = H. | last2 = Kurishima | first2 = K. | last3 = Ishikawa | first3 = H. | last4 = Ohtsuka | first4 = M. | title = Increased levels of KL-6 and subsequent mortality in patients with interstitial lung diseases. | journal = J Intern Med | volume = 260 | issue = 5 | pages = 429-34 | month = Nov | year = 2006 | doi = 10.1111/j.1365-2796.2006.01704.x | PMID = 17040248 }}</ref> <ref name="Takahashi-2006">{{Cite journal | last1 = Takahashi | first1 = H. | last2 = Shiratori | first2 = M. | last3 = Kanai | first3 = A. | last4 = Chiba | first4 = H. | last5 = Kuroki | first5 = Y. | last6 = Abe | first6 = S. | title = Monitoring markers of disease activity for interstitial lung diseases with serum surfactant proteins A and D. | journal = Respirology | volume = 11 Suppl | issue = | pages = S51-4 | month = Jan | year = 2006 | doi = 10.1111/j.1440-1843.2006.00809.x | PMID = 16423272 }}</ref> <ref name="Daniil-2008">{{Cite journal | last1 = Daniil | first1 = ZD. | last2 = Papageorgiou | first2 = E. | last3 = Koutsokera | first3 = A. | last4 = Kostikas | first4 = K. | last5 = Kiropoulos | first5 = T. | last6 = Papaioannou | first6 = AI. | last7 = Gourgoulianis | first7 = KI. | title = Serum levels of oxidative stress as a marker of disease severity in idiopathic pulmonary fibrosis. | journal = Pulm Pharmacol Ther | volume = 21 | issue = 1 | pages = 26-31 | month = | year = 2008 | doi = 10.1016/j.pupt.2006.10.005 | PMID = 17161968 }}</ref> <ref name="Rosas-2008">{{Cite journal | last1 = Rosas | first1 = IO. | last2 = Richards | first2 = TJ. | last3 = Konishi | first3 = K. | last4 = Zhang | first4 = Y. | last5 = Gibson | first5 = K. | last6 = Lokshin | first6 = AE. | last7 = Lindell | first7 = KO. | last8 = Cisneros | first8 = J. | last9 = Macdonald | first9 = SD. | title = MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis. | journal = PLoS Med | volume = 5 | issue = 4 | pages = e93 | month = Apr | year = 2008 | doi = 10.1371/journal.pmed.0050093 | PMID = 18447576 }}</ref> <ref name="Kinder-2009">{{Cite journal | last1 = Kinder | first1 = BW. | last2 = Brown | first2 = KK. | last3 = McCormack | first3 = FX. | last4 = Ix | first4 = JH. | last5 = Kervitsky | first5 = A. | last6 = Schwarz | first6 = MI. | last7 = King | first7 = TE. | title = Serum surfactant protein-A is a strong predictor of early mortality in idiopathic pulmonary fibrosis. | journal = Chest | volume = 135 | issue = 6 | pages = 1557-63 | month = Jun | year = 2009 | doi = 10.1378/chest.08-2209 | PMID = 19255294 }}</ref> <ref name="Barlo-2009">{{Cite journal | last1 = Barlo | first1 = NP. | last2 = van Moorsel | first2 = CH. | last3 = Ruven | first3 = HJ. | last4 = Zanen | first4 = P. | last5 = van den Bosch | first5 = JM. | last6 = Grutters | first6 = JC. | title = Surfactant protein-D predicts survival in patients with idiopathic pulmonary fibrosis. | journal = Sarcoidosis Vasc Diffuse Lung Dis | volume = 26 | issue = 2 | pages = 155-61 | month = Jul | year = 2009 | doi = | PMID = 20560296 }}</ref> <ref name="Prasse-2007">{{Cite journal | last1 = Prasse | first1 = A. | last2 = Pechkovsky | first2 = DV. | last3 = Toews | first3 = GB. | last4 = Schäfer | first4 = M. | last5 = Eggeling | first5 = S. | last6 = Ludwig | first6 = C. | last7 = Germann | first7 = M. | last8 = Kollert | first8 = F. | last9 = Zissel | first9 = G. | title = CCL18 as an indicator of pulmonary fibrotic activity in idiopathic interstitial pneumonias and systemic sclerosis. | journal = Arthritis Rheum | volume = 56 | issue = 5 | pages = 1685-93 | month = May | year = 2007 | doi = 10.1002/art.22559 | PMID = 17469163 }}</ref> <ref name="Gilani-2010">{{Cite journal | last1 = Gilani | first1 = SR. | last2 = Vuga | first2 = LJ. | last3 = Lindell | first3 = KO. | last4 = Gibson | first4 = KF. | last5 = Xue | first5 = J. | last6 = Kaminski | first6 = N. | last7 = Valentine | first7 = VG. | last8 = Lindsay | first8 = EK. | last9 = George | first9 = MP. | title = CD28 down-regulation on circulating CD4 T-cells is associated with poor prognoses of patients with idiopathic pulmonary fibrosis. | journal = PLoS One | volume = 5 | issue = 1 | pages = e8959 | month = | year = 2010 | doi = 10.1371/journal.pone.0008959 | PMID = 20126467 }}</ref> <ref name="Richards-2012">{{Cite journal | last1 = Richards | first1 = TJ. | last2 = Kaminski | first2 = N. | last3 = Baribaud | first3 = F. | last4 = Flavin | first4 = S. | last5 = Brodmerkel | first5 = C. | last6 = Horowitz | first6 = D. | last7 = Li | first7 = K. | last8 = Choi | first8 = J. | last9 = Vuga | first9 = LJ. | title = Peripheral blood proteins predict mortality in idiopathic pulmonary fibrosis. | journal = Am J Respir Crit Care Med | volume = 185 | issue = 1 | pages = 67-76 | month = Jan | year = 2012 | doi = 10.1164/rccm.201101-0058OC | PMID = 22016448 }}</ref> <ref name="McKeown-2009">{{Cite journal | last1 = McKeown | first1 = S. | last2 = Richter | first2 = AG. | last3 = O'Kane | first3 = C. | last4 = McAuley | first4 = DF. | last5 = Thickett | first5 = DR. | title = MMP expression and abnormal lung permeability are important determinants of outcome in IPF. | journal = Eur Respir J | volume = 33 | issue = 1 | pages = 77-84 | month = Jan | year = 2009 | doi = 10.1183/09031936.00060708 | PMID = 18829682 }}</ref> <ref name="Shinoda-2009">{{Cite journal | last1 = Shinoda | first1 = H. | last2 = Tasaka | first2 = S. | last3 = Fujishima | first3 = S. | last4 = Yamasawa | first4 = W. | last5 = Miyamoto | first5 = K. | last6 = Nakano | first6 = Y. | last7 = Kamata | first7 = H. | last8 = Hasegawa | first8 = N. | last9 = Ishizaka | first9 = A. | title = Elevated CC chemokine level in bronchoalveolar lavage fluid is predictive of a poor outcome of idiopathic pulmonary fibrosis. | journal = Respiration | volume = 78 | issue = 3 | pages = 285-92 | month = | year = 2009 | doi = 10.1159/000207617 | PMID = 19270434 }}</ref> <ref name="Richter-2009">{{Cite journal | last1 = Richter | first1 = AG. | last2 = McKeown | first2 = S. | last3 = Rathinam | first3 = S. | last4 = Harper | first4 = L. | last5 = Rajesh | first5 = P. | last6 = McAuley | first6 = DF. | last7 = Heljasvaara | first7 = R. | last8 = Thickett | first8 = DR. | title = Soluble endostatin is a novel inhibitor of epithelial repair in idiopathic pulmonary fibrosis. | journal = Thorax | volume = 64 | issue = 2 | pages = 156-61 | month = Feb | year = 2009 | doi = 10.1136/thx.2008.102814 | PMID = 18852160 }}</ref> | [[File:Biomarkers in IIPS.png|300px]] | ||
<ref name="Takahashi-2000">{{Cite journal | last1 = Takahashi | first1 = H. | last2 = Fujishima | first2 = T. | last3 = Koba | first3 = H. | last4 = Murakami | first4 = S. | last5 = Kurokawa | first5 = K. | last6 = Shibuya | first6 = Y. | last7 = Shiratori | first7 = M. | last8 = Kuroki | first8 = Y. | last9 = Abe | first9 = S. | title = Serum surfactant proteins A and D as prognostic factors in idiopathic pulmonary fibrosis and their relationship to disease extent. | journal = Am J Respir Crit Care Med | volume = 162 | issue = 3 Pt 1 | pages = 1109-14 | month = Sep | year = 2000 | doi = 10.1164/ajrccm.162.3.9910080 | PMID = 10988138 }}</ref> <ref name="Greene-2002">{{Cite journal | last1 = Greene | first1 = KE. | last2 = King | first2 = TE. | last3 = Kuroki | first3 = Y. | last4 = Bucher-Bartelson | first4 = B. | last5 = Hunninghake | first5 = GW. | last6 = Newman | first6 = LS. | last7 = Nagae | first7 = H. | last8 = Mason | first8 = RJ. | title = Serum surfactant proteins-A and -D as biomarkers in idiopathic pulmonary fibrosis. | journal = Eur Respir J | volume = 19 | issue = 3 | pages = 439-46 | month = Mar | year = 2002 | doi = | PMID = 11936520 }}</ref> <ref name="Yokoyama-2006">{{Cite journal | last1 = Yokoyama | first1 = A. | last2 = Kondo | first2 = K. | last3 = Nakajima | first3 = M. | last4 = Matsushima | first4 = T. | last5 = Takahashi | first5 = T. | last6 = Nishimura | first6 = M. | last7 = Bando | first7 = M. | last8 = Sugiyama | first8 = Y. | last9 = Totani | first9 = Y. | title = Prognostic value of circulating KL-6 in idiopathic pulmonary fibrosis. | journal = Respirology | volume = 11 | issue = 2 | pages = 164-8 | month = Mar | year = 2006 | doi = 10.1111/j.1440-1843.2006.00834.x | PMID = 16548901 }}</ref> <ref name="Satoh-2006">{{Cite journal | last1 = Satoh | first1 = H. | last2 = Kurishima | first2 = K. | last3 = Ishikawa | first3 = H. | last4 = Ohtsuka | first4 = M. | title = Increased levels of KL-6 and subsequent mortality in patients with interstitial lung diseases. | journal = J Intern Med | volume = 260 | issue = 5 | pages = 429-34 | month = Nov | year = 2006 | doi = 10.1111/j.1365-2796.2006.01704.x | PMID = 17040248 }}</ref> <ref name="Takahashi-2006">{{Cite journal | last1 = Takahashi | first1 = H. | last2 = Shiratori | first2 = M. | last3 = Kanai | first3 = A. | last4 = Chiba | first4 = H. | last5 = Kuroki | first5 = Y. | last6 = Abe | first6 = S. | title = Monitoring markers of disease activity for interstitial lung diseases with serum surfactant proteins A and D. | journal = Respirology | volume = 11 Suppl | issue = | pages = S51-4 | month = Jan | year = 2006 | doi = 10.1111/j.1440-1843.2006.00809.x | PMID = 16423272 }}</ref> <ref name="Daniil-2008">{{Cite journal | last1 = Daniil | first1 = ZD. | last2 = Papageorgiou | first2 = E. | last3 = Koutsokera | first3 = A. | last4 = Kostikas | first4 = K. | last5 = Kiropoulos | first5 = T. | last6 = Papaioannou | first6 = AI. | last7 = Gourgoulianis | first7 = KI. | title = Serum levels of oxidative stress as a marker of disease severity in idiopathic pulmonary fibrosis. | journal = Pulm Pharmacol Ther | volume = 21 | issue = 1 | pages = 26-31 | month = | year = 2008 | doi = 10.1016/j.pupt.2006.10.005 | PMID = 17161968 }}</ref> <ref name="Rosas-2008">{{Cite journal | last1 = Rosas | first1 = IO. | last2 = Richards | first2 = TJ. | last3 = Konishi | first3 = K. | last4 = Zhang | first4 = Y. | last5 = Gibson | first5 = K. | last6 = Lokshin | first6 = AE. | last7 = Lindell | first7 = KO. | last8 = Cisneros | first8 = J. | last9 = Macdonald | first9 = SD. | title = MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis. | journal = PLoS Med | volume = 5 | issue = 4 | pages = e93 | month = Apr | year = 2008 | doi = 10.1371/journal.pmed.0050093 | PMID = 18447576 }}</ref> <ref name="Kinder-2009">{{Cite journal | last1 = Kinder | first1 = BW. | last2 = Brown | first2 = KK. | last3 = McCormack | first3 = FX. | last4 = Ix | first4 = JH. | last5 = Kervitsky | first5 = A. | last6 = Schwarz | first6 = MI. | last7 = King | first7 = TE. | title = Serum surfactant protein-A is a strong predictor of early mortality in idiopathic pulmonary fibrosis. | journal = Chest | volume = 135 | issue = 6 | pages = 1557-63 | month = Jun | year = 2009 | doi = 10.1378/chest.08-2209 | PMID = 19255294 }}</ref> <ref name="Barlo-2009">{{Cite journal | last1 = Barlo | first1 = NP. | last2 = van Moorsel | first2 = CH. | last3 = Ruven | first3 = HJ. | last4 = Zanen | first4 = P. | last5 = van den Bosch | first5 = JM. | last6 = Grutters | first6 = JC. | title = Surfactant protein-D predicts survival in patients with idiopathic pulmonary fibrosis. | journal = Sarcoidosis Vasc Diffuse Lung Dis | volume = 26 | issue = 2 | pages = 155-61 | month = Jul | year = 2009 | doi = | PMID = 20560296 }}</ref> <ref name="Prasse-2007">{{Cite journal | last1 = Prasse | first1 = A. | last2 = Pechkovsky | first2 = DV. | last3 = Toews | first3 = GB. | last4 = Schäfer | first4 = M. | last5 = Eggeling | first5 = S. | last6 = Ludwig | first6 = C. | last7 = Germann | first7 = M. | last8 = Kollert | first8 = F. | last9 = Zissel | first9 = G. | title = CCL18 as an indicator of pulmonary fibrotic activity in idiopathic interstitial pneumonias and systemic sclerosis. | journal = Arthritis Rheum | volume = 56 | issue = 5 | pages = 1685-93 | month = May | year = 2007 | doi = 10.1002/art.22559 | PMID = 17469163 }}</ref> <ref name="Gilani-2010">{{Cite journal | last1 = Gilani | first1 = SR. | last2 = Vuga | first2 = LJ. | last3 = Lindell | first3 = KO. | last4 = Gibson | first4 = KF. | last5 = Xue | first5 = J. | last6 = Kaminski | first6 = N. | last7 = Valentine | first7 = VG. | last8 = Lindsay | first8 = EK. | last9 = George | first9 = MP. | title = CD28 down-regulation on circulating CD4 T-cells is associated with poor prognoses of patients with idiopathic pulmonary fibrosis. | journal = PLoS One | volume = 5 | issue = 1 | pages = e8959 | month = | year = 2010 | doi = 10.1371/journal.pone.0008959 | PMID = 20126467 }}</ref> <ref name="Richards-2012">{{Cite journal | last1 = Richards | first1 = TJ. | last2 = Kaminski | first2 = N. | last3 = Baribaud | first3 = F. | last4 = Flavin | first4 = S. | last5 = Brodmerkel | first5 = C. | last6 = Horowitz | first6 = D. | last7 = Li | first7 = K. | last8 = Choi | first8 = J. | last9 = Vuga | first9 = LJ. | title = Peripheral blood proteins predict mortality in idiopathic pulmonary fibrosis. | journal = Am J Respir Crit Care Med | volume = 185 | issue = 1 | pages = 67-76 | month = Jan | year = 2012 | doi = 10.1164/rccm.201101-0058OC | PMID = 22016448 }}</ref> <ref name="McKeown-2009">{{Cite journal | last1 = McKeown | first1 = S. | last2 = Richter | first2 = AG. | last3 = O'Kane | first3 = C. | last4 = McAuley | first4 = DF. | last5 = Thickett | first5 = DR. | title = MMP expression and abnormal lung permeability are important determinants of outcome in IPF. | journal = Eur Respir J | volume = 33 | issue = 1 | pages = 77-84 | month = Jan | year = 2009 | doi = 10.1183/09031936.00060708 | PMID = 18829682 }}</ref> <ref name="Shinoda-2009">{{Cite journal | last1 = Shinoda | first1 = H. | last2 = Tasaka | first2 = S. | last3 = Fujishima | first3 = S. | last4 = Yamasawa | first4 = W. | last5 = Miyamoto | first5 = K. | last6 = Nakano | first6 = Y. | last7 = Kamata | first7 = H. | last8 = Hasegawa | first8 = N. | last9 = Ishizaka | first9 = A. | title = Elevated CC chemokine level in bronchoalveolar lavage fluid is predictive of a poor outcome of idiopathic pulmonary fibrosis. | journal = Respiration | volume = 78 | issue = 3 | pages = 285-92 | month = | year = 2009 | doi = 10.1159/000207617 | PMID = 19270434 }}</ref> <ref name="Richter-2009">{{Cite journal | last1 = Richter | first1 = AG. | last2 = McKeown | first2 = S. | last3 = Rathinam | first3 = S. | last4 = Harper | first4 = L. | last5 = Rajesh | first5 = P. | last6 = McAuley | first6 = DF. | last7 = Heljasvaara | first7 = R. | last8 = Thickett | first8 = DR. | title = Soluble endostatin is a novel inhibitor of epithelial repair in idiopathic pulmonary fibrosis. | journal = Thorax | volume = 64 | issue = 2 | pages = 156-61 | month = Feb | year = 2009 | doi = 10.1136/thx.2008.102814 | PMID = 18852160 }}</ref>. | |||
Rapidly deteriorating lung function and higher mortality have been associated with high serum level of epithelial or macrophage-related proteins such as SP-A, SP-D, KL-6 (Krebs von den Lungen-6), CCL18 (chemokine ligand-18), and MMP-7 (matrix metalloproteinase-7) <ref name="Satoh-2006">{{Cite journal | last1 = Satoh | first1 = H. | last2 = Kurishima | first2 = K. | last3 = Ishikawa |first3 = H. | last4 = Ohtsuka | first4 = M. | title = Increased levels of KL-6 and subsequent mortality in patients with interstitial lung diseases. |journal = J Intern Med | volume = 260 | issue = 5 | pages = 429-34 | month = Nov | year = 2006 | doi = 10.1111/j.1365-2796.2006.01704.x | PMID = 17040248 }}</ref> <ref name="Prasse-2009">{{Cite journal | last1 = Prasse | first1 = A. | last2 = Probst | first2 = C. | last3 = Bargagli | first3 = E.| last4 = Zissel | first4 = G. | last5 = Toews | first5 = GB. | last6 = Flaherty | first6 = KR. | last7 = Olschewski | first7 = M. | last8 = Rottoli |first8 = P. | last9 = Müller-Quernheim | first9 = J. | title = Serum CC-chemokine ligand 18 concentration predicts outcome in idiopathic pulmonary fibrosis. | journal = Am J Respir Crit Care Med | volume = 179 | issue = 8 | pages = 717-23 | month = Apr | year = 2009 | doi = 10.1164/rccm.200808-1201OC | PMID = 19179488 }}</ref> <ref name="Ishii-2003">{{Cite journal | last1 = Ishii | first1 = H. | last2 = Mukae | first2 = H. | last3 = Kadota | first3 = J. | last4 = Kaida | first4 = H. | last5 = Nagata | first5 = T. | last6 = Abe | first6 = K. | last7 = Matsukura | first7 = S. | last8 = Kohno | first8 = S. | title = High serum concentrations of surfactant protein A in usual interstitial pneumonia compared with non-specific interstitial pneumonia. | journal = Thorax | volume = 58 | issue = 1 | pages = 52-7 | month = Jan | year = 2003 | doi = | PMID = 12511721 }}</ref> | |||
==References== | ==References== |
Revision as of 17:25, 15 November 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2]
Natural history and Complications
Biomarkers
The functional lung capacity, pulmonary functions and mortality have been linked to some biomarkers. This Table summarizes the findings of different research studies.
[1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] [15].
Rapidly deteriorating lung function and higher mortality have been associated with high serum level of epithelial or macrophage-related proteins such as SP-A, SP-D, KL-6 (Krebs von den Lungen-6), CCL18 (chemokine ligand-18), and MMP-7 (matrix metalloproteinase-7) [4] [16] [17]
References
- ↑ Takahashi, H.; Fujishima, T.; Koba, H.; Murakami, S.; Kurokawa, K.; Shibuya, Y.; Shiratori, M.; Kuroki, Y.; Abe, S. (2000). "Serum surfactant proteins A and D as prognostic factors in idiopathic pulmonary fibrosis and their relationship to disease extent". Am J Respir Crit Care Med. 162 (3 Pt 1): 1109–14. doi:10.1164/ajrccm.162.3.9910080. PMID 10988138. Unknown parameter
|month=
ignored (help) - ↑ Greene, KE.; King, TE.; Kuroki, Y.; Bucher-Bartelson, B.; Hunninghake, GW.; Newman, LS.; Nagae, H.; Mason, RJ. (2002). "Serum surfactant proteins-A and -D as biomarkers in idiopathic pulmonary fibrosis". Eur Respir J. 19 (3): 439–46. PMID 11936520. Unknown parameter
|month=
ignored (help) - ↑ Yokoyama, A.; Kondo, K.; Nakajima, M.; Matsushima, T.; Takahashi, T.; Nishimura, M.; Bando, M.; Sugiyama, Y.; Totani, Y. (2006). "Prognostic value of circulating KL-6 in idiopathic pulmonary fibrosis". Respirology. 11 (2): 164–8. doi:10.1111/j.1440-1843.2006.00834.x. PMID 16548901. Unknown parameter
|month=
ignored (help) - ↑ 4.0 4.1 Satoh, H.; Kurishima, K.; Ishikawa, H.; Ohtsuka, M. (2006). "Increased levels of KL-6 and subsequent mortality in patients with interstitial lung diseases". J Intern Med. 260 (5): 429–34. doi:10.1111/j.1365-2796.2006.01704.x. PMID 17040248. Unknown parameter
|month=
ignored (help) - ↑ Takahashi, H.; Shiratori, M.; Kanai, A.; Chiba, H.; Kuroki, Y.; Abe, S. (2006). "Monitoring markers of disease activity for interstitial lung diseases with serum surfactant proteins A and D.". Respirology. 11 Suppl: S51–4. doi:10.1111/j.1440-1843.2006.00809.x. PMID 16423272. Unknown parameter
|month=
ignored (help) - ↑ Daniil, ZD.; Papageorgiou, E.; Koutsokera, A.; Kostikas, K.; Kiropoulos, T.; Papaioannou, AI.; Gourgoulianis, KI. (2008). "Serum levels of oxidative stress as a marker of disease severity in idiopathic pulmonary fibrosis". Pulm Pharmacol Ther. 21 (1): 26–31. doi:10.1016/j.pupt.2006.10.005. PMID 17161968.
- ↑ Rosas, IO.; Richards, TJ.; Konishi, K.; Zhang, Y.; Gibson, K.; Lokshin, AE.; Lindell, KO.; Cisneros, J.; Macdonald, SD. (2008). "MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis". PLoS Med. 5 (4): e93. doi:10.1371/journal.pmed.0050093. PMID 18447576. Unknown parameter
|month=
ignored (help) - ↑ Kinder, BW.; Brown, KK.; McCormack, FX.; Ix, JH.; Kervitsky, A.; Schwarz, MI.; King, TE. (2009). "Serum surfactant protein-A is a strong predictor of early mortality in idiopathic pulmonary fibrosis". Chest. 135 (6): 1557–63. doi:10.1378/chest.08-2209. PMID 19255294. Unknown parameter
|month=
ignored (help) - ↑ Barlo, NP.; van Moorsel, CH.; Ruven, HJ.; Zanen, P.; van den Bosch, JM.; Grutters, JC. (2009). "Surfactant protein-D predicts survival in patients with idiopathic pulmonary fibrosis". Sarcoidosis Vasc Diffuse Lung Dis. 26 (2): 155–61. PMID 20560296. Unknown parameter
|month=
ignored (help) - ↑ Prasse, A.; Pechkovsky, DV.; Toews, GB.; Schäfer, M.; Eggeling, S.; Ludwig, C.; Germann, M.; Kollert, F.; Zissel, G. (2007). "CCL18 as an indicator of pulmonary fibrotic activity in idiopathic interstitial pneumonias and systemic sclerosis". Arthritis Rheum. 56 (5): 1685–93. doi:10.1002/art.22559. PMID 17469163. Unknown parameter
|month=
ignored (help) - ↑ Gilani, SR.; Vuga, LJ.; Lindell, KO.; Gibson, KF.; Xue, J.; Kaminski, N.; Valentine, VG.; Lindsay, EK.; George, MP. (2010). "CD28 down-regulation on circulating CD4 T-cells is associated with poor prognoses of patients with idiopathic pulmonary fibrosis". PLoS One. 5 (1): e8959. doi:10.1371/journal.pone.0008959. PMID 20126467.
- ↑ Richards, TJ.; Kaminski, N.; Baribaud, F.; Flavin, S.; Brodmerkel, C.; Horowitz, D.; Li, K.; Choi, J.; Vuga, LJ. (2012). "Peripheral blood proteins predict mortality in idiopathic pulmonary fibrosis". Am J Respir Crit Care Med. 185 (1): 67–76. doi:10.1164/rccm.201101-0058OC. PMID 22016448. Unknown parameter
|month=
ignored (help) - ↑ McKeown, S.; Richter, AG.; O'Kane, C.; McAuley, DF.; Thickett, DR. (2009). "MMP expression and abnormal lung permeability are important determinants of outcome in IPF". Eur Respir J. 33 (1): 77–84. doi:10.1183/09031936.00060708. PMID 18829682. Unknown parameter
|month=
ignored (help) - ↑ Shinoda, H.; Tasaka, S.; Fujishima, S.; Yamasawa, W.; Miyamoto, K.; Nakano, Y.; Kamata, H.; Hasegawa, N.; Ishizaka, A. (2009). "Elevated CC chemokine level in bronchoalveolar lavage fluid is predictive of a poor outcome of idiopathic pulmonary fibrosis". Respiration. 78 (3): 285–92. doi:10.1159/000207617. PMID 19270434.
- ↑ Richter, AG.; McKeown, S.; Rathinam, S.; Harper, L.; Rajesh, P.; McAuley, DF.; Heljasvaara, R.; Thickett, DR. (2009). "Soluble endostatin is a novel inhibitor of epithelial repair in idiopathic pulmonary fibrosis". Thorax. 64 (2): 156–61. doi:10.1136/thx.2008.102814. PMID 18852160. Unknown parameter
|month=
ignored (help) - ↑ Prasse, A.; Probst, C.; Bargagli, E.; Zissel, G.; Toews, GB.; Flaherty, KR.; Olschewski, M.; Rottoli, P.; Müller-Quernheim, J. (2009). "Serum CC-chemokine ligand 18 concentration predicts outcome in idiopathic pulmonary fibrosis". Am J Respir Crit Care Med. 179 (8): 717–23. doi:10.1164/rccm.200808-1201OC. PMID 19179488. Unknown parameter
|month=
ignored (help) - ↑ Ishii, H.; Mukae, H.; Kadota, J.; Kaida, H.; Nagata, T.; Abe, K.; Matsukura, S.; Kohno, S. (2003). "High serum concentrations of surfactant protein A in usual interstitial pneumonia compared with non-specific interstitial pneumonia". Thorax. 58 (1): 52–7. PMID 12511721. Unknown parameter
|month=
ignored (help)