Focal segmental glomerulosclerosis history and symptoms: Difference between revisions
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==Clinical Presentation== | ==Clinical Presentation== | ||
Generally, primary (idiopathic) focal segmental glomerulosclerosis (FSGS) starts abruptly whereas secondary FSGS has a more insidious onset. The hallmark of FSGS is nephrotic-range proteinuria, appearing in approximately 70% of patients.<ref name="pmid7702047">{{cite journal| author=Rydel JJ, Korbet SM, Borok RZ, Schwartz MM| title=Focal segmental glomerular sclerosis in adults: presentation, course, and response to treatment. | journal=Am J Kidney Dis | year= 1995 | volume= 25 | issue= 4 | pages= 534-42 | pmid=7702047 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7702047 }} </ref><ref name="pmid15284302">{{cite journal| author=Chun MJ, Korbet SM, Schwartz MM, Lewis EJ| title=Focal segmental glomerulosclerosis in nephrotic adults: presentation, prognosis, and response to therapy of the histologic variants. | journal=J Am Soc Nephrol | year= 2004 | volume= 15 | issue= 8 | pages= 2169-77 | pmid=15284302 | doi=10.1097/01.ASN.0000135051.62500.97 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15284302 }} </ref> | Generally, primary (idiopathic) focal segmental glomerulosclerosis (FSGS) starts abruptly whereas secondary FSGS has a more insidious onset. The hallmark of FSGS is nephrotic-range proteinuria, appearing in approximately 70% of patients.<ref name="pmid7702047">{{cite journal| author=Rydel JJ, Korbet SM, Borok RZ, Schwartz MM| title=Focal segmental glomerular sclerosis in adults: presentation, course, and response to treatment. | journal=Am J Kidney Dis | year= 1995 | volume= 25 | issue= 4 | pages= 534-42 | pmid=7702047 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7702047 }} </ref><ref name="pmid15284302">{{cite journal| author=Chun MJ, Korbet SM, Schwartz MM, Lewis EJ| title=Focal segmental glomerulosclerosis in nephrotic adults: presentation, prognosis, and response to therapy of the histologic variants. | journal=J Am Soc Nephrol | year= 2004 | volume= 15 | issue= 8 | pages= 2169-77 | pmid=15284302 | doi=10.1097/01.ASN.0000135051.62500.97 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15284302 }} </ref> | ||
Common signs and symptoms associated with FSGS are shown below<ref name="pmid7702047">{{cite journal|author=Rydel JJ, Korbet SM, Borok RZ, Schwartz MM| title=Focal segmental glomerular sclerosis in adults: presentation, course, and response to treatment. | journal=Am J Kidney Dis | year= 1995 | volume= 25 | issue= 4 | pages= 534-42 | pmid=7702047 | doi= | pmc= |url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7702047 }} </ref><ref name="pmid15284302">{{cite journal| author=Chun MJ, Korbet SM, Schwartz MM, Lewis EJ|title=Focal segmental glomerulosclerosis in nephrotic adults: presentation, prognosis, and response to therapy of the histologic variants. | journal=J Am Soc Nephrol | year= 2004 |volume= 15 | issue= 8 | pages= 2169-77 | pmid=15284302 | doi=10.1097/01.ASN.0000135051.62500.97| pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15284302 }} </ref>: | Common signs and symptoms associated with FSGS are shown below<ref name="pmid7702047">{{cite journal|author=Rydel JJ, Korbet SM, Borok RZ, Schwartz MM| title=Focal segmental glomerular sclerosis in adults: presentation, course, and response to treatment. | journal=Am J Kidney Dis | year= 1995 | volume= 25 | issue= 4 | pages= 534-42 | pmid=7702047 | doi= | pmc= |url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7702047 }} </ref><ref name="pmid15284302">{{cite journal| author=Chun MJ, Korbet SM, Schwartz MM, Lewis EJ|title=Focal segmental glomerulosclerosis in nephrotic adults: presentation, prognosis, and response to therapy of the histologic variants. | journal=J Am Soc Nephrol | year= 2004 |volume= 15 | issue= 8 | pages= 2169-77 | pmid=15284302 | doi=10.1097/01.ASN.0000135051.62500.97| pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15284302 }} </ref>: | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Clinical Presentation
Generally, primary (idiopathic) focal segmental glomerulosclerosis (FSGS) starts abruptly whereas secondary FSGS has a more insidious onset. The hallmark of FSGS is nephrotic-range proteinuria, appearing in approximately 70% of patients.[1][2]
Common signs and symptoms associated with FSGS are shown below[1][2]:
- Frothy/foamy urine suggestive of proteinuria
- Red discoloration of urine suggestive of hematuria may be present
- High blood pressure
- Signs of fluid overload, such as peripheral edema, periorbital edema, or ascites
- Fatigue and malaise
- Other signs of renal insufficiency
Additionally, a positive family history, heroin abuse, chronic viral infections, and use of associated medications must be ruled out during history-taking.
References
- ↑ 1.0 1.1 Rydel JJ, Korbet SM, Borok RZ, Schwartz MM (1995). "Focal segmental glomerular sclerosis in adults: presentation, course, and response to treatment". Am J Kidney Dis. 25 (4): 534–42. PMID 7702047.
- ↑ 2.0 2.1 Chun MJ, Korbet SM, Schwartz MM, Lewis EJ (2004). "Focal segmental glomerulosclerosis in nephrotic adults: presentation, prognosis, and response to therapy of the histologic variants". J Am Soc Nephrol. 15 (8): 2169–77. doi:10.1097/01.ASN.0000135051.62500.97. PMID 15284302.