Focal segmental glomerulosclerosis history and symptoms: Difference between revisions
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*Frothy/foamy urine suggestive of proteinuria | *Frothy/foamy urine suggestive of proteinuria | ||
*Red discoloration of urine suggestive of hematuria may be present | *Red discoloration of urine suggestive of hematuria may be present | ||
* | *Headache and blurry vision, suggestive of high blood pressure | ||
*Signs of fluid overload, such as peripheral edema | *Signs of fluid overload, such as peripheral edema or periorbital edema | ||
*Dyspnea suggestive of pleural or pericardial effusion | |||
*Abdominal fullness suggestive of ascites | |||
*Fatigue and malaise | *Fatigue and malaise | ||
*Other signs of renal insufficiency | *Other signs of renal insufficiency | ||
Revision as of 23:23, 3 December 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Clinical Presentation
Generally, primary (idiopathic) focal segmental glomerulosclerosis (FSGS) starts abruptly whereas secondary FSGS has a more insidious onset. The hallmark of FSGS is nephrotic-range proteinuria, appearing in approximately 70% of patients.[1][2]
Common signs and symptoms associated with FSGS are shown below[1][2]:
- Frothy/foamy urine suggestive of proteinuria
- Red discoloration of urine suggestive of hematuria may be present
- Headache and blurry vision, suggestive of high blood pressure
- Signs of fluid overload, such as peripheral edema or periorbital edema
- Dyspnea suggestive of pleural or pericardial effusion
- Abdominal fullness suggestive of ascites
- Fatigue and malaise
- Other signs of renal insufficiency
Additionally, a positive family history, heroin abuse, chronic viral infections, and use of associated medications must be ruled out during history-taking.
References
- ↑ 1.0 1.1 Rydel JJ, Korbet SM, Borok RZ, Schwartz MM (1995). "Focal segmental glomerular sclerosis in adults: presentation, course, and response to treatment". Am J Kidney Dis. 25 (4): 534–42. PMID 7702047.
- ↑ 2.0 2.1 Chun MJ, Korbet SM, Schwartz MM, Lewis EJ (2004). "Focal segmental glomerulosclerosis in nephrotic adults: presentation, prognosis, and response to therapy of the histologic variants". J Am Soc Nephrol. 15 (8): 2169–77. doi:10.1097/01.ASN.0000135051.62500.97. PMID 15284302.