Focal segmental glomerulosclerosis laboratory findings: Difference between revisions
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Initial lab-work up should be directed first towards finding a possible etiology for FSGS. HIV testing in patients with new-onset FSGS, especially those with collapsing variant, is a must in all patient. Additionally, monitoring of disease progression by serum creatinine and proteinuria is equally important. | Initial lab-work up should be directed first towards finding a possible etiology for FSGS. HIV testing in patients with new-onset FSGS, especially those with collapsing variant, is a must in all patient. Additionally, monitoring of disease progression by serum creatinine and proteinuria is equally important. | ||
== | ==Work-Up== | ||
===Blood Work-Up=== | ===Blood Work-Up=== | ||
A comprehensive lab work-up is necessary for all patients with FSGS. Common causes of secondary FSGS, such as HIV, HBV, HCV, and systemic lupus erythematosus (SLE), should also be ruled out: | A comprehensive lab work-up is necessary for all patients with FSGS. Common causes of secondary FSGS, such as HIV, HBV, HCV, and systemic lupus erythematosus (SLE), should also be ruled out: | ||
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*Urinary protein electrophoresis | *Urinary protein electrophoresis | ||
==Laboratory Findings== | |||
===Blood=== | |||
*Anemia | *Anemia | ||
*Hypoalbuminemia | *Hypoalbuminemia | ||
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*Increased serum creatinine | *Increased serum creatinine | ||
===Urine=== | |||
*Proteinuria | *Proteinuria | ||
*No/microscopic/macroscopic hematuria | *No/microscopic/macroscopic hematuria | ||
*Dysmorphic red blood cells | *Dysmorphic red blood cells | ||
*Fatty casts | *Fatty casts | ||
==References== | ==References== | ||
Revision as of 23:42, 3 December 2013
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Focal segmental glomerulosclerosis Microchapters |
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Differentiating Focal segmental glomerulosclerosis from other Diseases |
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Risk calculators and risk factors for Focal segmental glomerulosclerosis laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Initial lab-work up should be directed first towards finding a possible etiology for FSGS. HIV testing in patients with new-onset FSGS, especially those with collapsing variant, is a must in all patient. Additionally, monitoring of disease progression by serum creatinine and proteinuria is equally important.
Work-Up
Blood Work-Up
A comprehensive lab work-up is necessary for all patients with FSGS. Common causes of secondary FSGS, such as HIV, HBV, HCV, and systemic lupus erythematosus (SLE), should also be ruled out:
- Complete blood count (CBC)
- Serum albumin
- Lipid profile
- Serum creatinine
- Blood urea nitrogen (BUN)
- CD4 count and HIV test (necessary for all patients with FSGS, especially collapsing variant)
- DNA/PCR for parvovirus B19
- CMV test
- Serum complement C3 and C4
- ANA profile
- Titers of antibodies specific for systemic diseases, such as anti-dsDNA
- c-ANCA and p-ANCA
- Serum protein electrophoresis
- Other necessary tests to rule out secondary etiologies, as suggested by history and physical exam
Urinalysis
- Urinalysis with microalbuminuria and urinary creatinine
- Urine culture
- Urinary protein electrophoresis
Laboratory Findings
Blood
- Anemia
- Hypoalbuminemia
- Abnormal lipid profile
- Increased serum creatinine
Urine
- Proteinuria
- No/microscopic/macroscopic hematuria
- Dysmorphic red blood cells
- Fatty casts