Amoxicillin-clavulanate potassium: Difference between revisions
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==Overview== | ==Overview== | ||
'''Amoxicillin/clavulanic acid''' ([[International Nonproprietary Name|INN]]) or '''co-amoxiclav''' ([[British Approved Name|BAN]]) is a combination [[antibiotic]] consisting of [[amoxicillin]] trihydrate, a [[β-lactam antibiotic]], and [[potassium clavulanate]], a β-lactamase inhibitor. This combination results in an antibiotic with an increased spectrum of action and restored efficacy against amoxicillin-resistant bacteria that produce β-lactamase. | |||
Unlike [[co-trimoxazole]], the BAN has not been widely adopted internationally. Trade names include '''Augmentin''' (by [[GlaxoSmithKline]]),<ref name="BNF">{{cite book |title=[[British National Formulary]] |edition=57 |date=March 2009}}</ref> '''Clavamox''' (by [[Pfizer]]), '''Tyclav''' (by Beximco Pharma), and many others. | |||
==Category== | ==Category== | ||
Revision as of 00:38, 6 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]
Overview
Amoxicillin/clavulanic acid (INN) or co-amoxiclav (BAN) is a combination antibiotic consisting of amoxicillin trihydrate, a β-lactam antibiotic, and potassium clavulanate, a β-lactamase inhibitor. This combination results in an antibiotic with an increased spectrum of action and restored efficacy against amoxicillin-resistant bacteria that produce β-lactamase.
Unlike co-trimoxazole, the BAN has not been widely adopted internationally. Trade names include Augmentin (by GlaxoSmithKline),[1] Clavamox (by Pfizer), Tyclav (by Beximco Pharma), and many others.
Category
US Brand Names
AUGMENTIN®
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Overdosage | Dosage and Administration | How Supplied
Mechanism of Action
Amoxicillin is a semisynthetic antibiotic with in vitro bactericidal activity against Gram-positive and Gram-negative bacteria. Amoxicillin is, however, susceptible to degradation by beta-lactamases, and therefore, the spectrum of activity does not include organisms which produce these enzymes. Clavulanic acid is a beta-lactam, structurally related to the penicillins, which possesses the ability to inactivate some beta-lactamase enzymes commonly found in microorganisms resistant to penicillins and cephalosporins. In particular, it has good activity against the clinically important plasmid-mediated beta-lactamases frequently responsible for transferred drug resistance.[2]
References
- ↑ British National Formulary (57 ed.). March 2009.
- ↑ "AUGMENTIN (AMOXICILLIN AND CLAVULANATE POTASSIUM) TABLET, FILM COATED AUGMENTIN (AMOXICILLIN AND CLAVULANATE POTASSIUM) POWDER, FOR SUSPENSION [DR. REDDY'S LABORATORIES INC]". Text " accessdate" ignored (help)