Sandbox AZ1

Infective Endocarditis Prophylaxis Regimens

Oral Surgery

The target of the infective endocarditis prophylaxis is Streptococcus viridans:

Able to take Oral Medication Preferred Regimen ▸ Adult:Amoxicillin 2 gm as a single dose 30-60 min before procedure ▸ Pediatrics:Amoxicillin 50 mg/kg as a single dose 30-60 min before procedure Unable to take Oral Medication Preferred Regimen ▸ Adult: Ampicillin 2 g IM or IV as a single dose 30-60 min before procedure ▸ Pediatrics: Ampicillin 50 mg/kg as a single dose 30-60 min before procedure Alternative Regimen ▸ Adult: Cefazolin or Ceftriaxone 1 g IM or IV as a single dose 30-60 min before procedure ▸ Pedicatrics:Cefazolin or Ceftriaxone 50 mg/kg IM or IV as a single dose 30-60 min before procedure

Age 1—4 Weeks Preferred Regimen ▸ Ampicillin 200 mg/kg/day IV q6—8h AND ▸ Cefotaxime 150—200 mg/kg/day IV q6—8h Alternative Regimen ▸ Ampicillin 200 mg/kg/day IV q6—8h AND ▸ Gentamicin 2.5 mg/kg IV q8h OR ▸Tobramycin 2.5 mg/kg IV q8h OR ▸ Amikacin 10 mg/kg IV q8h

Age 1—23 Months Preferred Regimen ▸ Ampicillin 200 mg/kg/day IV q6—8h AND ▸ Cefotaxime 150—200 mg/kg/day IV q6—8h Alternative Regimen ▸ Ampicillin 200 mg/kg/day IV q6—8h AND ▸ Gentamicin 2.5 mg/kg IV q8h OR ▸Tobramycin 2.5 mg/kg IV q8h OR ▸ Amikacin 10 mg/kg IV q8h References