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__NOTOC__
{{Trandolapril}}
{{CMG}}; {{AE}} {{AM}}
'''''For patient information about Trandolapril, click [[Trandolapril (patient information)|here]].'''''
{{SB}} MAVIK<sup>®</sup>
==Overview==
'''Trandolapril''' is an [[ACE inhibitor]] used to treat high blood pressure, it may also be used to treat other conditions. 
It is marketed by [[Abbott Laboratories]] with the brand name Mavik&reg;.
==Category==
Antihypertensive Agents, ACE Inhibitors
==FDA Package Insert==
====MAVIK (Trandolapril hydrochloride) tablet====
'''  [[Trandolapril indications and usage|Indications and Usage]]'''
'''| [[Trandolapril dosage and administration|Dosage and Administration]]'''
'''| [[Trandolapril contraindications|Contraindications]]'''
'''| [[Trandolapril warnings and precautions|Warnings and Precautions]]'''
'''| [[Trandolapril adverse reactions|Adverse Reactions]]'''
'''| [[Trandolapril drug interactions|Drug Interactions]]'''
'''| [[Trandolapril overdosage|Overdosage]]'''
'''| [[Trandolapril description|Description]]'''
'''| [[Trandolapril clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Trandolapril clinical studies|Clinical Studies]]'''
'''| [[Trandolapril how supplied storage and handling|How Supplied/Storage and Handling]]'''
'''| [[Trandolapril patient counseling information|Patient Counseling Information]]'''
'''| [[Trandolapril labels and packages|Labels and Packages]]'''
{|
| [[File:ddd.png|800px|thumb]]
|}
==Interactions with Alcohol==
[[Category:Cardiovascular Drugs]]
[[Category:Drugs]]
{{drugbox
{{drugbox
| IUPAC_name = (2''S'',3''aR'',7''aS'')-1-[(2''S'')-2-<nowiki>[[</nowiki>(1''S'')-1-ethoxycarbonyl-3-phenyl-<br>propyl]amino]propanoyl]-2,3,3''a'',4,5,6,7,7''a''-octahydroindole-<br>2-carboxylic acid
| IUPAC_name = (2''S'',3''aR'',7''aS'')-1-[(2''S'')-2-<nowiki>[[</nowiki>(1''S'')-1-ethoxycarbonyl-3-phenyl-<br>propyl]amino]propanoyl]-2,3,3''a'',4,5,6,7,7''a''-octahydroindole-<br>2-carboxylic acid
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| routes_of_administration = Oral
| routes_of_administration = Oral
}}
}}
__NOTOC__
{{CMG}}
==[[Trandolapril (patient information)|For patient information, click here]]==
==Overview==
'''Trandolapril''' is an [[ACE inhibitor]] used to treat high blood pressure, it may also be used to treat other conditions. 
It is marketed by [[Abbott Laboratories]] with the brand name Mavik&reg;.
== Pharmacology ==
Trandolapril is a [[prodrug]] that is deesterified to trandolaprilat.  It is believed to exert its antihypertenive effect through the renin-angiotensin-aldosterone system.  Trandolapril has a half life of about 6 hours, and trandolaprilat has a half life of about 10.  Trandolaprilat has about 8 times the activity of its parent drug.  Approximately 1/3 of Trandolapril and its metabolites are excreted in the urine, and about 2/3 of Trandolapril and its metabolites are excreted in the feces.  Serum protein binding of trandolapril is about 80%.
== Mode of action ==
Trandolapril acts by competitive inhibition of [[Angiotensin Converting Enzyme]] (ACE), a key enzyme in the [[renin-angiotensin system]] (RAS pathway) which plays an important role in regulating blood pressure.  See [[ACE inhibitor]]s for more information.
== Side effects ==
Side effects reported for Trandolapril include [[nausea]], [[vomiting]], or [[diarrhea]]; [[headache]]; dry cough; [[dizziness]] or [[lightheadedness]] when sitting up or standing; [[hypotension]] or [[fatigue (physical)|fatigue]].
== Possible Drug Interactions ==
Patients also on [[diuretic]]s may experience an excessive reduction of blood pressure after initiation of therapy with Trandolapril. Trandolapril can reduce [[potassium]] loss caused by [[thiazide diuretic]]s, and increase serum [[potassium]] when used alone. Therefore [[hyperkalemia]] is a possible risk. Increased serum [[lithium]] levels can occur in patients who are also on [[lithium]]. For more information see [[ACE inhibitor|angiotensin converting enzyme (ACE) inhibitor]]s.
== Contraindications and Precautions ==
See [[ACE inhibitor]]s for more information.
== Pregnancy and Lactation==
==== '''Category D''' ====
Trandolapril is [[teratogenic]] and can cause [[birth defect]]s and even death of the developing fetus.
The highest risk to the fetus is during the second and third trimester. When pregnancy is detected, Trandolapril should be discontinued as soon as possible.
Trandolapril should not be administed to nursing mothers.
:{{main|ACE inhibitor}}
== External links ==
* [http://www.rxabbott.com/pdf/mavik.pdf Mavik] (PDF from manufacturer's website)
* [http://www.rxabbott.com/pdf/tarka.pdf Tarka] (PDF from manufacturer's website)
* [http://www.meds-help.com/trandolapril/ Trandolapril] (patient information)
* [http://www.rxlist.com/cgi/generic3/mavik.htm Trandolapril Information - rxlist.com] (Rxlist.com, The Internet Drug Index)
== References ==
* [http://www.rxlist.com/cgi/generic3/mavik.htm Trandolapril Information - rxlist.com] (Rxlist.com, The Internet Drug Index)
{{ACE inhibitors}}
[[Category:ACE inhibitors]]
[[Category:prodrugs]]
[[Category:Drugs]]
[[hr:Trandolapril]]
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}

Revision as of 20:44, 18 February 2014

Trandolapril
MAVIC® FDA Package Insert
Indications and Usage
Dosage and Administration
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Overdosage
Description
Clinical Pharmacology
Clinical Studies
How Supplied/Storage and Handling
Patient Counseling Information
Labels and Packages
Clinical Trials on Trandolapril
ClinicalTrials.gov

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amr Marawan, M.D. [2]

For patient information about Trandolapril, click here.

Synonyms / Brand Names: MAVIK®

Overview

Trandolapril is an ACE inhibitor used to treat high blood pressure, it may also be used to treat other conditions. It is marketed by Abbott Laboratories with the brand name Mavik®.

Category

Antihypertensive Agents, ACE Inhibitors

FDA Package Insert

MAVIK (Trandolapril hydrochloride) tablet

Indications and Usage | Dosage and Administration | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Overdosage | Description | Clinical Pharmacology | Clinical Studies | How Supplied/Storage and Handling | Patient Counseling Information | Labels and Packages

Interactions with Alcohol

Trandolapril
Clinical data
Pregnancy
category
  • US: D (Evidence of risk)
Routes of
administration		Oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Protein bindingTrandolapril 80%
(independent of concentration)
Trandolaprilat 65 to 94%
(concentration-dependent)
MetabolismHepatic
Elimination half-life6 hours (trandolapril)
10 hours (trandolaprilat)
ExcretionFecal and renal
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC24H34N2O5
Molar mass430.537 g/mol
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