Creutzfeldt-Jakob disease laboratory findings: Difference between revisions
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{{Creutzfeldt-Jakob disease}} | {{Creutzfeldt-Jakob disease}} | ||
{{CMG}} | |||
==Overview== | ==Overview== | ||
Routine laboratory tests are usually normal in Creutzfeldt Jakob disease. Analysis of CSF for [[14-3-3 protein]] may be helpful in the diagnosis of Creutzfeldt-Jakob disease.<ref name="Muayqil-2012">{{Cite journal | last1 = Muayqil | first1 = T. | last2 = Gronseth | first2 = G. | last3 = Camicioli | first3 = R. | title = Evidence-based guideline: diagnostic accuracy of CSF 14-3-3 protein in sporadic Creutzfeldt-Jakob disease: report of the guideline development subcommittee of the American Academy of Neurology. | journal = Neurology | volume = 79 | issue = 14 | pages = 1499-506 | month = Oct | year = 2012 | doi = 10.1212/WNL.0b013e31826d5fc3 | PMID = 22993290 }}</ref> Other elevated proteins in CSF may include S-100, neuron specific enolase, and Tau protein. | |||
==Laboratory Tests== | ==Laboratory Tests== | ||
* Routine laboratory tests are normal in Creutzfeldt Jakob disease. | * Routine laboratory tests are usually normal in Creutzfeldt Jakob disease. | ||
* | *[[Liver function tests]] may occasionally be elevated.<ref name="Tanaka-1992">{{Cite journal | last1 = Tanaka | first1 = M. | last2 = Iizuka | first2 = O. | last3 = Yuasa | first3 = T. | title = Hepatic dysfunction in Creutzfeldt-Jakob disease. | journal = Neurology | volume = 42 | issue = 6 | pages = 1249 | month = Jun | year = 1992 | doi = | PMID = 1302460 }}</ref> | ||
* In CSF, elevated concentrations of following protein markers may be remarkable in Creutzfeldt-Jakob disease:<ref name="Sanchez-Juan-2006">{{Cite journal | last1 = Sanchez-Juan | first1 = P. | last2 = Green | first2 = A. | last3 = Ladogana | first3 = A. | last4 = Cuadrado-Corrales | first4 = N. | last5 = Sáanchez-Valle | first5 = R. | last6 = Mitrováa | first6 = E. | last7 = Stoeck | first7 = K. | last8 = Sklaviadis | first8 = T. | last9 = Kulczycki | first9 = J. | title = CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease. | journal = Neurology | volume = 67 | issue = 4 | pages = 637-43 | month = Aug | year = 2006 | doi = 10.1212/01.wnl.0000230159.67128.00 | PMID = 16924018 }}</ref> | |||
:* 14-3-3 protein | |||
:* S-100 | |||
:* Neuron specific enolase | |||
:* [[Tau protein]] | |||
==References== | ==References== | ||
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[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Transmissible spongiform encephalopathies]] | [[Category:Transmissible spongiform encephalopathies]] | ||
Revision as of 20:12, 22 March 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Routine laboratory tests are usually normal in Creutzfeldt Jakob disease. Analysis of CSF for 14-3-3 protein may be helpful in the diagnosis of Creutzfeldt-Jakob disease.[1] Other elevated proteins in CSF may include S-100, neuron specific enolase, and Tau protein.
Laboratory Tests
- Routine laboratory tests are usually normal in Creutzfeldt Jakob disease.
- Liver function tests may occasionally be elevated.[2]
- In CSF, elevated concentrations of following protein markers may be remarkable in Creutzfeldt-Jakob disease:[3]
- 14-3-3 protein
- S-100
- Neuron specific enolase
- Tau protein
References
- ↑ Muayqil, T.; Gronseth, G.; Camicioli, R. (2012). "Evidence-based guideline: diagnostic accuracy of CSF 14-3-3 protein in sporadic Creutzfeldt-Jakob disease: report of the guideline development subcommittee of the American Academy of Neurology". Neurology. 79 (14): 1499–506. doi:10.1212/WNL.0b013e31826d5fc3. PMID 22993290. Unknown parameter
|month=ignored (help) - ↑ Tanaka, M.; Iizuka, O.; Yuasa, T. (1992). "Hepatic dysfunction in Creutzfeldt-Jakob disease". Neurology. 42 (6): 1249. PMID 1302460. Unknown parameter
|month=ignored (help) - ↑ Sanchez-Juan, P.; Green, A.; Ladogana, A.; Cuadrado-Corrales, N.; Sáanchez-Valle, R.; Mitrováa, E.; Stoeck, K.; Sklaviadis, T.; Kulczycki, J. (2006). "CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease". Neurology. 67 (4): 637–43. doi:10.1212/01.wnl.0000230159.67128.00. PMID 16924018. Unknown parameter
|month=ignored (help)