Chorioamnionitis laboratory findings

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Laboratory findings

Histology

• Neutrophil infiltration.
• Necrosis
• Thickening of amnion basement membrane.
• Chorionic microabscesses.
• Chrionic or umblical vasculitis with neutrophils infiltration.
• Inflammation of the matrix of the umblical cord (necrotizing funisitis).

Amniotic fluid culture

It is the standard diagnosis for the infection, but the delay in results and lack of enough data support its morbidity and mortality prognostic value for both mother and neonates has limited its benefit as a routine test.

Other Tests

Blood culture:limited or no benefit due to lack of supporting evidence and delay of results.

High vaginal swabs:as for blood culture, no proven benefit has been shown to use.

Glucose measurement of low amniotic fluid:values<5 mg/ml have predictive value for women with PPROM and infection, but lack sensitivity.

Biomarkers: like fetal fibronectin, thrombin-antithromin complex and salivary proteases have more specificity for preterm births and PPROM than chorioamnionitis.