Clostridium difficile infection historical perspective: Difference between revisions
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==Overview== | |||
*''Clostridium difficile'' was first isolated during an experiment in 1935 from health neonates. Following isolation, the bacterium was originally named ''Bacillus difficilis''. | |||
*The bacterium was named difficile because isolation process during the original experiment was difficult. | |||
*The association between ''C. difficile'' and antibiotic-associated diarrhea was first made in 1978 following among patients exposed to clindamycin. | |||
*In 2003, a resistant, hypervirulent strain of ''C. difficile'' (NAP/BI/027 strain) with increased synthesis of toxins A and B was first identified. The emergence of the new strain was attributed to fluoroquinolone administration. | |||
==Historical Perspective== | ==Historical Perspective== | ||
Revision as of 13:14, 21 April 2015
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Clostridium difficile Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Clostridium difficile infection historical perspective On the Web |
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FDA on Clostridium difficile infection historical perspective |
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Clostridium difficile infection historical perspective in the news |
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Risk calculators and risk factors for Clostridium difficile infection historical perspective |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
- Clostridium difficile was first isolated during an experiment in 1935 from health neonates. Following isolation, the bacterium was originally named Bacillus difficilis.
- The bacterium was named difficile because isolation process during the original experiment was difficult.
- The association between C. difficile and antibiotic-associated diarrhea was first made in 1978 following among patients exposed to clindamycin.
- In 2003, a resistant, hypervirulent strain of C. difficile (NAP/BI/027 strain) with increased synthesis of toxins A and B was first identified. The emergence of the new strain was attributed to fluoroquinolone administration.