Ebola classification: Difference between revisions

	Ebola Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Ebola from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Algorithm for the Evaluation of the Returned Traveler
Emergency Department Evaluation
Case Definition
History and Symptoms
Physical Examination
Laboratory Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Hospital Preparedness
Checklists
Air Medical Transport
Monitoring and Movement Following Exposure
Primary Prevention
Future or Investigational Therapies
Postmortem Care
Postmortem Care
Case Studies
Case #1
Ebola classification On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Ebola classification All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Ebola classification
CDC on Ebola classification
Ebola classification in the news
Blogs on Ebola classification
Directions to Hospitals Treating ebola
Risk calculators and risk factors for Ebola classification

Revision as of 01:41, 27 June 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Guillermo Rodriguez Nava, M.D. [2]

Ebola virus can be classified in 5 subtypes: Zaïre, Sudan, Reston, Tai (Ivory Coast) and Bundibugyo.

The table below summarizes the ebola virus strains identified until now:

Ebola Virus Strain	Place of Discovery	Date Identified
Sudan ebolavirus	Nzara and Maridi, Sudan	Between June and November 1976
Zaire ebolavirus	Yambuku, Democratic Republic of the Congo	Between August and November 1976
Reston ebolavirus	Reston, Virginia, US.	November 1989
Ivory Coast ebolavirus	Tai Forest, Ivory Coast.	November 1994
Bundibugyo ebolavirus	Bundibugyo District, Uganda	November 2007

Among the five strains, Zaïre Ebolavirus carries the highest mortality rate.
A virus of the genus Ebolavirus is a member of the species Zaire ebolavirus if:^[1]

it is found in the Democratic Republic of the Congo, Gabon, or the Republic of the Congo.
it has a genome with two or three gene overlaps (VP35/VP40, GP/VP30, VP24/L).
it has a genomic sequence that differs from the type virus by less than 30%.

A virus of the genus Ebolavirus is a member of the species Sudan ebolavirus if:^[1]

it is endemic in Sudan and/or Uganda.
it has a genome with three gene overlaps (VP35/VP40, GP/VP30, VP24/L).
it has a genomic sequence different from Ebola virus by ≥30%, but different from that of Sudan virus by <30%.

A virus of the species Reston ebolavirus is a Reston virus if:^[2]

It has the properties of Reston ebolaviruses.
If its genome diverges from that of the prototype Reston virus, Reston virus variant Pennsylvania (RESTV/Pen), by ≤10% at the nucleotide level.^[2]

↑ ^1.0 ^1.1 Kuhn, Jens H.; Becker, Stephan; Ebihara, Hideki; Geisbert, Thomas W.; Johnson, Karl M.; Kawaoka, Yoshihiro; Lipkin, W. Ian; Negredo, Ana I.; Netesov, Sergey V.; Nichol, Stuart T.; Palacios, Gustavo; Peters, Clarence J.; Tenorio, Antonio; Volchkov, Viktor E.; Jahrling, Peter B. (2010). "Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations". Archives of Virology. 155 (12): 2083–2103. doi:10.1007/s00705-010-0814-x. ISSN 0304-8608.
↑ ^2.0 ^2.1 Invalid <ref> tag; no text was provided for refs named KuhnArch

@@ Line 50: / Line 50: @@
 =====''Reston Ebolavirus''=====
+A virus of the species ''Reston ebolavirus'' is a ''Reston virus'' if:<ref name=KuhnArch/>
+*It has the properties of Reston ebolaviruses.
+*If its [[genome]] diverges from that of the prototype ''Reston [[virus]]'', Reston virus variant Pennsylvania (RESTV/Pen), by ≤10% at the [[nucleotide]] level.<ref name=KuhnArch/>
 =====''Tai (Ivory Coast) Ebolavirus''=====