Anisindione: Difference between revisions

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{{DrugProjectFormSinglePage
{{Drugbox
|genericName=generic name
| verifiedrevid = 457131161
|aOrAn=a
| IUPAC_name = 2-(4-methoxyphenyl)indene-1,3-dione
|drugClass=Adrenergic receptor agonist
| image = Anisindione skeletal.svg
|indication=a list of indications, separated by commas.
|hasBlackBoxWarning=Yes
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|contraindications=* Condition 1
* Condition 2
* Condition 3
* Condition 4
* Condition 5
|warnings======Conidition 1=====
 
(Description)
 
|clinicalTrials=======Central Nervous System======
 
: (list/description of adverse reactions)
 
======Cardiovascular======
 
: (list/description of adverse reactions)
 
======Respiratory======
 
: (list/description of adverse reactions)
 
======Gastrointestinal======
 
: (list/description of adverse reactions)
 
======Hypersensitive Reactions======
 
: (list/description of adverse reactions)
 
======Miscellaneous======
 
: (list/description of adverse reactions)
 
=====Condition 2=====
 
======Central Nervous System======
 
: (list/description of adverse reactions)
 
======Cardiovascular======
 
: (list/description of adverse reactions)
 
======Respiratory======
 
: (list/description of adverse reactions)
 
======Gastrointestinal======
 
: (list/description of adverse reactions)
 
======Hypersensitive Reactions======
 
: (list/description of adverse reactions)
 
======Miscellaneous======
 
: (list/description of adverse reactions)
|postmarketing=(Description)
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(Description)
 
=====Drug 2=====
 
(Description)
 
=====Drug 3=====
 
(Description)
 
=====Drug 4=====
 
(Description)
 
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(Description)
|useInPregnancyFDA=(Description)
|useInPregnancyAUS=(Description)
|useInLaborDelivery=(Description)
|useInNursing=(Description)
|useInPed=(Description)
|useInGeri=(Description)
|useInGender=(Description)
|useInRace=(Description)
|useInRenalImpair=(Description)
|useInHepaticImpair=(Description)
|useInReproPotential=(Description)
|useInImmunocomp=(Description)
|othersTitle=Others
|useInOthers=(Description)
 
|administration=(Oral/Intravenous/etc)
|monitoring======Condition 1=====
 
(Description regarding monitoring, from ''Warnings'' section)
 
=====Condition 2=====
 
(Description regarding monitoring, from ''Warnings'' section)
 
=====Condition 3=====
 
(Description regarding monitoring, from ''Warnings'' section)
|IVCompat====Solution===
 
====Compatible====
 
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====Not Tested====
 
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====Variable====
 
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===Y-Site===
 
====Compatible====
 
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====Variable====
 
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====Incompatible====
 
* Solution 1
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===Admixture===
 
====Compatible====
 
* Solution 1
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* Solution 1
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====Variable====
 
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===Syringe===
 
====Compatible====
 
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* Solution 1
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* Solution 1
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===TPN/TNA===
 
====Compatible====
 
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====Not Tested====
 
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====Variable====
 
* Solution 1
* Solution 2
* Solution 3
 
====Incompatible====
 
* Solution 1
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|overdose====Acute Overdose===
 
====Signs and Symptoms====
 
(Description)
 
====Management====
 
(Description)
 
===Chronic Overdose===
 
====Signs and Symptoms====
 
(Description)
 
====Management====
 
(Description)
|drugBox={{Drugbox2
| verifiedrevid =
| IUPAC_name =
| image =  
| drug_name =


<!--Clinical data-->
<!--Clinical data-->
| tradename =  
| tradename =
| MedlinePlus =  
| Drugs.com = {{drugs.com|CONS|anisindione}}
| licence_US =  
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_AU =  
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_US =  
| pregnancy_category = 
| legal_status =  
| legal_AU = <!-- Unscheduled / S2 / S4 / S8 -->
| routes_of_administration =
| legal_UK = <!-- GSL / P / POM / CD -->
| legal_US = <!-- OTC / Rx-only -->
| legal_status =
| routes_of_administration = Oral


<!--Pharmacokinetic data-->
<!--Pharmacokinetic data-->
| bioavailability =  
| bioavailability =
| metabolism =  
| metabolism =
| elimination_half-life =
| excretion =
| excretion =  


<!--Identifiers-->
<!--Identifiers-->
| CAS_number_Ref =  
| CASNo_Ref = {{cascite|correct|CAS}}
| CAS_number =  
| CAS_number_Ref = {{cascite|correct|??}}
| ATC_prefix =  
| CAS_number = 117-37-3
| ATC_suffix =  
| ATC_prefix = none
| PubChem =  
| ATC_supplemental =
| IUPHAR_ligand =  
| PubChem = 2197
| DrugBank_Ref =
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =  
| DrugBank = DB01125
| ChemSpiderID_Ref =  
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID =  
| ChemSpiderID = 2112
| UNII_Ref =  
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII =  
| UNII = S747T1ERAJ
| KEGG_Ref =  
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG =  
| KEGG = D07457
| ChEBI_Ref =  
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI =  
| ChEBI = 133809
| ChEMBL_Ref =  
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL =  
| ChEMBL = 712


<!--Chemical data-->
<!--Chemical data-->
| C= | H= | N= | O=  
| C=16 | H=12 | O=3
| molecular_weight =  
| molecular_weight = 252.265 g/mol
| smiles =  
| smiles = O=C2c1ccccc1C(=O)C2c3ccc(OC)cc3
| InChI =  
| InChI = 1/C16H12O3/c1-19-11-8-6-10(7-9-11)14-15(17)12-4-2-3-5-13(12)16(14)18/h2-9,14H,1H3
| InChIKey =  
| InChIKey = XRCFXMGQEVUZFC-UHFFFAOYAE
| StdInChI_Ref =  
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI =  
| StdInChI = 1S/C16H12O3/c1-19-11-8-6-10(7-9-11)14-15(17)12-4-2-3-5-13(12)16(14)18/h2-9,14H,1H3
| StdInChIKey_Ref =  
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey =  
| StdInChIKey = XRCFXMGQEVUZFC-UHFFFAOYSA-N
| melting_point =
}}
}}
|mechAction=(Description)
__NOTOC__
|structure=(Description with picture)
{{SI}}
|PD=(Description)
{{CMG}}
|PK=(Description)
|nonClinToxic=(Description)
|clinicalStudies======Condition 1=====
 
(Description)


=====Condition 2=====
==Overview==


(Description)
'''Anisindione''' (brand name '''Miradon''') is a synthetic [[anticoagulant]] and an [[indanedione]] derivative. It prevents the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver by inhibiting the vitamin K–mediated gamma-carboxylation of precursor proteins.


=====Condition 3=====
{{Antithrombotics}}


(Description)
[[Category:Cardiovascular Drugs]]
|howSupplied=(Description)
[[Category:Anticoagulants]]
|fdaPatientInfo=(Patient Counseling Information)
|nlmPatientInfo=(Link to patient information page)
|lookAlike=* (Paired Confused Name 1a) — (Paired Confused Name 1b)
* (Paired Confused Name 2a) — (Paired Confused Name 2b)
* (Paired Confused Name 3a) — (Paired Confused Name 3b)
|drugShortage=Drug Shortage
}}

Latest revision as of 22:24, 27 June 2014

Anisindione
File:Anisindione skeletal.svg
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration		Oral
ATC code
  • none
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC16H12O3
Molar mass252.265 g/mol
3D model (JSmol)
  (verify)

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Anisindione (brand name Miradon) is a synthetic anticoagulant and an indanedione derivative. It prevents the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver by inhibiting the vitamin K–mediated gamma-carboxylation of precursor proteins.

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