Upper gastrointestinal bleeding causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ogheneochuko Ajari, MB.BS, MS [2]

Overview

There are many causes for upper GI hemorrhage. Causes are usually anatomically divided into their location in the upper gastrointestinal tract, which could either be esophageal (for example esophageal varices) or gastric (an example is gastric ulcer) or duodenal e.g. duodenal ulcer. Patients are also usually stratified into having either variceal or non-variceal sources of upper GI hemorrhage, as the two have different treatment algorithms and prognosis. Other causes could be from infectious diseases, medication side effects, trauma or malignancy e.t.c.

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

• Anthrax
• Ebola virus

Common Causes

• Duodenal ulcer
• Esophagitis
• Esophageal varices
• Gastric tumors
• Gastric ulcer
• Gastritis
• Mallory-Weiss syndrome
• Peptic ulcer

Causes by Organ System

Cardiovascular	Cholesterol embolism, mesenteric vascular occlusion, vasculitis
Chemical/Poisoning	Arsenic trioxide, arsenicals, caustic ingestion, ethylene glycol, mercury
Dental	No underlying causes
Dermatologic	Craniomandibular dermatodysostosis, Degos disease, dermatomyositis, hereditary haemorrhagic telangiectasia, Osler-Weber-Rendu syndrome, vasculitis
Drug Side Effect	Alendronate, alosetron, anticoagulants, aspirin, bevacizumab, clopidogrel, colchicine, dicoumarol, indomethacin, iron compounds, melarsoprol, NSAIDS, phenprocoumon, phenylbutazone, polyethylene glycol-electrolyte solution (PEG-ES), potassium chloride, quinidine, tetracycline, warfarin, zinc, ziv-aflibercept
Ear Nose Throat	Hereditary haemorrhagic telangiectasia, Osler-Weber-Rendu syndrome
Endocrine	Carcinoid
Environmental	No underlying causes
Gastroenterologic	Alcoholic cirrhosis, alcoholic fatty liver, anal fissure, angiodysplasia, aortoenteric fistula, Banti's syndrome, biliary atresia, bowel ischemia, bowel obstruction, bowel strangulation, Budd-Chiari syndrome, chronic portal vein thrombosis, coats plus syndrome, colitis, colitis cystica profunda, colonic diverticulosis, colonic tubular adenomata, colonic villous adenomata, colonoscopy, colorectal cancer, Crohn's disease, Degos disease, Dieulafoy's ulcer, duodenal polypectomy, duodenal ulcer, duodenal webs, duplication cysts, esophageal cancer, esophageal cyst, esophageal varices, esophagitis, familial adenomatous polyposis, Gardner syndrome, gastric antral vascular ectasia, Gastric cancer, gastric polyps, gastric ulcer, gastric varices, gastric volvulus, gastric webs, gastritis, gastroduodenal ulcers, gastrointestinal duplications, hemobilia, hemorrhoids, hemosuccus pancreaticus, hepatic arterioportal fistula, intussusception, liver cirrhosis, Mallory-Weiss syndrome, Mallory-Weiss tear, Meckel's diverticulum, mesenteric vascular occlusion, Ménétrier's disease, peptic ulcer, Peutz-Jeghers syndrome, pneumatosis cystoides intestinalis, portal hypertension, portal hypertensive gastropathy, proctitis, ruptured esophageal varices, solitary rectal ulcer syndrome, stomach cancer, stress gastritis, stress ulcer, superior mesenteric artery occlusion, ulcerative colitis, watermelon stomach, Zollinger-Ellison syndrome
Genetic	Banti's syndrome, carbamoylphosphate synthetase deficiency, coats plus syndrome, Crohn's disease, Ehlers-Danlos syndrome, familial adenomatous polyposis, Gardner syndrome, hepatorenal tyrosinemia, Kasabach-Merritt syndrome, neurofibromatosis type I, Peutz-Jeghers syndrome, pseudoxanthoma elasticum, Wiskott-Aldrich syndrome
Hematologic	Blood clotting disorders, carcinoid, coagulopathy, essential thrombocytosis, hemophilia, haemorrhagic disease of the newborn, hemorrhagic thrombocythemia, Henoch-Schoenlein purpura, iron deficiency anemia, Kasabach-Merritt syndrome, systemic mastocytosis, thrombocytopenia, Wiskott-Aldrich syndrome
Iatrogenic	Parenteral nutrition-induced liver disease, post-surgical anastomosis, radiation-induced telangiectasia
Infectious Disease	Acanthocephaliasis, ancylostoma duodenale, angiostrongyliasis, anthrax, bacillary dysentery, balantidiasis, candida albicans, cytomegalovirus, ebola virus, entamoeba histolytica, giardiasis, helicobacter pylori, herpes simplex virus, Katayama fever , necator americanus (hookworm), parasites, schistosoma mansoni, strongyloidiasis, trichuriasis, typhoid fever, yellow fever
Musculoskeletal/Orthopedic	Craniomandibular dermatodysostosis, Ehlers-Danlos syndrome, pelvic fracture
Neurologic	Degos disease, hereditary haemorrhagic telangiectasia, Labrune syndrome, neurofibromatosis type I, Osler-Weber-Rendu syndrome
Nutritional/Metabolic	Carbamoylphosphate synthetase deficiency, hepatorenal tyrosinemia, milk protein intolerance
Obstetric/Gynecologic	Choriocarcinoma, endometriosis, leiomyoma
Oncologic	Adenocarcinoma, anal cancer, blue rubber bleb nevus syndrome, carcinoid, cecal carcinoma, choriocarcinoma, colorectal cancer, esophageal cancer, familial adenomatous polyposis, Gardner syndrome, gastric cancer, hemangiomas, kaposi sarcoma, lipoma, lymphoma, malignancy, melanoma, mesenchymal neoplasm, metastatic tumor, Peutz-Jeghers syndrome, small bowel cancer, small bowel lymphoma, small bowel tumors, stomach cancer, systemic mastocytosis, tumors
Ophthalmologic	Coats plus syndrome
Overdose/Toxicity	Drug overdose
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal/Electrolyte	Cholesterol embolism, chronic renal failure, craniomandibular dermatodysostosis, Henoch-Schoenlein purpura
Rheumatology/Immunology/Allergy	Crohn's disease, dermatomyositis, food allergy, food protein-induced enterocolitis syndrome (FPIES), Henoch-Schoenlein purpura, microscopic polyangiitis, polyarteritis nodosa, systemic mastocytosis, vasculitis, Wiskott-Aldrich syndrome
Sexual	No underlying causes
Trauma	Trauma
Urologic	No underlying causes
Miscellaneous	Foreign body, swallowed maternal blood

Causes in Alphabetical Order

• Acanthocephaliasis
• Adenocarcinoma
• Alcoholic cirrhosis
• Alcoholic fatty liver
• Alendronate
• Alosetron
• Anal cancer
• Anal fissure
• Ancylostoma duodenale
• Angiodysplasia
• Angiostrongyliasis
• Anthrax
• Anticoagulants
• Aortoenteric fistula
• Arsenic trioxide
• Arsenicals
• Aspirin
• Bacillary dysentery
• Balantidiasis
• Banti's syndrome
• Bevacizumab
• Biliary atresia
• Blood clotting disorders
• Blue rubber bleb nevus syndrome
• Bowel ischemia
• Bowel obstruction
• Bowel strangulation
• Budd-Chiari syndrome
• Candida albicans
• Carbamoylphosphate synthetase deficiency
• Carcinoid
• Caustic ingestion
• Cecal carcinoma
• Cholesterol embolism
• Choriocarcinoma
• Chronic portal vein thrombosis
• Chronic renal failure
• Clopidogrel
• Coagulopathy
• Coats plus syndrome
• Colchicine
• Colitis
• Colitis cystica profunda
• Colonic diverticulosis
• Colonic tubular adenomata
• Colonic villous adenomata
• Colonoscopy

• Colorectal cancer
• Craniomandibular dermatodysostosis
• Crohn's disease
• Cytomegalovirus
• Degos disease
• Dermatomyositis
• Dicoumarol
• Dieulafoy's ulcer
• Drug overdose
• Duodenal polypectomy
• Duodenal ulcer
• Duodenal webs
• Duplication cysts
• Ebola virus
• Ehlers-Danlos syndrome
• Endometriosis
• Entamoeba histolytica
• Esophageal cancer
• Esophageal cyst
• Esophageal varices
• Esophagitis
• Essential thrombocytosis
• Ethylene glycol
• Familial adenomatous polyposis
• Food allergy
• Food protein-induced enterocolitis syndrome (FPIES)
• Foreign body
• Gardner syndrome
• Gastric antral vascular ectasia
• Gastric cancer
• Gastric polyps
• Gastric ulcer
• Gastric varices
• Gastric volvulus
• Gastric webs
• Gastritis
• Gastroduodenal ulcers
• Gastrointestinal duplications
• Giardiasis
• Haemorrhoids
• Helicobacter pylori
• Hemangiomas
• Hemobilia
• Hemophilia
• Haemorrhagic disease of the newborn
• Hemorrhagic thrombocythemia

• Hemosuccus pancreaticus
• Henoch-Schoenlein purpura
• Hepatic arterioportal fistula
• Hepatorenal tyrosinemia
• Hereditary haemorrhagic telangiectasia
• Herpes simplex virus
• Indomethacin
• Intussusception
• Iron compounds
• Iron deficiency anemia
• Kaposi sarcoma
• Kasabach-Merritt syndrome
• Katayama fever
• Labrune syndrome
• Leiomyoma
• Lipoma
• Liver cirrhosis
• Lymphoma
• Malignancy
• Mallory-Weiss syndrome
• Mallory-Weiss tear
• Meckel's diverticulum
• Melanoma
• Melarsoprol
• Ménétrier's disease
• Mercury
• Mesenchymal neoplasm
• Mesenteric vascular occlusion
• Metastatic tumor
• Microscopic polyangiitis
• Milk protein intolerance
• Necator americanus (hookworm)
• Neurofibromatosis type I
• NSAIDS
• Osler-Weber-Rendu syndrome
• Parenteral nutrition-induced liver disease
• Pelvic fracture
• Peptic ulcer
• Peutz-Jeghers syndrome
• Phenprocoumon
• Phenylbutazone
• Pneumatosis cystoides intestinalis
• Polyarteritis nodosa
• Portal hypertension
• Portal hypertensive gastropathy
• Post-surgical anastomosis
• Potassium chloride

• Proctitis
• Pseudoxanthoma elasticum
• Quinidine
• Radiation-induced telangiectasia
• Ruptured esophageal varices
• Schistosoma mansoni
• Small bowel cancer
• Small bowel lymphoma
• Small bowel tumors
• Solitary rectal ulcer syndrome
• Stomach cancer
• Stress gastritis
• Stress ulcer
• Strongyloidiasis
• Superior mesenteric artery occlusion
• Swallowed maternal blood
• Systemic mastocytosis
• Tetracycline
• Thrombocytopenia
• Trauma
• Trichuriasis
• Tumors
• Typhoid fever
• Ulcerative colitis
• Vasculitis
• Warfarin
• Watermelon stomach
• Wiskott-Aldrich syndrome
• Yellow fever
• Zinc
• Ziv-aflibercept
• Zollinger-Ellison syndrome