Group B streptococcal infection laboratory tests: Difference between revisions
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Shown below is a tables that summarizes the laboratory tests that are recommended in different scenarios of possible GBS infection. | Shown below is a tables that summarizes the laboratory tests that are recommended in different scenarios of possible GBS infection. | ||
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|'''Scenario''' || '''Recommended Diagnostic Evaluation''' | | style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF" align=center |'''Scenario''' || style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF" align=center |'''Recommended Diagnostic Evaluation''' | ||
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|Infants with signs of sepsis || Complete diagnostic evaluation <br> | |style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |Infants with signs of sepsis || style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |Complete diagnostic evaluation <br> | ||
* [[CBC]] including [[white blood cell]] differential and [[platelet count]] | * [[CBC]] including [[white blood cell]] differential and [[platelet count]] | ||
* [[Blood culture]] (Blood cultures can be sterile in as many as 15%--33% of newborns with meningitis) | * [[Blood culture]] (Blood cultures can be sterile in as many as 15%--33% of newborns with meningitis) | ||
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* Culture of the [[cerebrospinal fluid]] (CSF) | * Culture of the [[cerebrospinal fluid]] (CSF) | ||
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| Infants born to women with chorioamnionitis || Limited diagnostic evaluation<br> | | style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |Infants born to women with chorioamnionitis || style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |Limited diagnostic evaluation<br> | ||
* [[CBC]] including [[white blood cell]] differential and [[platelet count]] | * [[CBC]] including [[white blood cell]] differential and [[platelet count]] | ||
* [[Blood culture]] | * [[Blood culture]] | ||
|- | |- | ||
| Well-appearing infants whose mothers had no [[chorioamnionitis]] and no indication for GBS prophylaxis || No routine diagnostic testing | | style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |Well-appearing infants whose mothers had no [[chorioamnionitis]] and no indication for GBS prophylaxis || style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |No routine diagnostic testing | ||
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| Well-appearing infants of any gestational age whose mother received adequate intrapartum GBS prophylaxis || No routine diagnostic testing | | style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |Well-appearing infants of any gestational age whose mother received adequate intrapartum GBS prophylaxis || style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |No routine diagnostic testing | ||
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| Well-appearing infants born to mothers who had an indication for GBS prophylaxis but received no or inadequate prophylaxis and the infant is well-appearing and ≥37 weeks and 0 days' gestational age and the duration of membrane rupture before delivery was <18 hours|| No routine diagnostic testing | | style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |Well-appearing infants born to mothers who had an indication for GBS prophylaxis but received no or inadequate prophylaxis and the infant is well-appearing and ≥37 weeks and 0 days' gestational age and the duration of membrane rupture before delivery was <18 hours|| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |No routine diagnostic testing | ||
|- | |- | ||
| Well-appearing infant and either <37 weeks and 0 days' gestational age or the duration of membrane rupture before delivery was ≥18 hours||Limited diagnostic evaluation<br> | | style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |Well-appearing infant and either <37 weeks and 0 days' gestational age or the duration of membrane rupture before delivery was ≥18 hours||style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |Limited diagnostic evaluation<br> | ||
* [[CBC]] including [[white blood cell]] differential and [[platelet count]] | * [[CBC]] including [[white blood cell]] differential and [[platelet count]] | ||
* [[Blood culture]] | * [[Blood culture]] |
Revision as of 14:48, 20 August 2014
Group B Streptococcal Infection Microchapters |
Differentiating Group B Streptococcal Infection from other Diseases |
---|
Diagnosis |
Treatment |
Case Studies |
Group B streptococcal infection laboratory tests On the Web |
American Roentgen Ray Society Images of Group B streptococcal infection laboratory tests |
Group B streptococcal infection laboratory tests in the news |
Directions to Hospitals Treating Group B streptococcal infection |
Risk calculators and risk factors for Group B streptococcal infection laboratory tests |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]
Overview
Laboratory Tests
GBS Infection in Neonates
Infants with Signs of Sepsis
Any newborn with signs of sepsis should receive a full diagnostic evaluation and receive antibiotic therapy pending the results of the evaluation, regardless of the maternal colonization status (class A, level of evidence II).
The full diagnostic evaluation should include:
- CBC including white blood cell differential and platelet count
- Blood culture (Blood cultures can be sterile in as many as 15%--33% of newborns with meningitis)
- Chest radiograph
- Lumbar puncture
- Culture of the cerebrospinal fluid (CSF)
Infants Born to Women with Chorioamnionitis
Well-appearing newborns whose mothers had suspected chorioamnionitis should undergo a limited diagnostic evaluation and receive antibiotic therapy pending culture results (class A, level of evidence II).
The limited diagnostic evaluation should include:
- CBC including white blood cell differential and platelet count
- Blood culture
- No chest radiograph
- No lumbar puncture
Well-Appearing Infants Exposed to Inadequate Intrapartum Antibiotics
Well-appearing infants whose mothers had no chorioamnionitis and no indication for GBS prophylaxis should be managed according to routine clinical care, and no routine diagnostic testing is recommended.
Well-appearing infants of any gestational age whose mother received adequate intrapartum GBS prophylaxis (≥4 hours of penicillin, ampicillin, or cefazolin before delivery) should be observed for ≥48 hours, and no routine diagnostic testing is recommended (class B, level of evidence III).
For well-appearing infants born to mothers who had an indication for GBS prophylaxis but received no or inadequate prophylaxis, if the infant is well-appearing and ≥37 weeks and 0 days' gestational age and the duration of membrane rupture before delivery was <18 hours, then the infant should be observed for ≥48 hours, and no routine diagnostic testing is recommended (class B, level of evidence III).
If the infant is well-appearing and either <37 weeks and 0 days' gestational age or the duration of membrane rupture before delivery was ≥18 hours, then the infant should undergo a limited diagnostic evaluation and observation for ≥48 hours (class B, level of evidence III).
The limited diagnostic evaluation should include:
- CBC including white blood cell differential and platelet count
- Blood culture
- No chest radiograph
- No lumbar puncture
Shown below is a tables that summarizes the laboratory tests that are recommended in different scenarios of possible GBS infection.
Scenario | Recommended Diagnostic Evaluation |
Infants with signs of sepsis | Complete diagnostic evaluation
|
Infants born to women with chorioamnionitis | Limited diagnostic evaluation
|
Well-appearing infants whose mothers had no chorioamnionitis and no indication for GBS prophylaxis | No routine diagnostic testing |
Well-appearing infants of any gestational age whose mother received adequate intrapartum GBS prophylaxis | No routine diagnostic testing |
Well-appearing infants born to mothers who had an indication for GBS prophylaxis but received no or inadequate prophylaxis and the infant is well-appearing and ≥37 weeks and 0 days' gestational age and the duration of membrane rupture before delivery was <18 hours | No routine diagnostic testing |
Well-appearing infant and either <37 weeks and 0 days' gestational age or the duration of membrane rupture before delivery was ≥18 hours | Limited diagnostic evaluation
|