Dyspepsia causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Causes

Common Causes

• Acid reflux / heartburn

• Alcohol

• Aspirin and many other painkillers

• Duodenal ulcer

• Eating fatty foods

• Eating just before sleeping

• Eating spicy foods

• Eating too late in the evening

• Excess caffeine consumption

• Gastric ulcer

• Intestinal obstruction

• Malabsorption

• Obesity

Causes by Organ system

Cardiovascular	No underlying causes
Chemical / poisoning	4-Chlorodehydromethyltestosterone, amanita phalloides, smoking, sodium dichloroisocyanurate
Dermatologic	No underlying causes
Drug Side Effect	4-Chlorodehydromethyltestosterone, adefovir (patient information), acarbose, aspirin and many other painkillers, alendronate, atazanavir (patient information), calcium channel blockers, cholestyramine (patient information), cholestyramine resin (patient information), colofac, duloxetine, erythromycin, efavirenz (patient information), estrogen and oral contraceptives, emtricitabine (patient information), Epoetin Alfa Injection, fentanyl skin patches (patient information), frovatriptan (patient information), imatinib (patient information), interferon Beta-1b Injection (patient information), lithium (patient information), methylxanthines, metronidazole , meropenem Injection (patient information), oxycodone, orlistat, potassium supplements, pergolide (patient information), pramlintide injection (patient information), quetiapine (patient information), rivastigmine (patient information), simvastatin, steroid medications, tadalafil, tiotropium Oral Inhalation (patient information), thyroid medicines
Ear Nose Throat	No underlying causes
Endocrine	Carcinoid syndrome, diabetes mellitus, hyperparathyroidism , hyperthyroidism, primary hyperparathyroidism
Environmental	Multiple chemical sensitivity
Gastroenterologic	Achlorhydria, acid reflux / heartburn, acute viral hepatitis, adult hypertrophic pyloric stenosis, aerophagy, cholecystitis, chronic hepatitis, acute and chronic pancreatitis, cirrhosis of liver, coeliac disease, colonic cancer, crohn's disease, duodenal cancer, duodenal lymphoma, duodenal polyps, duodenal ulcer, duodenal webs, duodenitis, esophageal carcinoma, esophagitis, gallstones, gastric cancer, gastric lymphoma, gastric motility disorder, gastric ulcer, gastritis, gastroesophageal reflux disease, gastrointestinal tumors, hiatus hernia, hypertrophic gastritis, intestinal motility disorder, intestinal obstruction, irritable bowel syndrome, malabsorption, Ménétriér's disease, pancreatic cancer, peptic ulcers, small intestinal bacterial overgrowth, tropical sprue, ulcerative colitis, hepatoma, ischemic bowel disease
Genetic	No underlying causes
Hematologic	No underlying causes
Iatrogenic	No underlying causes
Infectious Disease	Amebic dysentery, fascioliasis, gastrointestinal mucormycosis, giardiasis, H. Pylori, hookworm, opisthorchiasis, strongyloidiasis, syphilis, tuberculosis
Musculoskeletal / Ortho	No underlying causes
Neurologic	Autonomic neuropathy
Nutritional / Metabolic	Diabulimia, eating fatty foods, eating just before sleeping, eating spicy foods, eating too late in the evening, excess alcohol consumption, excess caffeine consumption, garlic, indian gooseberry, overeating, suillus luteus
Obstetric/Gynecologic	No underlying causes
Oncologic	Ovarian cancer, extranodal marginal zone B-cell Lymphoma of mucosa-associated lymphoid tissue, colonic cancer, duodenal cancer, duodenal lymphoma, esophageal carcinoma, gastric cancer, gastric lymphoma, gastrointestinal tumors, pancreatic cancer
Opthalmologic	No underlying causes
Overdose / Toxicity	Niacin, vitamin C
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal / Electrolyte	Hypercalcaemia, uremia
Rheum / Immune / Allergy	Oral allergy syndrome, sarcoidosis, scleroderma
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	Couvade, gulf War syndrome, alcohol, gas, stress, tobacco, obesity, SSRI discontinuation syndrome, Trichophagia

Causes in Alphabetical Order

4-Chlorodehydromethyltestosterone acarbose Achlorhydria Acid reflux / heartburn Acute and chronic Pancreatitis Acute viral hepatitis Adefovir (patient information) Adult hypertrophic pyloric stenosis Aerophagy Alcohol alendronate Amanita phalloides Amebic dysentery Anxiety Aspirin and many other painkillers Atazanavir (patient information) Autonomic neuropathy Calcium channel blockers Carcinoid syndrome Cholecystitis Cholestyramine (patient information) Cholestyramine Resin (patient information) Chronic hepatitis Cirrhosis of liver Coeliac disease Colofac Colon cancer Couvade Crohn's disease Diabetes mellitus Diabulimia Duloxetine Duodenal cancer Duodenal lymphoma Duodenal polyps Duodenal ulcer Duodenal webs Duodenitis Eating fatty foods Eating just before sleeping Eating spicy foods Eating too late in the evening Efavirenz (patient information) Emtricitabine (patient information) Epoetin Alfa Injection (patient information) erythromycin Esophageal carcinoma Esophagitis Estrogen and Oral contraceptives Excess caffeine consumption Extranodal Marginal Zone B-cell Lymphoma of Mucosa-Associated Lymphoid Tissue Fascioliasis Fentanyl Skin Patches (patient information) Fluticasone (aerosol) Food intolerance Frovatriptan (patient information) Gallstones Garlic Gas Gastric cancer Gastric lymphoma Gastric motility disorder Gastric ulcer Gastritis Gastroesophageal reflux disease

Gastrointestinal mucormycosis Gastrointestinal tumors Giardiasis Gluten allergy Gulf War syndrome H. Pylori Hepatoma Hiatus hernia Hookworm Hypercalcaemia hyperparathyroidism Hyperthyroidism Hypertrophic gastritis Imatinib (patient information) Indian gooseberry Infliximab Interferon Beta-1b Injection (patient information) Intestinal motility disorder Intestinal obstruction Ischemic bowel disease Irritable bowel syndrome Lithium (patient information) Malabsorption Ménétriér's disease Meropenem Injection (patient information) methylxanthines metronidazole Multiple chemical sensitivity Niacin Obesity Opisthorchiasis Oral allergy syndrome orlistat Ovarian cancer Overeating Oxycodone and aspirin (patient information) Pancreatic cancer Pergolide (patient information) potassium supplements Pramlintide injection (patient information) Pregnancy Primary hyperparathyroidism Quetiapine (patient information) Rivastigmine (patient information) Sarcoidosis Scleroderma Simvastatin Small intestinal bacterial overgrowth Smoking Sodium dichloroisocyanurate SSRI discontinuation syndrome Steroids Stress Strongyloidiasis Suillus luteus Syphilis Tadalafil Tenofovir disoproxil fumarate Thyroid medicines Tiotropium Oral Inhalation (patient information) Tobacco Trichophagia Tropical sprue Tuberculosis Ulcerative colitis Uremia Vitamin C