Systemic lupus erythematosus causes: Difference between revisions
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Revision as of 15:17, 30 October 2014
Systemic lupus erythematosus Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]
Overview
Causes
Despite the dramatic rise in lupus research in recent years, the exact cause of the disease remains unknown. Indeed, consensus is still lacking on whether lupus is a single condition or a group of related diseases. SLE is a chronic inflammatory disease believed to be a type III hypersensitivity response with potential type II involvement,[1] characterized by the body's production of antibodies against the nuclear components of its own cells. There are three mechanisms by which lupus is thought to develop:
- Genetic predisposition
- Environmental triggers
- Drug reaction (drug-induced lupus) - here are about 400 medications currently in use that can cause this condition, though the most common drugs are