Miosis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Causes

Diseases

• Horner syndrome (a set of abnormalities in the nervous supply of the face due to damage to the sympathetic nervous system).
• Pancoast tumor (a tumor of the apical lung), due to damage to the ascending sympathetic tract that would normally cause the pupil to dilate.
• Hemorrhage into pons (intracranial hemorrhage)

Drugs

• Opioids such as tramadol, codeine, morphine, heroin and methadone
• Antipsychotics, including haloperidol, thorazine, olanzapine, quetiapine and others
• Cholinergic agents such as those used to treat Alzheimer's disease and nerve gases; cholinergic drugs such as carbachol (Miostat) and neostigmine
• Some cancer chemotherapy drugs, including camptothecin derivatives
• Mirtazapine, a noradrenergic and specific serotonergic antidepressant (NaSSA)
• Trazodone
• Some MAO Inhibitors.
• In some rare cases, when exposed to mustard gas.
• Acetaminophen and Oxycodone
• Pyridostigmine

Miotics

A miotic substance causes the constriction of the pupil of the eye (or miosis). It is the opposite of a Mydriatic substance, which causes dilation of the pupil.

Causes in Alphabetical Order

• Adie's pupil (long standing)
• Argyll Robertson Pupils
• Anisocoria
• Coma
• Horner's Syndrome
• Iritis
• Posterior iris synechiae
• Systemic opioids
• Systemic cholinergics
• Tertiary Syphillis
• Topical cholinergics