Purpura causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Causes

Common Causes

• Disseminated intravascular coagulation
• Thrombocytopenia
• Factor VIII deficiency
• Von Willebrand's disease
• Idiopathic thrombocytopenic purpura
• Vitamin K deficiency
• Thrombotic thrombocytopenic purpura

Causes by Organ System

Cardiovascular	Acute infantile hemorrhagic edema, Churg-Strauss syndrome, Endocarditis, Fat embolism, Henoch-Schonlein purpura, Leukocytoclastic vasculitis, Vascular hemostatic disorder, Vasculitis, Wegener's Granulomatosis , Septic emboli
Chemical / poisoning	Arsenicals, Iodides
Dermatologic	Acroangiodermatitis, Grey Turner sign
Drug Side Effect	Alemtuzumab, Aspirin, Atropine, Aztreonam, Chloral hydrate, Cilostazol, Corticosteroids, Co-trimoxazole, Dapsone, Febuxostat, Glucocorticoids, Gold, Hydralazine,* Doxycycline, Hydrochlorothiazide Ketoconazole, Ketorolac tromethamine, Meprobamate, Oxcarbazepine, Penicillin, Quinidine, Sulfasalazine, Sulfonamides, Sulindac, Tetracycline
Ear Nose Throat	No underlying causes
Endocrine	Cushing syndrome
Environmental	No underlying causes
Gastroenterologic	Liver disease, Vomiting
Genetic	Ehlers-Danlos syndrome, Ethylmalonic encephalopathy, Factor IX deficiency, Factor VIII deficiency, Hereditary haemorrhagic telangiectasia, Pseudoxanthoma elasticum, Schamberg disease, Tyrosinaemia, Von Willebrand's disease
Hematologic	Aplastic anemia, Cryoglobulinaemia, Disseminated intravascular coagulation, Hemolytic uremic syndrome, Idiopathic thrombocytopenic purpura, Leukemia, Multiple myeloma, Thrombocytopenia, Thrombotic thrombocytopenic purpura, Factor IX deficiency, Factor VIII deficiency, Von Willebrand's disease
Iatrogenic	Blood transfusion reaction
Infectious Disease	Brucellosis, Congenital cytomegalovirus, Congenital rubella, Dengue, Human monocytotropic ehrlichiosis, Leptospirosis, Measles, Meningococcemia, Neisseria gonorrhea, Neisseria meningiditis, Purpura fulminans, Q fever, Relapsing fever, Rickettsiae, Rocky mountain spotted fever, Scarlet Fever, Septic emboli, Typhoid, Typhus fever, Vibrio vulnificus, Endocarditis, Congenital cytomegalovirus, Congenital rubella
Musculoskeletal / Ortho	No underlying causes
Neurologic	No underlying causes
Nutritional / Metabolic	Scurvy, Vitamin C deficiency, Vitamin K deficiency, Tyrosinemia
Obstetric/Gynecologic	No underlying causes
Oncologic	Solid tumor invading bone marrow, Leukemia
Opthalmologic	No underlying causes
Overdose / Toxicity	Alemtuzumab, Aspirin, Atropine, Chloral hydrate, Cilostazol, Corticosteroids, Co-trimoxazole, Glucocorticoids, Gold, Hydralazine, Ketoconazole, Penicillin, Quinidine, Sulfonamides, Tetracycline
Psychiatric	Anorexia nervosa, Factitious purpura, Gardner-Diamond syndrome
Pulmonary	No underlying causes
Renal / Electrolyte	Chronic renal failure, Uremia
Rheum / Immune / Allergy	Amyloidosis, Hypersensitivity vasculitis, Lupus, Rheumatoid arthritis, Sjogren's syndrome, Leukocytoclastic vasculitis, Thrombotic thrombocytopenic purpura, Blood transfusion reaction
Sexual	No underlying causes
Trauma	Calcaneal petechiae
Urologic	No underlying causes
Dental	No underlying causes
Miscellaneous	Asphyxiation, Child abuse, Heat stroke, Senile purpura, Strangulation, Violent coughing, Amyloidosis

Causes in Alphabetical Order

Acroangiodermatitis Acute infantile hemorrhagic edema Alemtuzumab Amyloidosis Anorexia nervosa Aplastic anemia Arsenicals Asphyxiation Aspirin Atropine Aztreonam Blood transfusion reaction Brucellosis Calcaneal petechiae Child abuse Chloral hydrate Chronic renal failure Churg-Strauss syndrome Cilostazol Congenital cytomegalovirus Congenital rubella Corticosteroids Co-trimoxazole Cryoglobulinaemia Cushing syndrome Dengue Disseminated intravascular coagulation Ehlers-Danlos syndrome Endocarditis Ethylmalonic encephalopathy Factitious purpura Factor IX deficiency Factor VIII deficiency Fat embolism Gardner-Diamond syndrome Glucocorticoids Gold Grey Turner sign Heat stroke Hemolytic uremic syndrome Henoch-Schonlein purpura Hereditary haemorrhagic telangiectasia Human monocytotropic ehrlichiosis Hydralazine Hypersensitivity vasculitis Idiopathic thrombocytopenic purpura Iodides

Ketoconazole Leptospirosis Leukemia Leukocytoclastic vasculitis Liver disease Lupus Measles Meningococcemia Multiple myeloma Neisseria gonorrhea Neisseria meningiditis Penicillin Pseudoxanthoma elasticum Purpura fulminans Q fever Quinidine Relapsing fever Rheumatoid arthritis Rickettsiae Rocky mountain spotted fever Scarlet Fever Schamberg disease Scurvy Senile purpura Septic emboli Sjogren's syndrome Solid tumor invading bone marrow Strangulation Sulfonamides Tetracycline Thrombocytopenia Thrombotic thrombocytopenic purpura Typhoid Typhus fever Tyrosinaemia Uremia Vascular hemostatic disorder Vasculitis Vibrio vulnificus Violent coughing Vitamin C deficiency Vitamin K deficiency Vomiting Von Willebrand's disease Wegener's Granulomatosis