Sideroblastic anemia causes: Difference between revisions
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The common feature of these causes is a failure to completely form [[heme]] - whose biosynthesis takes place partly in the [[mitochondrion]]. This leads to deposits of iron in the [[mitochondria]] that form a ring around the [[Cell nucleus|nucleus]] of the developing [[red blood cell]]. Sometimes the disorder represents a stage in evolution of a generalized bone marrow disorder that may ultimately terminate in acute leukemia. | The common feature of these causes is a failure to completely form [[heme]] - whose biosynthesis takes place partly in the [[mitochondrion]]. This leads to deposits of iron in the [[mitochondria]] that form a ring around the [[Cell nucleus|nucleus]] of the developing [[red blood cell]]. Sometimes the disorder represents a stage in evolution of a generalized bone marrow disorder that may ultimately terminate in acute leukemia. | ||
* Toxins: [[lead]] or [[zinc]] poisoning | * Toxins: [[lead]] or [[zinc]] poisoning | ||
* Drug-induced: [[ethanol]], [[isoniazid]], [[chloramphenicol]], [[cycloserine]] | * Drug-induced: [[ethanol]], [[isoniazid]], [[chloramphenicol]], [[cycloserine]], [[Penicillamine]] | ||
* Nutritional: [[pyridoxine]] or [[copper]] deficiency | * Nutritional: [[pyridoxine]] or [[copper]] deficiency | ||
* Genetic: ALA synthase deficiency ([[X-linked]]) | * Genetic: ALA synthase deficiency ([[X-linked]]) | ||
Revision as of 17:28, 21 January 2015
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Sideroblastic anemia Microchapters |
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Sideroblastic anemia causes On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Causes
The common feature of these causes is a failure to completely form heme - whose biosynthesis takes place partly in the mitochondrion. This leads to deposits of iron in the mitochondria that form a ring around the nucleus of the developing red blood cell. Sometimes the disorder represents a stage in evolution of a generalized bone marrow disorder that may ultimately terminate in acute leukemia.
- Toxins: lead or zinc poisoning
- Drug-induced: ethanol, isoniazid, chloramphenicol, cycloserine, Penicillamine
- Nutritional: pyridoxine or copper deficiency
- Genetic: ALA synthase deficiency (X-linked)