Toxic megacolon medical therapy

Toxic Megacolon Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Fluid and electrolyte replacement help to prevent dehydration and shock. Use of corticosteroids may be indicated to suppress the inflammatory reaction in the colon if megacolon has resulted from active inflammatory bowel disease. Antibiotics may be given to prevent sepsis (a severe infection).

Contraindicated medications

Toxic Megacolon is considered an absolute contraindication to the use of the following medications:

• Alosetron
• Polyethylene glycol-electrolyte solution (PEG-ES)