Pheniramine: Difference between revisions

Jump to navigation Jump to search
Newer edit →
VisualWikitext
WikiBot (talk | contribs)
Bots, Bureaucrats, bureaucrats, interwiki, nocaptcha, Administrators
57,550 edits
m Protected "Pheniramine": Protecting pages from unwanted edits ([edit=sysop] (indefinite) [move=sysop] (indefinite))
 
Rabin Bista (talk | contribs)
nocaptcha, Administrators
4,526 edits
No edit summary
Line 1: Line 1:
{{drugbox |
{{Drugbox
| Watchedfields = changed
| verifiedrevid = 464200398
| IUPAC_name = ''N'',''N''-dimethyl-3-phenyl-3-pyridin-2-yl-propan-1-amine
| IUPAC_name = ''N'',''N''-dimethyl-3-phenyl-3-pyridin-2-yl-propan-1-amine
| image = Pheniramine.svg
| image = Pheniramine.svg
<!--Clinical data-->
| tradename =
| Drugs.com = {{drugs.com|international|pheniramine}}
| MedlinePlus = a606008
| pregnancy_AU = A
| pregnancy_US = C
| legal_status = 
| routes_of_administration = Oral ; [[Injection (medicine)|injection]] ([[intramuscular]] or slow [[Intravenous injection|intravenous]]); topical (ophthalmic/nasal solution)
<!--Pharmacokinetic data-->
| bioavailability = 
| protein_bound = 
| metabolism = [[Liver|Hepatic]] [[hydroxylation]], [[demethylation]] and [[glucuronidation]]
| elimination_half-life = 
| excretion = [[Kidney|Renal]]
<!--Identifiers-->
| CASNo_Ref = {{cascite|correct|CAS}}
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 86-21-5
| CAS_number = 86-21-5
| ATC_prefix = R06
| ATC_prefix = D04
| ATC_suffix = AB05
| ATC_suffix = AA16
| ATC_supplemental = {{ATC|R06|AB05}}
| PubChem = 4761
| PubChem = 4761
| DrugBank =  
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| C=16|H=20|N=2
| DrugBank = DB01620
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4597
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 134FM9ZZ6M
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D08355
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 1193
 
<!--Chemical data-->
| C=16 | H=20 | N=2
| molecular_weight = 240.343 g/mol
| molecular_weight = 240.343 g/mol
| bioavailability =  
| smiles = n1ccccc1C(c2ccccc2)CCN(C)C
| protein_bound =  
| InChI = 1/C16H20N2/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16/h3-10,12,15H,11,13H2,1-2H3
| metabolism = [[Liver|Hepatic]] [[hydroxylation]], [[demethylation]] and [[glucuronidation]]
| InChIKey = IJHNSHDBIRRJRN-UHFFFAOYAU
| elimination_half-life =
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| excretion = [[Kidney|Renal]]
| StdInChI = 1S/C16H20N2/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16/h3-10,12,15H,11,13H2,1-2H3
| pregnancy_AU =  <!-- A / B1 / B2 / B3 / C / D / X -->
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| pregnancy_US =  <!-- A / B            / C / D / X -->
| StdInChIKey = IJHNSHDBIRRJRN-UHFFFAOYSA-N
| pregnancy_category = 
| legal_AU =  <!-- Unscheduled / S2 / S3 / S4  / S8 -->
| legal_CA =  <!--                             / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL        / P      / POM / CD / Class A, B, C -->
| legal_US =  <!-- OTC                  / Rx-only  / Schedule I, II, III, IV, V -->
| legal_status =  
| routes_of_administration = Oral
}}
}}
'''Pheniramine maleate''' is an [[antihistamine]] used to treat [[allergy|allergic]] conditions such as [[hay fever]] or [[urticaria]]. It is generally sold in combination with other medications, rather than as a stand-alone drug. It is sold under the brand name [[Avil]] by [[Aventis]].
'''Pheniramine''' ([[International Nonproprietary Name|INN]], trade name '''Avil''', among others) is an [[antihistamine]] with [[anticholinergic]] properties used to treat [[allergy|allergic]] conditions such as [[hay fever]] or [[urticaria]]. It has relatively strong sedative effects, and may sometimes be used off-label as an over-the-counter sleeping pill in a similar manner to other sedating antihistamines such as [[diphenhydramine]]. Pheniramine is also commonly found in [[eyedrops]] used for the treatment of [[allergic conjunctivitis]].
 
Pheniramine is generally sold in combination with other medications, rather than as a stand-alone drug, although some formulations are available containing pheniramine by itself. As an example, [[Neo Citran]] contains pheniramine.
 
== Chemical relatives ==
Derivatives of pheniramine include [[chlorphenamine]], [[dexchlorpheniramine]], [[dexbrompheniramine]], [[deschlorpheniramine]], [[triprolidine]], and [[brompheniramine]]. Two other halogenated derivatives, [[iodopheniramine]] and [[fluorpheniramine]], are currently in use for research on combination therapies for malaria and some cancers. The [[halogenation]] of pheniramine increases its potency by 20-fold.
 
== Side effects ==
Pheniramine may cause drowsiness, [[bradycardia]] and over-dosage may lead to sleep disorders. Overdose may lead to [[seizures]], especially in combination with alcohol.
People combining with [[cortisol]] in the long term should avoid pheniramine as it may cause lowered levels of adrenaline (epinephrine) which may lead to loss of consciousness.
 
== See also ==
* [[Tripelennamine]]
* [[Diphenhydramine]]
* [[Doxylamine]]


{{antihistamines}}
== References ==
* [http://www.racgp.org.au/cmi/swcavilt.pdf Leaflet on Avil]{{dead link|date=April 2013}} by The [[Royal Australian College of General Practitioners]]


[[Category:Antihistamines]]
== External links ==
*{{MedlinePlusEncyclopedia|002529|Pheniramine overdose}}


{{pharma-stub}}
{{Hypnotics}}
{{Antihistamines}}
{{Cholinergics}}
{{Hallucinogens}}
{{Histaminergics}}
{{Serotonergics}}


[[th:เฟนิรามีน]]
[[Category:Amines]]
[[pl:feniramina]]
[[Category:H1 receptor antagonists]]
[[Category:Pyridines]]

Revision as of 19:50, 6 April 2015

Pheniramine
File:Pheniramine.svg
Clinical data
AHFS/Drugs.comInternational Drug Names
MedlinePlusa606008
Pregnancy
category
  • AU: A
  • US: C (Risk not ruled out)
Routes of
administration		Oral ; injection (intramuscular or slow intravenous); topical (ophthalmic/nasal solution)
ATC code
Pharmacokinetic data
MetabolismHepatic hydroxylation, demethylation and glucuronidation
ExcretionRenal
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC16H20N2
Molar mass240.343 g/mol
3D model (JSmol)
  (verify)

Pheniramine (INN, trade name Avil, among others) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It has relatively strong sedative effects, and may sometimes be used off-label as an over-the-counter sleeping pill in a similar manner to other sedating antihistamines such as diphenhydramine. Pheniramine is also commonly found in eyedrops used for the treatment of allergic conjunctivitis.

Pheniramine is generally sold in combination with other medications, rather than as a stand-alone drug, although some formulations are available containing pheniramine by itself. As an example, Neo Citran contains pheniramine.

Chemical relatives

Derivatives of pheniramine include chlorphenamine, dexchlorpheniramine, dexbrompheniramine, deschlorpheniramine, triprolidine, and brompheniramine. Two other halogenated derivatives, iodopheniramine and fluorpheniramine, are currently in use for research on combination therapies for malaria and some cancers. The halogenation of pheniramine increases its potency by 20-fold.

Side effects

Pheniramine may cause drowsiness, bradycardia and over-dosage may lead to sleep disorders. Overdose may lead to seizures, especially in combination with alcohol. People combining with cortisol in the long term should avoid pheniramine as it may cause lowered levels of adrenaline (epinephrine) which may lead to loss of consciousness.

See also

References

External links

Template:Hypnotics

Retrieved from "https://www.wikidoc.org/index.php?title=Pheniramine&oldid=1083516"