Promazine: Difference between revisions

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{{drugbox
{{Drugbox
| IUPAC_name = N,N-dimethyl-3-(10H-phenothiazin-10-yl) propan-1-amine
| verifiedrevid = 464215585
| IUPAC_name = N,N-dimethyl-3-(10H-phenothiazin-10-yl)-propan-1-amine
| image = Promazine.svg
| image = Promazine.svg
| image2= Promazine3d.png
| width = 160
| width = 160
| image2 = Promazine3d.png
<!--Clinical data-->
| tradename = 
| Drugs.com = {{drugs.com|CONS|promazine}}
| MedlinePlus = a600010
| pregnancy_category = 
| legal_status = 
| routes_of_administration = 
<!--Pharmacokinetic data-->
| bioavailability = 
| protein_bound = 94%
| metabolism = 
| elimination_half-life = 
| excretion = 
<!--Identifiers-->
| CASNo_Ref = {{cascite|correct|CAS}}
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 58-40-2
| CAS_number = 58-40-2
| ATC_prefix = N05
| ATC_prefix = N05
| ATC_suffix = AA03
| ATC_suffix = AA03
| ATC_supplemental =  
| ATC_supplemental =
| PubChem = 4926
| PubChem = 4926
| DrugBank = APRD00358
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| C=17 | H=20 | N=2 | S=1
| DrugBank = DB00420
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4757
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = O9M39HTM5W
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 8459
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 564
 
<!--Chemical data-->
| C=17 | H=20 | N=2 | S=1  
| molecular_weight = 284.42 g/mol
| molecular_weight = 284.42 g/mol
| bioavailability =  
| smiles = CN(C)CCCN1c2ccccc2Sc3c1cccc3
| protein_bound = 94%
| InChI = 1/C17H20N2S/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19/h3-6,8-11H,7,12-13H2,1-2H3
| metabolism =  
| InChIKey = ZGUGWUXLJSTTMA-UHFFFAOYAX
| elimination_half-life =  
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| excretion =
| StdInChI = 1S/C17H20N2S/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19/h3-6,8-11H,7,12-13H2,1-2H3
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| pregnancy_US = <!-- A / B / C / D / X -->
| StdInChIKey = ZGUGWUXLJSTTMA-UHFFFAOYSA-N
| pregnancy_category =
| legal_AU = <!-- Unscheduled / S2 / S4 / S8 -->
| legal_UK = <!-- GSL / P / POM / CD -->
| legal_US = <!-- OTC / Rx-only -->
| legal_status =  
| routes_of_administration =  
}}
}}


{{SI}}
'''Promazine''' ('''Sparine''') is a medication that belongs to the [[phenothiazine]] class of [[antipsychotics]]. An older medication used to treat [[schizophrenia]], it is still prescribed, alongside newer agents such as [[olanzapine]] and [[quetiapine]]. It has predominantly [[anticholinergic]] side effects, though [[extrapyramidal symptoms|extrapyramidal]] side effects are not uncommon either.
{{EH}}
 
'''Promazine''' (marketed as Sparine) is a medication that belongs to the [[phenothiazine]] class of [[antipsychotics]]. An older medication used to treat [[schizophrenia]], its use has largely been replaced by newer agents such as [[olanzapine]] and [[quetiapine]].
Promazine is not approved for human use in the United States.  It is available in the US for veterinary use under the names Promazine and Tranquazine.


It has predominantly [[anticholinergic]] side effects, though [[extrapyramidal]] side effects are not uncommon either.
==See also==
*[[Chlorpromazine]]
*[[Triflupromazine]]
*[[Prochlorperazine]]
*[[Trifluoperazine]]
*[[Fluphenazine]]
*[[Thioridazine]]
*[[Mesoridazine]]


{{Antipsychotics}}
{{Antipsychotics}}
{{Adrenergics}}
{{Cholinergics}}
{{Dopaminergics}}
{{Histaminergics}}
{{Tricyclics}}


{{SIB}}
[[Category:Phenothiazines]]
[[Category:Phenothiazines]]
[[pl:Promazyna]]
[[ru:Промазин]]


{{WH}}
{{nervous-system-drug-stub}}
{{WS}}

Revision as of 15:06, 9 April 2015

Promazine
Error creating thumbnail: File missing
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
MedlinePlusa600010
ATC code
Pharmacokinetic data
Protein binding94%
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC17H20N2S
Molar mass284.42 g/mol
3D model (JSmol)
  (verify)

Promazine (Sparine) is a medication that belongs to the phenothiazine class of antipsychotics. An older medication used to treat schizophrenia, it is still prescribed, alongside newer agents such as olanzapine and quetiapine. It has predominantly anticholinergic side effects, though extrapyramidal side effects are not uncommon either.

Promazine is not approved for human use in the United States. It is available in the US for veterinary use under the names Promazine and Tranquazine.

See also

Template:Tricyclics

Template:Nervous-system-drug-stub

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