Phenprobamate: Difference between revisions

Phenprobamate
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	M03BA01 (WHO) ;
Pharmacokinetic data
Elimination half-life	5 - 8 hours
Identifiers
	IUPAC name 3-Phenylpropylcarbamate;
CAS Number	673-31-4 ;
PubChem CID	4770;
ChemSpider	4606 ;
UNII	UJZ473TPS0;
KEGG	D01824 ;
ChEMBL	ChEMBL1079576 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C10H13NO2
Molar mass	179.22
3D model (JSmol)	Interactive image;
	SMILES O=C(OCCCc1ccccc1)N;
	InChI InChI=1S/C10H13NO2/c11-10(12)13-8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H2,11,12) ; Key:CAMYKONBWHRPDD-UHFFFAOYSA-N ;
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VisualWikitext

Revision as of 13:22, 13 April 2015

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-              __NOTOC__
-{{SI}}
-{{CMG}}
-==Overview==
-'''Phenprobamate''' (Gamaquil, Isotonil) is a centrally acting [[skeletal muscles|skeletal]] [[muscle relaxant]], with additional [[sedative]] and [[anticonvulsant]] effects. Overdose is similar to barbiturate. Its mechanism of action is probably similar to [[meprobamate]]. Phenprobamate was previously used in humans as an [[anxiolytic]], and is still sometimes used in general anaesthesia and for treating muscle cramps and spasticity.  Phenprobamate is still used in some european countries, but it has generally been replaced by newer drugs. Phenprobamate is metabolised by oxidative degradation of the [[amide]] group and ortho-hydroxylation of the benzene ring, and is eliminated in urine by the kidneys.
-Dose: 400 - 800 mg, up to 3 times a day
-==References==
-{{Reflist|2}}
-* [http://ctd.mdibl.org/voc.go?voc=chem&termUI=phenprobamate The Comparative Toxicogenomics Database: Phenprobamate]
-* [http://www.biam2.org/www/Sub884.html BIAM: Phenprobamate] (French).
-* [http://chembank.broad.harvard.edu/compounds/display.html?compound_id=2741&sets=bioactive&realm=bioactives&tab=formulations Chembank: Phenprobamate]
-* [http://ndt.oxfordjournals.org/cgi/content/full/17/5/941 Nephrology Dialysis Transplantation Volume 17, Number 5, Pp. 941. Letters: ''Haemoperfusion may be useful in phenprobamate and polypharmacy intoxication of paediatric patients.'']
-{{pharma-stub}}
-{{Muscle relaxants}}
-[[Category:Muscle relaxants]]
-[[Category:Drug]]

Phenprobamate: Difference between revisions

Revision as of 13:22, 13 April 2015

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