Acemetacin: Difference between revisions

	WikiDoc Resources for Acemetacin
Articles
Most recent articles on Acemetacin Most cited articles on Acemetacin Review articles on Acemetacin Articles on Acemetacin in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Acemetacin Images of Acemetacin Photos of Acemetacin Podcasts & MP3s on Acemetacin Videos on Acemetacin
Evidence Based Medicine
Cochrane Collaboration on Acemetacin Bandolier on Acemetacin TRIP on Acemetacin
Clinical Trials
Ongoing Trials on Acemetacin at Clinical Trials.gov Trial results on Acemetacin Clinical Trials on Acemetacin at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Acemetacin NICE Guidance on Acemetacin NHS PRODIGY Guidance FDA on Acemetacin CDC on Acemetacin
Books
Books on Acemetacin
News
Acemetacin in the news Be alerted to news on Acemetacin News trends on Acemetacin
Commentary
Blogs on Acemetacin
Definitions
Definitions of Acemetacin
Patient Resources / Community
Patient resources on Acemetacin Discussion groups on Acemetacin Patient Handouts on Acemetacin Directions to Hospitals Treating Acemetacin Risk calculators and risk factors for Acemetacin
Healthcare Provider Resources
Symptoms of Acemetacin Causes & Risk Factors for Acemetacin Diagnostic studies for Acemetacin Treatment of Acemetacin
Continuing Medical Education (CME)
CME Programs on Acemetacin
International
Acemetacin en Espanol Acemetacin en Francais
Business
Acemetacin in the Marketplace Patents on Acemetacin
Experimental / Informatics
List of terms related to Acemetacin

Acemetacin
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	M01AB11 (WHO) ;
Legal status
Legal status	UK: POM (Prescription only) ;
Identifiers
	IUPAC name 2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyacetic acid;
CAS Number	53164-05-9 ;
PubChem CID	1981;
ChemSpider	1904 ;
UNII	5V141XK28X;
KEGG	D01582 ;
ChEBI	CHEBI:31162;
ChEMBL	ChEMBL189171 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C21H18ClNO6
Molar mass	415.82372 g/mol
3D model (JSmol)	Interactive image;
	SMILES Clc1ccc(cc1)C(=O)n3c2ccc(OC)cc2c(c3C)CC(=O)OCC(=O)O;
	InChI InChI=1S/C21H18ClNO6/c1-12-16(10-20(26)29-11-19(24)25)17-9-15(28-2)7-8-18(17)23(12)21(27)13-3-5-14(22)6-4-13/h3-9H,10-11H2,1-2H3,(H,24,25) ; Key:FSQKKOOTNAMONP-UHFFFAOYSA-N ;
(verify)

Newer edit →

VisualWikitext

Revision as of 15:32, 13 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Acemetacin is a non-steroidal anti-inflammatory drug, used for the treatment of osteoarthritis, rheumatoid arthritis, lower back pain, and relieving post-operative pain. It is manufactured by Merck KGaA under the tradename Emflex, and is available in the UK as a prescription-only drug. Other brand names for acemetacin include Rheutrop (Austria), Acemetadoc, Acephlogont, Azeat, Rantudil (Germany, Mexico, Portugal), Gamespir (Greece), Oldan, Reudol (Spain), Tilur (Switzerland), Ost-map (Egypt).

Acemetacin, a glycolic acid ester of indometacin, acts as a prodrug; in the body, it is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. An advantage of acemetacin is that it reduces gastric damage when compared to indometacin.

References

@@ Line 55: / Line 55: @@
 }}
 __NOTOC__
 {{SI}}
 {{CMG}}
 ==Overview==
 '''Acemetacin''' is a [[non-steroidal anti-inflammatory drug]], used for the treatment of [[osteoarthritis]], [[rheumatoid arthritis]], lower back pain, and relieving post-operative pain. It is manufactured by [[Merck KGaA]] under the tradename '''Emflex''', and is available in the [[UK]] as a prescription-only drug. Other brand names for acemetacin include '''Rheutrop''' (Austria), '''Acemetadoc''', '''Acephlogont''', '''Azeat''', '''Rantudil''' (Germany, Mexico, Portugal), '''Gamespir''' (Greece), '''Oldan''', '''Reudol''' (Spain), '''Tilur''' (Switzerland), '''Ost-map''' (Egypt).
@@ Line 65: / Line 62: @@
 Acemetacin, a [[glycolic acid]] [[ester]] of [[indometacin]], acts as a [[prodrug]]; in the body, it is metabolized to [[indometacin]], which then acts as an inhibitor of [[cyclooxygenase]], producing the anti-inflammatory effects. An advantage of acemetacin is that it reduces gastric damage when compared to indometacin.
 ==References==
 {{reflist|2}}
@@ Line 71: / Line 67: @@
 {{Analgesics}}
-[[Category:Methyl indoles]]
-[[Category:Acetic acids]]
 [[Category:Amides]]
 [[Category:Phenol ethers]]

v t e Nonsteroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
Pyrazolones / Pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Difenamizole Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone^‡
Salicylates	Aspirin (acetylsalicylic acid)^# Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate
Acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bumadizone Bufexamac Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indometacin Indometacin farnesil Isoxepac Ketorolac Lonazolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac^†
Oxicams	Ampiroxicam Droxicam Isoxicam Lornoxicam Meloxicam Piroxicam Tenoxicam
Propionic acid derivatives (profens)	Alminoprofen Benoxaprofen^† Carprofen^‡ Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen^# Ibuproxam Indoprofen^† Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Pirprofen Suprofen Tarenflurbil Tepoxalin^‡ Tiaprofenic acid Vedaprofen^‡ Zaltoprofen COX-inhibiting nitric oxide donator: Naproxcinod
N-Arylanthranilic acids (fenamates)	Azapropazone Clonixin Etofenamate Flufenamic acid Flunixin Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid Flutiazin
Coxibs	Apricoxib Celecoxib Cimicoxib^‡ Deracoxib^‡ Etoricoxib Firocoxib^‡ Lumiracoxib^† Mavacoxib^‡ Parecoxib Robenacoxib^‡ Rofecoxib^† Valdecoxib^†
Other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase/Orgotein Tenidap
Items listed in bold indicate initially developed compounds of specific groups. ^#WHO-EM ^†Withdrawn drugs. ^‡Veterinary use medications.

v t e Analgesic products (N02A, N02B)
Opioids See also: Opioids template	Alphaprodine · Anileridine · Buprenorphine · Butorphanol · Codeine · Dextromoramide · Dextropropoxyphene · Dezocine · Desomorphine · Diamorphine · Dihydrocodeine · Dihydromorphine · Fentanyl · Hydrocodone · Hydromorphone · Ketobemidone · Levorphanol · Meptazinol · Methadone · Morphine · Nalbuphine · Nicomorphine · Opium · Oxycodone · Oxymorphone · Pethidine · Pentazocine · Pethidine · Piminodine · Piritramide · Tilidine · Tramadol · Tapentadol
Salicylic acid and derivatives	Aspirin (Acetylsalicylic Acid) · Benorylate · Diflunisal · Ethenzamide · Magnesium Salicylate · Salicin · Salicylamide · Salsalate · See also: NSAIDs
Pyrazolones	Ampyrone/Aminophenazone · Metamizole · Phenazone
Cannabinoids	Cannabis · Tetrahydrocannabinol · AM404
Anilides	Paracetamol (acetaminophen) · Phenacetin · Propacetamol
Non-Salicylate Non-Steroidal Anti-Inflammatories See also: NSAIDs template	Template:Navbox subgroup
Atypical, Adjunct & Miscellaneous	Bicifadine · Clonidine · Cyclobenzaprine · Duloxetine · Flupirtine · Gabapentin · Nefopam · Orphenadrine · Trazadone · Ziconotide

Acemetacin: Difference between revisions

Revision as of 15:32, 13 April 2015

Overview

References

Navigation menu

Search