Bone morphogenetic protein 2

Bone morphogenetic protein 2
PDB rendering based on 3bmp.
Identifiers
Symbols	BMP2 ; BMP2A
External IDs	Template:OMIM5 Template:MGI HomoloGene: 926
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

WikiDoc Resources for Bone morphogenetic protein 2
Articles
Most recent articles on Bone morphogenetic protein 2 Most cited articles on Bone morphogenetic protein 2 Review articles on Bone morphogenetic protein 2 Articles on Bone morphogenetic protein 2 in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Bone morphogenetic protein 2 Images of Bone morphogenetic protein 2 Photos of Bone morphogenetic protein 2 Podcasts & MP3s on Bone morphogenetic protein 2 Videos on Bone morphogenetic protein 2
Evidence Based Medicine
Cochrane Collaboration on Bone morphogenetic protein 2 Bandolier on Bone morphogenetic protein 2 TRIP on Bone morphogenetic protein 2
Clinical Trials
Ongoing Trials on Bone morphogenetic protein 2 at Clinical Trials.gov Trial results on Bone morphogenetic protein 2 Clinical Trials on Bone morphogenetic protein 2 at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Bone morphogenetic protein 2 NICE Guidance on Bone morphogenetic protein 2 NHS PRODIGY Guidance FDA on Bone morphogenetic protein 2 CDC on Bone morphogenetic protein 2
Books
Books on Bone morphogenetic protein 2
News
Bone morphogenetic protein 2 in the news Be alerted to news on Bone morphogenetic protein 2 News trends on Bone morphogenetic protein 2
Commentary
Blogs on Bone morphogenetic protein 2
Definitions
Definitions of Bone morphogenetic protein 2
Patient Resources / Community
Patient resources on Bone morphogenetic protein 2 Discussion groups on Bone morphogenetic protein 2 Patient Handouts on Bone morphogenetic protein 2 Directions to Hospitals Treating Bone morphogenetic protein 2 Risk calculators and risk factors for Bone morphogenetic protein 2
Healthcare Provider Resources
Symptoms of Bone morphogenetic protein 2 Causes & Risk Factors for Bone morphogenetic protein 2 Diagnostic studies for Bone morphogenetic protein 2 Treatment of Bone morphogenetic protein 2
Continuing Medical Education (CME)
CME Programs on Bone morphogenetic protein 2
International
Bone morphogenetic protein 2 en Espanol Bone morphogenetic protein 2 en Francais
Business
Bone morphogenetic protein 2 in the Marketplace Patents on Bone morphogenetic protein 2
Experimental / Informatics
List of terms related to Bone morphogenetic protein 2

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Bone morphogenetic protein 2 or BMP-2 is a protein that belongs to the TGF-β superfamily of proteins. It, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. It is involved in the Hedgehog pathway, TGF-beta signaling pathway, and the Cytokine-cytokine receptor interaction. It is involved also in cardiac cell differentiation and epithelial to mesenchymal transition.

BMP-2 and BMP-7 are osteogenic BMPs: they have been demonstrated to potently induce osteoblast differentiation in a variety of cell types.

Medical Uses

Bone morphogenetic protein 2 has been shown to stimulate the production of bone and recombinant human protein (rhBMP-2) and is currently available for orthopaedic usage in the United States. Implantation of BMP-2 in a collagen sponge induces new bone formation and can be used for the treatment of bony defects, delayed union, and non-union.

Further reading

• Nickel J, Dreyer MK, Kirsch T, Sebald W (2001). "The crystal structure of the BMP-2:BMPR-IA complex and the generation of BMP-2 antagonists". The Journal of bone and joint surgery. American volume. 83-A Suppl 1 (Pt 1): S7–14. PMID 11263668.CS1 maint: Multiple names: authors list (link)
• Kawamura C, Kizaki M, Ikeda Y (2003). "Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells". Leuk. Lymphoma. 43 (3): 635–9. PMID 12002771.CS1 maint: Multiple names: authors list (link)
• Marie PJ, Debiais F, Haÿ E (2003). "Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling". Histol. Histopathol. 17 (3): 877–85. PMID 12168799.CS1 maint: Multiple names: authors list (link)

External links

• Online Mendelian Inheritance in Man record: Online Mendelian Inheritance in Man (OMIM) 112261

Template:WikiDoc Sources