Clostridium difficile infection historical perspective: Difference between revisions

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Revision as of 13:30, 21 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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 ==Overview==
-*''Clostridium difficile'' was first isolated during an experiment in 1935 from health neonates. Following isolation, the bacterium was originally named ''Bacillus difficilis''.
-*The bacterium was named difficile because isolation process during the original experiment was difficult.
-*The association between ''C. difficile'' and antibiotic-associated diarrhea was first made in 1978 following among patients exposed to clindamycin.
-*In 2003, a resistant, hypervirulent strain of ''C. difficile'' (NAP/BI/027 strain) with increased synthesis of toxins A and B was first identified. The emergence of the new strain was attributed to fluoroquinolone administration.
 ==Historical Perspective==