Infectious Disease Project Organ-Based Infections Musculoskeletal System: Difference between revisions

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==''WikiDoc Infectious Disease Project'' — Organ-Based Infections==
==''WikiDoc Infectious Disease Project'' — Organ-Based Infections==
''' Musculoskeletal'''
===Osteomyelitis===
: Osteomyelitis
 
:: Candidal osteomyelitis
====Candidal osteomyelitis====
:: Chronic osteomyelitis
{{Rx|Preferred Regimen}}
:: Contiguous with vascular insufficiency
* '''[[Fluconazole]]''' 400 mg (6 mg/kg) IV/po daily {{or}} '''[[Lipid-based Amphotericin B]]''' 3-5 mg/kg daily for two weeks, followed by '''[[Fluconazole]]'''
:: Contiguous without vascular insufficiency
</li>
:: Diabetic foot
{{Rx|Alternative Regimen}}
:: Foot bone
* '''[[Caspofungin]]''' 70 mg loading dose, then 50 mg/day IV {{or}} '''[[Micafungin]]''' 100 mg/day IV or Anidulafungin 200 mg IV loading dose, then 100 mg/day IV
:: Foot puncture wound
</li>
:: Hematogenous
 
:: Hemoglobinopathy
====Chronic osteomyelitis====
:: Prosthetic joint infection
{{Rx|Preferred Regimen}}
:: Spinal implant
* '''[[Systemic antibiotics]]''' per culture and susceptibility results {{and}}
:: Sternal
* '''[[Surgical debridement]]'''
: Bursitis
</li>
: Lyme arthritis
 
: Reactive arthritis
====Contiguous with vascular insufficiency====
:: Reiter's syndrome
{{Rx|Preferred Regimen}}
:: Post-streptococcal arthritis
* '''[[Systemic antibiotics]]''' per culture and susceptibility results {{and}}
: Septic arthritis
* '''[[Surgical debridement]]''' {{and}}
:: Brucellosis
* '''[[Revascularization]]''' if possible
:: Candida
</li>
:: Gonococcal, disseminated infection
 
:: Gram-negative bacilli
====Contiguous without vascular insufficiency====
:: Histoplasmosis
{{Rx|Preferred Regimen}}
:: Lyme disease
* '''[[Vancomycin]]''' 1 gm IV q12h {{and}}
:: Mycobacterium tuberculosis
* '''[[Ceftazidime]]''' 2 gm IV q8h {{or}} '''[[Cefepime]]''' 2 gm IV q12h
:: Pneumococcal
</li>
:: Staphylococcal
{{Rx|Alternative Regimen}}
:: Streptococcal
* '''[[Linezolid]]''' 600 mg po/IV bid {{and}}
:: Post-intraarticular injection
* '''[[Ceftazidime]]''' 2 gm IV q8h {{or}} '''[[Cefepime]]''' 2 gm IV q12h
: Gangrene
</li>
: Myonecrosis
{{Rx|Gram-negative bacilli}}
: Necrotizing fascitis
* '''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Linezolid]]''' 600 mg po/IV bid
:: Clostridial
</li>
:: Staphylococcal
{{Rx|Staphylococcus aureus (MRSA/MSSA)}}
:: Streptococcal
* '''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Levofloxacin]]''' 750 mg po once daily if susceptible {{and}}
:: Synergistic
* '''[[Rifampin]]''' 300-450 mg po bid {{or}} '''[[Rifampin]]''' 600 mg po once daily if susceptible
: Pyomyositis
</li>
{{Rx|MSSA}}
* '''[[Nafcillin]]''' 2 gm IV q4h {{or}} '''[[Oxacillin]]''' 2 gm IV q4h {{or}} '''[[Cefazolin]]''' 2 gm IV q8h
</li>
{{Rx|MRSA}}
* '''[[Vancomycin]]''' 15-20 mg/kg IV q8-12h targeting trough concentrations of 15-20 mg/L
</li>
 
====Diabetic foot====
{{Rx|Chronic infection}}
* '''[[Levofloxacin]]''' 750 mg IV/PO q24h {{or}} '''[[Cefoxitin]]''' 1 g IV q4h (or 2 g IV q6–8h) {{or}} '''[[Ceftriaxone]]''' 1–2 g/day IV/IM q12–24h {{or}} '''[[Ampicillin-Sulbactam]]''' 1.5–3 g IV/IM q6h {{or}} '''[[Moxifloxacin]]''' 400 mg IV/PO q24h {{or}} '''[[Ertapenem]]''' 1 g IV/IM q24h {{or}} '''[[Tigecycline]]''' 100 mg IV, then 50 mg IV q12h {{or}} '''[[Imipenem-Cilastatin]]''' 0.5–1 g IV q6–8h
</li>
{{Rx|Recent antibiotic use}}
* '''[[Levofloxacin]]''' 750 mg IV/PO q24h {{or}} '''[[Cefoxitin]]''' 1 g IV q4h (or 2 g IV q6–8h) {{or}} '''[[Ceftriaxone]]''' 1–2 g/day IV/IM q12–24h {{or}} '''[[Ampicillin-Sulbactam]]''' 1.5–3 g IV/IM q6h {{or}} '''[[Moxifloxacin]]''' 400 mg IV/PO q24h {{or}} '''[[Ertapenem]]''' 1 g IV/IM q24h {{or}} '''[[Tigecycline]]''' 100 mg IV, then 50 mg IV q12h {{or}} '''[[Imipenem-Cilastatin]]''' 0.5–1 g IV q6–8h
</li>
{{Rx|High Risk for MRSA}}
* '''[[Linezolid]]''' 600 mg IV/PO q12h {{or}} '''[[Daptomycin]]''' 4 mg/kg IV q24h {{or}} '''[[Vancomycin]]''' 15–20 mg/kg IV q8–12h (trough: 10–20 mg/L)
</li>
{{Rx|High Risk for Pseudomonas aeruginosa}}
* '''[[Piperacillin–Tazobactam]]''' 3.375 g IV q6–8h
</li>
{{Rx|Polymicrobial Infection}}
* ('''[[Vancomycin]]''' 15–20 mg/kg IV q8–12h {{or}} '''[[Linezolid]]''' 600 mg IV/PO q12h {{or}} '''[[Daptomycin]]''' 4 mg/kg IV q24h) {{and}}
* ('''[[Piperacillin–Tazobactam]]''' 3.375 g IV q6–8h {{or}} '''[[Imipenem-Cilastatin]]''' 0.5–1 g IV q6–8h {{or}} '''[[Ertapenem]]''' 1 g IV/IM q24h {{or}} '''[[Meropenem]]''' 1 g IV/IM q24h) {{or}} ('''[[Metronidazole]]''' 15 mg/kg IV, then 7.5 mg/kg IV q6h {{plus}} '''[[Ceftazidime]]''' 2 g IV q8h {{or}} '''[[Cefepime]]''' 2 g IV q8h {{or}} '''[[Aztreonam]]''' 2 g IV q6–8h)
</li>
 
====Foot bone====
{{Rx|Preferred Regimen}}
* '''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Levofloxacin]]''' 750 mg po q24h
</li>
{{Rx|Alternative Regimen}}
* '''[[Ceftazidime]]''' 2 gm IV q8h {{or}} '''[[Cefepime]]''' 2 gm IV q8h {{or}} '''[[Meropenem]]''' 1 gm IV q8h
</li>
 
====Foot puncture wound====
{{Rx|Preferred Regimen}}
* '''Cleanse wound''' {{and}}
* '''Tetanus booster''' if due {{and}}
* '''X-ray''' to exclude presence of radio-opaque foreign body
</li>
 
====Hematogenous====
{{Rx|Preferred Regimen}}
* MRSA likely – '''[[Vancomycin]]''' 15–20 mg/kg IV q8–12h {{and2}} ('''[[Ceftriaxone]]''' 1–2 g/day IV/IM q12–24h {{or}} '''[[Ceftazidime]]''' 2 gm IV q8h {{or}} '''[[Cefepime]]''' 2 gm IV q12h)
* MRSA unlikely – ('''[[Nafcillin]]''' {{or}} '''[[Oxacillin]]''') {{and2}} ('''[[Ceftriaxone]]''' 1–2 g/day IV/IM q12–24h {{or}} '''[[Ceftazidime]]''' 2 gm IV q8h {{or}} '''[[Cefepime]]''' 2 gm IV q12h)
</li>
{{Rx|Alternative Regimen}}
* '''[[Linezolid]]''' 600 mg po/IV bid {{or}} '''[[Daptomycin]]''' 4 mg/kg IV q24h to replace vancomycin
* '''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Levofloxacin]]''' 750 mg IV/PO q24h {{or}} '''[[Aztreonam]]''' 2 g IV q6–8h to replace a third-generation cephalosporin
</li>
 
====Hemoglobinopathy====
{{Rx|Preferred Regimen}}
* '''[[Ciprofloxacin]]''' 400 mg IV q12h {{or}} '''[[Ceftriaxone]]''' 2 gm IV q24h
</li>
{{Rx|Alternative Regimen}}
* '''[[Ciprofloxacin]]''' 750 mg po bid for 6 weeks {{or}} '''[[Levofloxacin]]''' 750 mg po q24h for 6 weeks
</li>
 
====Prosthetic joint infection====
{{Rx|MSSA/MSSE}}
* ('''[[Nafcillin]]''' 2 gm IV q4h {{or}} '''[[Oxacillin]]''' 2 gm IV q4h IV) {{plus}} '''[[Rifampin]]''' 300 mg po bid {{or2}}
* '''[[Cefazolin]]''' 2 gm IV q8h {{plus}} '''[[Rifampin]]''' 300 mg po bid for 2-6 weeks followed by ('''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Levofloxacin]]''' 750 mg po q24h) {{plus}} '''[[Rifampin]]''' 300 mg po bid for 3-6 months
</li>
{{Rx|MRSA/MRSE}}
* '''[[Vancomycin]]''' 15-20 mg/kg IV q8-12h {{plus}} '''[[Rifampin]]''' 300 mg po bid for 2-6 weeks followed by ('''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Levofloxacin]]''' 750 mg po q24h) {{plus}} '''[[Rifampin]]''' 300 mg po bid for 3-6 months
</li>
{{Rx|Streptococcus}}
* '''[[Penicillin G]]''' 20 million units IV continuous infusion q24h or in 6 divided doses {{or}} '''[[Ceftriaxone]]''' 2 gm IV q24h x 4-6 weeks
</li>
{{Rx|Enterococcus}}
* Penicillin-susceptible – '''[[Ampicillin]]''' 12 gm IV {{or}} '''[[Penicillin G]]''' 20 million units IV continuous infusion q24h or in 6 divided doses x 4-6 weeks
* Penicillin-resistant – '''[[Vancomycin]]''' 15 mg/kg IV q12h x 4-6 week
</li>
{{Rx|Propionibacterium acnes}}
* '''[[Penicillin G]]''' 20 million units IV continuous infusion or in 6 divided doses {{or}} '''[[Ceftriaxone]]''' 2 gm IV q24h x 4-6 weeks
</li>
{{Rx|Gram-negative enteric bacilli}}
* '''[[Ertapenem]]''' 1 gm q24h IV {{or}} '''[[Ceftriaxone]]''' 2 gm IV q24h {{or}} '''[[Cefepime]]''' 2 gm IV q12h for 4-6 weeks
</li>
{{Rx|Pseudomonas aeruginosa}}
* '''[[Cefepime]]''' 2 gm IV q12h {{or}} '''[[Meropenem]]''' 1 gm IV q8h for 4-6 weeks {{and}}
* '''[[Tobramycin]]''' 5.1 mg/kg once daily IV for 4-6 weeks
</li>
 
====Spinal implant====
{{Rx|MSSA/MSSE}}
* ('''[[Nafcillin]]''' 2 gm IV q4h {{or}} '''[[Oxacillin]]''' 2 gm IV q4h IV) {{plus}} '''[[Rifampin]]''' 300 mg po bid {{or2}}
* '''[[Cefazolin]]''' 2 gm IV q8h {{plus}} '''[[Rifampin]]''' 300 mg po bid for 2-6 weeks followed by ('''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Levofloxacin]]''' 750 mg po q24h) {{plus}} '''[[Rifampin]]''' 300 mg po bid for 3-6 months
</li>
{{Rx|MRSA/MRSE}}
* '''[[Vancomycin]]''' 15-20 mg/kg IV q8-12h {{plus}} '''[[Rifampin]]''' 300 mg po bid for 2-6 weeks followed by ('''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Levofloxacin]]''' 750 mg po q24h) {{plus}} '''[[Rifampin]]''' 300 mg po bid for 3-6 months
</li>
{{Rx|Streptococcus}}
* '''[[Penicillin G]]''' 20 million units IV continuous infusion q24h or in 6 divided doses {{or}} '''[[Ceftriaxone]]''' 2 gm IV q24h x 4-6 weeks
</li>
{{Rx|Enterococcus}}
* Penicillin-susceptible – '''[[Ampicillin]]''' 12 gm IV {{or}} '''[[Penicillin G]]''' 20 million units IV continuous infusion q24h or in 6 divided doses x 4-6 weeks
* Penicillin-resistant – '''[[Vancomycin]]''' 15 mg/kg IV q12h x 4-6 week
</li>
{{Rx|Propionibacterium acnes}}
* '''[[Penicillin G]]''' 20 million units IV continuous infusion or in 6 divided doses {{or}} '''[[Ceftriaxone]]''' 2 gm IV q24h x 4-6 weeks
</li>
{{Rx|Gram-negative enteric bacilli}}
* '''[[Ertapenem]]''' 1 gm q24h IV {{or}} '''[[Ceftriaxone]]''' 2 gm IV q24h {{or}} '''[[Cefepime]]''' 2 gm IV q12h for 4-6 weeks
</li>
{{Rx|Pseudomonas aeruginosa}}
* '''[[Cefepime]]''' 2 gm IV q12h {{or}} '''[[Meropenem]]''' 1 gm IV q8h for 4-6 weeks {{and}}
* '''[[Tobramycin]]''' 5.1 mg/kg once daily IV for 4-6 weeks
</li>
 
====Sternal====
{{Rx|Preferred Regimen}}
* '''[[Vancomycin]]''' 15-30 mg/kg IV q 8-12h targeting trough of 15-20 μg/mL {{or}} '''[[Nafcillin]]''' 2 gm IV q4h
</li>
{{Rx|Alternative Regimen}}
* '''[[Linezolid]]''' 600 mg IV/po bid
</li>
 
===Bursitis===
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
 
===Lyme arthritis===
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
 
===Reactive arthritis===
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Reiter's syndrome====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Post-streptococcal arthritis====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
===Septic arthritis===
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Brucellosis====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Candida====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Gonococcal, disseminated infection====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Gram-negative bacilli====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Histoplasmosis====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Lyme disease====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Mycobacterium tuberculosis====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Pneumococcal====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Staphylococcal====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Streptococcal====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Post-intraarticular injection====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
===Gangrene===
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
 
===Myonecrosis===
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
===Necrotizing fascitis===
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Clostridial====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Staphylococcal====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Streptococcal====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
====Synergistic====
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
===Pyomyositis===
{{Rx|Preferred Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
{{Rx|Alternative Regimen}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}}
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration
</li>
 
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Revision as of 02:44, 13 May 2015

    Mission Statement    
    Antimicrobial Agents    
    Organ-Based Infections    
    Pathogen-Based Infections    

WikiDoc Infectious Disease Project — Organ-Based Infections

Osteomyelitis

Candidal osteomyelitis

    • Caspofungin 70 mg loading dose, then 50 mg/day IV OR Micafungin 100 mg/day IV or Anidulafungin 200 mg IV loading dose, then 100 mg/day IV
  • Chronic osteomyelitis

  • Contiguous with vascular insufficiency

  • Contiguous without vascular insufficiency

    • Vancomycin 15-20 mg/kg IV q8-12h targeting trough concentrations of 15-20 mg/L
  • Diabetic foot

  • Foot bone

  • Foot puncture wound

    • Cleanse wound AND
    • Tetanus booster if due AND
    • X-ray to exclude presence of radio-opaque foreign body
  • Hematogenous

  • Hemoglobinopathy

  • Prosthetic joint infection

    • Penicillin G 20 million units IV continuous infusion q24h or in 6 divided doses OR Ceftriaxone 2 gm IV q24h x 4-6 weeks
    • Penicillin-susceptible – Ampicillin 12 gm IV OR Penicillin G 20 million units IV continuous infusion q24h or in 6 divided doses x 4-6 weeks
    • Penicillin-resistant – Vancomycin 15 mg/kg IV q12h x 4-6 week
  • Spinal implant

    • Penicillin G 20 million units IV continuous infusion q24h or in 6 divided doses OR Ceftriaxone 2 gm IV q24h x 4-6 weeks
    • Penicillin-susceptible – Ampicillin 12 gm IV OR Penicillin G 20 million units IV continuous infusion q24h or in 6 divided doses x 4-6 weeks
    • Penicillin-resistant – Vancomycin 15 mg/kg IV q12h x 4-6 week
  • Sternal

  • Bursitis

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Lyme arthritis

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Reactive arthritis

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Reiter's syndrome

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Post-streptococcal arthritis

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Septic arthritis

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Brucellosis

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Candida

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Gonococcal, disseminated infection

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Gram-negative bacilli

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Histoplasmosis

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Lyme disease

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Mycobacterium tuberculosis

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Pneumococcal

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Staphylococcal

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Streptococcal

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Post-intraarticular injection

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Gangrene

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Myonecrosis

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Necrotizing fascitis

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Clostridial

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Staphylococcal

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Streptococcal

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Synergistic

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
  • Pyomyositis

    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
    • Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration