Cryoglobulinemia other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]

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Other Diagnostic Studies

Skin Biopsy

Skin biopsy can be of value in establishing the diagnosis.

Renal Biopsy

• The characteristic findings on renal biopsy are

  1. Intraluminal thrombi
  2. Diffuse IgM deposition in the capillary loops
  3. Subendothelial deposits in a “curvilinear” pattern on EM.

• Only 14% develop end stage renal disease (ESRD) at 10 years after a renal biopsy demonstrates MC.
• Recurrent MC can affect up to 70% of transplanted kidneys, but does not preclude transplantation since most of these grafts do not fail.

References

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