Silicosis medical therapy: Difference between revisions
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===Management of Acute Silicosis=== | ===Management of Acute Silicosis=== | ||
*A modest short-term randomized clinical trial demonstrated that systemic steroids may be effective in the management of steroids, but the benefit has not been well-established<ref name="pmid1735256">{{cite journal| author=Goodman GB, Kaplan PD, Stachura I, Castranova V, Pailes WH, Lapp NL| title=Acute silicosis responding to corticosteroid therapy. | journal=Chest | year= 1992 | volume= 101 | issue= 2 | pages= 366-70 | pmid=1735256 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1735256 }} </ref> | *A modest short-term randomized clinical trial demonstrated that [[systemic steroids]] may be effective in the management of [[steroids]], but the benefit has not been well-established<ref name="pmid1735256">{{cite journal| author=Goodman GB, Kaplan PD, Stachura I, Castranova V, Pailes WH, Lapp NL| title=Acute silicosis responding to corticosteroid therapy. | journal=Chest | year= 1992 | volume= 101 | issue= 2 | pages= 366-70 | pmid=1735256 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1735256 }} </ref> | ||
*Whole-lung lavage is recommended in acute silicosis to improve gas exchange and eliminate residual alveolar debris, although not routinely recommended because of the ill effects. | *[[Lung lavage|Whole-lung lavage]] is recommended in acute silicosis to improve gas exchange and eliminate residual alveolar debris, although not routinely recommended because of the ill effects<ref name="pmid23632425">{{cite journal| author=Stafford M, Cappa A, Weyant M, Lara A, Ellis J, Weitzel NS et al.| title=Treatment of acute silicoproteinosis by whole-lung lavage. | journal=Semin Cardiothorac Vasc Anesth | year= 2013 | volume= 17 | issue= 2 | pages= 152-9 | pmid=23632425 | doi=10.1177/1089253213486524 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23632425 }} </ref> | ||
===Management of Chronic Silicosis=== | ===Management of Chronic Silicosis=== | ||
Revision as of 18:38, 23 June 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Silicosis is an irreversible condition with currently no cure. Treatment options currently focus on alleviating the symptoms and preventing complications.
Medical Therapy
- There is no evidence-based medical therapy for the treatment of silicosis.
- Generally, management of silicosis aims to manage other respiratory comorbidities (e.g. COPD or tuberculosis) and to treat silicosis-associated complications.
- Management goals include avoidance of exposure to silica, optimization of respiratory function, and preventive care.
Management of Acute Silicosis
- A modest short-term randomized clinical trial demonstrated that systemic steroids may be effective in the management of steroids, but the benefit has not been well-established[1]
- Whole-lung lavage is recommended in acute silicosis to improve gas exchange and eliminate residual alveolar debris, although not routinely recommended because of the ill effects[2]
Management of Chronic Silicosis
- Systemic steroid therapy are not recommended for the indication of chronic silicosis alone.
- However, systemic steroids may be administered to patients who are diagnosed with silicosis and have other indications for the use of steroids.
Supportive therapy
- Smoking cessation
- Supplemental oxygen is administered to prevent complications of chronic hypoxemia
- Bronchodilators may facilitate breathing if airflow limitation is present on spirometry.
References
- ↑ Goodman GB, Kaplan PD, Stachura I, Castranova V, Pailes WH, Lapp NL (1992). "Acute silicosis responding to corticosteroid therapy". Chest. 101 (2): 366–70. PMID 1735256.
- ↑ Stafford M, Cappa A, Weyant M, Lara A, Ellis J, Weitzel NS; et al. (2013). "Treatment of acute silicoproteinosis by whole-lung lavage". Semin Cardiothorac Vasc Anesth. 17 (2): 152–9. doi:10.1177/1089253213486524. PMID 23632425.