Fatigue causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: M.Umer Tariq [2]

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Common Causes

• Allergic rhinitis
• Antidepressants
• Antihypertensives
• Anxiety
• Chronic fatigue syndrome
• Depression
• Hypnotics
• Hypothyroidism
• Malnutrition
• Occult malignancy
• Severe anemia

Causes by Organ System

Cardiovascular	angina pectoris, atrial fibrillation, cardiac amyloidosis, cardiogenic shock, cerebrovascular arteriosclerosis, cholesterol pericarditis, congenital heart disease, congestive heart failure, constrictive pericarditis, coronary artery disease, coronary artery fistula, double outlet right ventricle, giant cell arteritis, hypertensive heart disease, hypertrophic cardiomyopathy, hypotension, inappropriate sinus tachycardia, infective endocarditis, mitral stenosis, mitral valve prolapse, myocardial infarction, pericardial constriction, postural orthostatic tachycardia syndrome, right ventricular outflow tract obstruction, sick sinus syndrome, subacute bacterial endocarditis, tricuspid regurgitation, trifascicular block, ventricular septal defect, wolff-parkinson-white syndrome, amyloidosis, aortic stenosis, asymmetric septal hypertrophy, atrial myxoma, familial, austrian syndrome, bacterial endocarditis, barth syndrome, calcium deficiency, cardiac malformation, cardiogenic shock, central sleep apnea, cerebrovascular arteriosclerosis, constrictive pericarditis, coronary artery disease, coronary artery fistula, decreased oxygen saturation, dilated cardiomyopathy, double outlet right ventricle, dressler syndrome, ebstein's anomaly, endocarditis, heart attack, heart block
Chemical / poisoning	1,3-Dichloropropene, amidithion, antifreeze, azinfosethyl, azinophos-methyl, azothoate, bifenthrin, bioallethrin, biphenyl, brodifacoum, bromadiolone, bromophos, cadmium, cadusafos, carbon monoxide poisoning, carbophenothion, chemical pneumonia, chlorfenvinphos, chlorinated naphthalene, chloromethane, chlorophacinone rodenticide poisoning, chloropyrifos, ciguatera, ciguatera, coumachlor rodenticide poisoning, coumafuryl rodenticide poisoning, coumatetralyl rodenticide poisoning, cyanthoate , cyclohexanone, cyclohexylamine, cyfluthrin, deltamethrin, demeton, difenacoum rodenticide poisoning, demeton-methyl, difethialone rodenticide poisoning, dimethoate, endothion, ethion, ethoate-methyl, ethoprophos, ethyl-guthion, ethylbenzene, ethylene, etrimfos, fenchlorphos, fenitrothion, fenthion, fenvalerate, finale rodenticide poisoning, flocoumafen rodenticide poisoning , folgorat rodenticide poisoning , fonophos, formothion, foxglove poisoning, guthion (ethyl), havoc rodenticide poisoning, heavy metal poisoning, lead, monocrotophos, naphthalene, silicosis
Dermatologic	Dermatomyositis , erysipelas, erythema chronicum migrans , essential thrombocytopenia, pityriasis rosea
Drug Side Effect	Acetaminophen, aciclovir, adderall, aldesleukin ,alprazolam, altretamine, amikacin Sulfate Injection, amiloride and hydrochlorothiazide, amiton, amlodipine and benazepril, aprepitant, auranofin, azelastine, barbiturate,betablockers,bezafibrate, botulinum toxin, bromopride, busulfan, carboplatin, carfilzomib, carmustine, tenofovir disoproxil fumarate,carboplatin, caspofungin acetate, cerivastatin, chlorambucil, chloropyramine, citalopram, citrulline, cladribine, clobenzorex, clomipramine, clonidine, crizotinib, cyclobenzaprine, cytarabine , dacarbazine, dantrolene oral, daunorubicin, delavirdine, denileukin diftitoxdepo-provera, desloratadine, desmopressin, dexedrine overdose ,dextromethorphan hydrobromide, diborane, diflunisal, dobutamine hydrochloride Injection, docetaxel, doxepin, doxorubicin, duloxetine, ecallantide, efavirenz, emtricitabine, eliglustat, eslicarbazepine acetate, etoposide, exemestane, ezetimibe/simvastatin, febuxostat, fenofibrate, floxuridine, fluconazole Injection, eltrombopag, enzalutamide, eribulin, fludarabine phosphate, fluorouracil, gemcitabine Hydrochloride, gentamicin Sulfate Injection, grifulvin V, griseofulvin, guanfacine, antihistamine, histrelin, Ibrutinib, Idarubicin, Ifosfamide, Imiglucerase, Imiquimod, Indapamide, Interferon alfa-2a and alfa-2b Injection, Interferon alfa 2b , Interferon-gamma, Interferon Gamma-1b Injection, Ipilimumab, Itraconazole, Ivermectin, Ixabepilone, labetalol, lamivudine, lamotrigine, lapatinib, lenalidomide, letrozole, levetiracetamlevocetirizine, levonorgestrel, levothyroxine, leuprolide, lisinopril and hydrochlorothiazide, lorcaserin, lomustine, loperamide, loratadine, maprotiline, mechlorethamine, medroxyprogesterone, melatonin, meloxicam, mercaptopurine, meropenem Injection, mesna, methotrexate Injection, metoclopramide hydrochloride Injection, mifepristone, mitomycin, molybdenum, moxonidine, mycophenolic acid, nadolol, natalizumab, nebivolol, nitrazepam, oprelvekin, Oxaliplatin, Oxcarbazepine, Paclitaxel, Palbociclib, Panitumumab, Pantothenic acid, Pasireotide, pazopanib hydrochloride, Pegaspargase, pegylated interferon alfa-2a, pentamidine Inhalation, pentostatin, perampanel, perindopril, pertuzumab, phenelzine, pilocarpine,pirfenidone, plerixafor, plicamycin, praziquantel, procarbazine, progesterone, promethazine, potassium Iodide, quazepam, quinapril, quinidine oral, radafaxine, ramelteon, reserpine, rifabutin, rilmenidine,rilpivirine, ritonavir, rizatriptan, romiplostim, rufinamide, sargramostim Injection, sipuleucel-T, streptozocin, sumatriptan, sunitinib, Temozolomide, Teniposide, Terazosin, Thalidomide, Thiabendazole, thiazide, thioguanine, thiotepa, tinidazole, tobramycin sulfate Injection, topiramate, topotecan hydrochloride, torsemide Injection, torsemide oral, tralomethrin, trametinib dimethyl sulfoxide, trandolapril, trastuzumab, trazodone, trepanation, trestolone, triazolam, trimetrexate glucuronate, trovafloxacin, valaciclovir, valproic Acid, venlafaxine, vandetanibvicodin, vigabatrin, vinblastine, vinorelbine Tartrate, Vorinostat, Zalcitabine, Zidovudine Injection, Zileuton, Zoledronate, Zopiclone
Ear Nose Throat	Acute viral nasopharyngitis (common cold), sinusitis,
Endocrine	Addison's disease, conn's Syndrome, cushing's Disease, diabetes mellitus, empty sella syndrome, Graves' Disease, Hashimoto's thyroiditis, hyperparathyroidism, hyperthyroidism, hypogonadism, hypopituitarism, hypothyroidism,
Environmental	No underlying causes
Gastroenterologic	Accessory pancreas, ascites, celiac disease, chronic Liver Disease, chronic pancreatitis, cirrhosis, crohn's disease, gastric dumping syndrome, gastric lymphoma, gastroenteritis, Gastrointestinal bleeding, hepatitis A, hepatitis C, Inflammatory Bowel Disease, Irritable bowel syndrome, Pseudomembranous colitis, ulcerative colitis,
Genetic	Barth syndrome, Becker's muscular dystrophy, Engelmann syndrome, epidermolysis bullosa dystrophica, Fabry's disease, Fairbanks disease, Marfan syndrome, Myoadenylate deaminase deficiency,
Hematologic	Acute lymphoblastic leukemia, acute myeloid leukemia, anemia, chronic myelogenous leukemia, fungemia, hairy cell leukemia, hemochromatosis, hemolytic anemia, hereditary elliptocytosis, hereditary spherocytosis, leukemia, megaloblastic anemias, methemoglobinemia, polycythemia Vera, sickle-cell disease
Iatrogenic	Blood transfusion, radiation poisoning, short bowel syndrome
Infectious Disease	African Trypanosomiasis, AIDS, bacterial pneumonia, blastocystosis, botulism, coccidioidomycosis, dientamoebiasis, diphtheria, ebola hemorrhagic fever, entamoeba histolytica, enterovirus, Epstein-Barr virus, Hantavirus pulmonary syndrome, Helicobacter pylori infection, herpes simplex virus, HIV, hookworm, Infectious mononucleosis, Influenza, lassa fever, Lyme disease, Marburg hemorrhagic fever, mycobacterium avium complex infection, Neisseria meningitidis, post-polio syndrome, post-viral fatigue syndrome, rhinovirus, schistosomiasis, syphillis, tuberculosis, tularemia, viral Hemorrhagic Fever
Musculoskeletal / Ortho	Ankylosing spondylitis, Duchenne muscular dystrophy, Fairbanks disease, osteitis fibrosa cystica, osteomalacia, osteomyelitis, polymyalgia rheumatica, pregnancy, Still's disease
Neurologic	Arnold-Chiari malformation, benign fasciculation syndrome, bipolar disorder, brain abscess, chronic inflammatory demyelinating polyneuropathy, encephalomyelitis, migraine, multiple sclerosis, neuroglycopenia, neuromuscular weakness, Parkinson's disease, post-concussion syndrome,
Nutritional / Metabolic	B12 Deficiency, Gaucher's disease, low-carbohydrate diet, milk-alkali syndrome, mushroom poisoning, pernicious anemia, pyruvate carboxylase deficiency, vitamin C megadosage,
Obstetric/Gynecologic	Cervical cancer, endometriosis, gestational diabetes, ovarian cancer, ovarian cyst, perimenopause, Sheehan's Syndrome,
Oncologic	Adrenal metastases, cancer Syndrome, Hodgkin's lymphoma, mesothelioma, multiple endocrine neoplasia type 1, multiple endocrine neoplasia type 2, multiple myeloma, myelodysplastic Syndrome, myleofibrosis, neuroblastoma
Opthalmologic	Cogan syndrome, Tolosa-Hunt syndrome,
Overdose / Toxicity	Barbiturate, hydrogen sulfide, hypervitaminosis D, satratoxin-H
Psychiatric	Anorexia Nervosa, anxiety disorder, bulimia nervosa, clinical depression, conversion disorder, Da Costa's syndrome, diabulimia, major depression, postnatal depression, psychosomatic illness, sick building syndrome,Addiction
Pulmonary	Bronchitis, chronic obstructive pulmonary disease, emphysema, lower respiratory tract infection, lung cancer, pneumonia, pulmonary hypertension, respiratory acidosis, upper airway resistance syndrome (UARS)
Renal / Electrolyte	Azotemia, chronic kidney disease, chronic pyelonephritis, chronic renal failure, Gitelman syndrome, hemorrhagic fever with renal syndrome, hypercalcemia, hypocalcemia, hypokalemia, Interstitial nephritis, polycystic kidney disease, urinary tract infection
Rheum / Immune / Allergy	Evans syndrome, hay fever, Myasthenia gravis, panniculitis, phlegmon, polyarteritis nodosa, polymyositis, primary biliary cirrhosis, sarcoidosis, Sjogren's Syndrome, systemic lupus erythematosus, Takayasu's arteritis, Wegener's granulomatosis
Sexual	Acute prostatitis, andropause,
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	Adiposis dolorosa, airsickness, altitude sickness, chronic Fatigue Syndrome, chronic mountain sickness, decompression sickness, dehydration, exertion, fever, fibromyalgia, hangover, hyperglycemia, hypermobility, hypoglycemia, Kikuchi disease, motion sickness, myofascial pain syndrome, reactive hypoglycemia, sleep deprivation, sleep disorder, sleeping sickness, SSRI discontinuation syndrome

Causes in Alphabetical Order

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