Fatigue causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: M.Umer Tariq [2] Kiran Singh, M.D. [3]

Overview

Fatigue is a subjective feeling of tiredness with physical and mental causes. It can be a normal response to physical activity, emotional stress, boredom or lack of sleep. But fatigue can also be a sign of serious mental or physical condition if not relieved by enough sleep, good nutrition, or a low stress environment.

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Common Causes

• Allergic rhinitis
• Antidepressants
• Antihypertensives
• Anxiety
• Chronic fatigue syndrome
• Depression
• Hypnotics
• Hypothyroidism
• Malnutrition
• Occult malignancy
• Severe anemia

Causes by Organ System

Cardiovascular	Angina pectoris, atrial fibrillation, cardiac amyloidosis, cardiogenic shock, cerebrovascular arteriosclerosis, cholesterol pericarditis, congenital heart disease, congestive heart failure, constrictive pericarditis, coronary artery disease, coronary artery fistula, double outlet right ventricle, giant cell arteritis, hypertensive heart disease, hypertrophic cardiomyopathy, hypotension, inappropriate sinus tachycardia, infective endocarditis, mitral stenosis, mitral valve prolapse, myocardial infarction, pericardial constriction, postural orthostatic tachycardia syndrome, right ventricular outflow tract obstruction, sick sinus syndrome, subacute bacterial endocarditis, tricuspid regurgitation, trifascicular block, ventricular septal defect, Wolff-Parkinson-White syndrome, amyloidosis, aortic stenosis, asymmetric septal hypertrophy, atrial myxoma, familial, Austrian syndrome, bacterial endocarditis, Barth syndrome, calcium deficiency, cardiac malformation, cardiogenic shock, central sleep apnea, cerebrovascular arteriosclerosis, constrictive pericarditis, coronary artery disease, coronary artery fistula, decreased oxygen saturation, dilated cardiomyopathy, double outlet right ventricle, Dressler syndrome, Ebstein's anomaly, endocarditis, heart attack, heart block
Chemical / poisoning	1,3-Dichloropropene, amidithion, antifreeze, azinfosethyl, azinophos-methyl, azothoate, bifenthrin, bioallethrin, biphenyl, brodifacoum, bromadiolone, bromophos, cadmium, cadusafos, carbon monoxide poisoning, carbophenothion, chemical pneumonia, chlorfenvinphos, chlorinated naphthalene, chloromethane, chlorophacinone rodenticide poisoning, chloropyrifos, ciguatera, ciguatera, coumachlor rodenticide poisoning, coumafuryl rodenticide poisoning, coumatetralyl rodenticide poisoning, cyanthoate , cyclohexanone, cyclohexylamine, cyfluthrin, deltamethrin, demeton, difenacoum rodenticide poisoning, demeton-methyl, difethialone rodenticide poisoning, dimethoate, endothion, ethion, ethoate-methyl, ethoprophos, ethyl-guthion, ethylbenzene, ethylene, etrimfos, fenchlorphos, fenitrothion, fenthion, fenvalerate, finale rodenticide poisoning, flocoumafen rodenticide poisoning , folgorat rodenticide poisoning , fonophos, formothion, foxglove poisoning, guthion (ethyl), havoc rodenticide poisoning, heavy metal poisoning, lead, monocrotophos, naphthalene, silicosis
Dermatologic	Dermatomyositis , erysipelas, erythema chronicum migrans , essential thrombocytopenia, pityriasis rosea
Drug Side Effect	Acetaminophen, aciclovir, adderall, aldesleukin, alprazolam, altretamine, amikacin Sulfate Injection, amiloride and hydrochlorothiazide, amiton, amlodipine and benazepril, aprepitant, auranofin, azelastine, barbiturate, betablockers, bezafibrate, botulinum toxin, bromopride, busulfan, carboplatin, carfilzomib, carmustine, tenofovir disoproxil fumarate, carboplatin, caspofungin acetate, cerivastatin, chlorambucil, chloropyramine, citalopram, citrulline, cladribine, clobenzorex, clomipramine, clonidine, crizotinib, cyclobenzaprine, cytarabine , dacarbazine, dantrolene oral, daunorubicin, delavirdine, denileukin diftitox, depo-provera, desloratadine, desmopressin, dexedrine overdose , dextromethorphan hydrobromide, diborane, diflunisal, dobutamine hydrochloride Injection, docetaxel, doxepin, doxorubicin, duloxetine, ecallantide, efavirenz, emtricitabine, eliglustat, eslicarbazepine acetate, etoposide, exemestane, ezetimibe/simvastatin, febuxostat, fenofibrate, floxuridine, fluconazole Injection, eltrombopag, enzalutamide, eribulin, fludarabine phosphate, fluorouracil, gemcitabine Hydrochloride, gentamicin Sulfate Injection, grifulvin V, griseofulvin, guanfacine, antihistamine, histrelin, Ibrutinib, Idarubicin, Ifosfamide, Imiglucerase, Imiquimod, Indapamide, Interferon alfa-2a and alfa-2b Injection, Interferon alfa 2b, Interferon-gamma, Interferon Gamma-1b Injection, Ipilimumab, Itraconazole, Ivermectin, Ixabepilone, labetalol, lamivudine, lamotrigine, lapatinib, lenalidomide, letrozole, levetiracetam, levocetirizine, levonorgestrel, levothyroxine, leuprolide, lisinopril and hydrochlorothiazide, lorcaserin, lomustine, loperamide, loratadine, maprotiline, mechlorethamine, medroxyprogesterone, melatonin, meloxicam, mercaptopurine, meropenem Injection, mesna, methotrexate Injection, metoclopramide hydrochloride Injection, mifepristone, mitomycin, molybdenum, moxonidine, mycophenolic acid, nadolol, natalizumab, nebivolol, nitrazepam, oprelvekin, Oxaliplatin, Oxcarbazepine, Paclitaxel, Palbociclib, Panitumumab, Pantothenic acid, Pasireotide, pazopanib hydrochloride, Pegaspargase, pegylated interferon alfa-2a, pentamidine Inhalation, pentostatin, perampanel, perindopril, pertuzumab, phenelzine, pilocarpine, pirfenidone, plerixafor, plicamycin, praziquantel, procarbazine, progesterone, promethazine, potassium Iodide, quazepam, quinapril, quinidine oral, radafaxine, ramelteon, reserpine, rifabutin, rilmenidine,rilpivirine, ritonavir, rizatriptan, romiplostim, rufinamide, sargramostim Injection, sipuleucel-T, streptozocin, sumatriptan, sunitinib, temozolomide, teniposide, terazosin, thalidomide, thiabendazole, thiazide, thioguanine, thiotepa, tinidazole, tobramycin sulfate Injection, topiramate, topotecan hydrochloride, torsemide Injection, torsemide oral, tralomethrin, trametinib dimethyl sulfoxide, trandolapril, trastuzumab, trazodone, trepanation, trestolone, triazolam, trimetrexate glucuronate, trovafloxacin, valaciclovir, valproic Acid, venlafaxine, vandetanib, vicodin, vigabatrin, vinblastine, vinorelbine Tartrate, vorinostat, zalcitabine, zidovudine Injection, zileuton, zoledronate, zopiclone
Ear Nose Throat	Acute viral nasopharyngitis (common cold), sinusitis, Cogan syndrome, deafness , decompression sickness
Endocrine	Acromegaly , Addison's disease, adrenal cancer, adrenal crisis, adrenal gland hyperfunction, adrenal gland hypofunction, adrenal incidentaloma, adrenal insufficiency , adrenal metastases, adrenocortical insufficiency, amyloidosis, andropause, anorexia nervosa, calcium deficiency, conn's syndrome, cushing's Disease, Depo-Provera, diabetes insipidus, diabetes mellitus, emergency contraception, empty sella syndrome, glucocorticoid resistance, Graves' Disease, Hashimoto's thyroiditis, hyperparathyroidism, hyperthyroidism, hypogonadism, hypopituitarism, hypothyroidism
Environmental	No underlying causes
Gastroenterologic	Accessory pancreas, alpha 1-antitrypsin deficiency, anorexia nervosa, ascites, autoimmune hepatitis, Baber's syndrome, biliary cirrhosis, blastocystosis, brainerd diarrhea, carnitine palmitoyl transferase deficiency , celiac disease, cholestasis, cholestasis disease of pregnancy, chronic liver disease, chronic pancreatitis, cirrhosis, collagenous colitis, colorectal cancer, colorectal polyps, crohn's disease, diarrhea, dientamoebiasis, diverticular disease, duodenal ulcer, food allergy, gastric dumping syndrome, gastric lymphoma, gastric ulcer, gastrinoma, gastroenteritis, gastrointestinal bleeding, glycogen storage disease, hepatitis , hepatitis A, hepatitis C, Inflammatory bowel disease, Irritable bowel syndrome, pseudomembranous colitis, ulcerative colitis
Genetic	Adrenoleukodystrophy , Albright's hereditary osteodystrophy, alpha 1-antitrypsin deficiency, Bare lymphocyte syndrome , Barth syndrome, Becker's muscular dystrophy, calcification of basal ganglia, cancer syndrome, cardiac malformation, carnitine palmitoyl transferase deficiency , celiac disease, connective tissue disease, crohn's disease, Down's syndrome , Duchenne muscular dystrophy, Ehlers-Danlos syndrome,Engelmann syndrome, epidermolysis bullosa dystrophica, epiphyseal dysplasia, multiple, Fabry's disease, Fairbanks disease, Fanconi's anemia,Friedreich ataxia, glucose-6-phosphate dehydrogenase deficiency, Marfan syndrome, myoadenylate deaminase deficiency
Hematologic	Acute erythroleukemia, acute lymphoblastic leukemia, acute myeloid leukemia, anemia, angiofollicular ganglionic hyperplasia, aplastic anemia, autoimmune hemolytic anemia, B12 deficiency, blast crisis, blood transfusion, chloroma, chronic myelogenous leukemia, chronic neutrophilic leukemia, cyclic neutropenia, erythroblastopenia, essential thrombocytopenia, extramedullary myeloid tumor, Fanconi's anemia, glucose-6-phosphate dehydrogenase deficiency, hairy cell leukemia, hemochromatosis, hemolytic anemia, hemolytic uremic syndrome, hereditary elliptocytosis, hereditary spherocytosis, leukemia, megaloblastic anemia, methemoglobinemia, polycythemia vera, sickle-cell disease
Iatrogenic	Blood transfusion, radiation poisoning
Infectious Disease	Acute viral nasopharyngitis (common cold), African trypanosomiasis, AIDS, anthrax, arenavirus , babesiosis , bacterial endocarditis bacterial pneumonia, blastocystosis, blastomycosis, botulism, brain abscess, brucellosis, chemical pneumonia,cladosporium,coccidioidomycosis, Creutzfeldt-Jakob disease, croup, cyclosporiasis, cytomegalic inclusion body disease, cytomegalovirus, diarrhea, Dientamoebiasis, diphtheria, ebola hemorrhagic fever, encephalitis, encephalitis lethargica, endocarditis, entamoeba histolytica, enterovirus, Epstein-Barr virus, erythema chronicum migrans , flea-borne diseases, flu, food poisoning , Hantavirus pulmonary syndrome, Helicobacter pylori infection, helminthiasis , Hemophilus influenzae b, hepatitis, hepatitis A, hepatitis C, herpes simplex virus, HIV, hookworm, Infectious mononucleosis, Influenza, Kikuchi disease, lassa fever, Lyme disease, Marburg hemorrhagic fever, mycobacterium avium complex infection, Neisseria meningitidis,phlegmon, post-polio syndrome, post-viral fatigue syndrome, rhinovirus, schistosomiasis, syphillis, tuberculosis, tularemia, viral hemorrhagic Fever
Musculoskeletal / Ortho	Acrocephaly, ankylosing spondylitis, Barth syndrome, Becker's muscular dystrophy, Duchenne muscular dystrophy, Ehlers-Danlos syndrome, Engelmann syndrome, Fairbanks disease, osteitis fibrosa cystica, osteomalacia, osteomyelitis, polymyalgia rheumatica, Still's disease
Neurologic	Acute disseminated encephalomyelitis, African trypanosomiasis, aging brain syndrome, air embolism, airsickness, altitude sickness, alzheimer's disease, amyotrophic lateral sclerosis, Arnold-Chiari malformation, Austrian syndrome, autonomic dysfunction, B12 deficiency, benign fasciculation syndrome,Berry aneurysm,brain abscess, brain injury, brain tumor, brain stem glioma,botulism, calcification of basal ganglia,chronic fatigue immune dysfunction syndrome, chronic inflammatory demyelinating polyneuropathy, chronic mountain sickness, chronic wasting disease, chronic inflammatory demyelinating polyneuropathy, Creutzfeldt-Jakob disease, decompression sickness, dementia, Duchenne muscular dystrophy,encephalomyelitis,empty sella syndrome, encephalitis lethargica, encephalitis, encephalomyelitis, Friedreich ataxia, migraine, multiple sclerosis, neuroglycopenia, neuromuscular weakness, Parkinson's disease, post-concussion syndrome, Hemophilus influenzae b, motion sickness
Nutritional / Metabolic	B12 Deficiency, Gaucher's disease, low-carbohydrate diet, milk-alkali syndrome, mushroom poisoning, pernicious anemia, pyruvate carboxylase deficiency, short bowel syndrome, vitamin C megadosage, adrenoleukodystrophy, Albright's hereditary osteodystrophy, celiac disease, chronic vitamin A toxicity, dehydration, food poisoning, glycogen storage disease, hyperglycemia, hypoglycemia
Obstetric/Gynecologic	Cervical cancer, cholestasis disease of pregnancy , depo provera, eclampsia, emergency contraception, gestational diabetes, endometriosis, ovarian cancer, ovarian cyst, perimenopause, Sheehan's Syndrome
Oncologic	Adrenal metastases, acute erythroleukemia, acute lymphoblastic leukemia, acute myeloid leukemia, acute non lymphoblastic leukemia, adiposis dolorosa, adrenal cancer, adrenal incidentaloma, adrenal metastases, cancer Syndrome, angiosarcoma , Hodgkin's lymphoma, mesothelioma, multiple endocrine neoplasia type 1, multiple endocrine neoplasia type 2, multiple myeloma, myelodysplastic Syndrome, myleofibrosis, neuroblastoma
Opthalmologic	Cogan syndrome, Tolosa-Hunt syndrome
Overdose / Toxicity	Barbiturate, hydrogen sulfide, hypervitaminosis D, satratoxin-H
Psychiatric	Addiction , anorexia Nervosa, anxiety disorder, bulimia nervosa, conversion disorder, Da Costa's syndrome, diabulimia, dysthymia , emotional disorders , emotional exhaustion, excessive daytime sleepiness, excessive dieting , grief , major depression, postnatal depression, psychosomatic illness, sick building syndrome, sleep disorder
Pulmonary	Acute viral nasopharyngitis (common cold), acute bronchitis, air embolism, allergic rhinitis, alpha 1-antitrypsin deficiency, altitude sickness, alveolitis, asthma, Austrian syndrome, bacterial pneumonia, bagassosis, bird flu, bronchiolitis, bronchiolitis obliterans , bronchitis, bronchogenic carcinoma, central sleep apnea, chemical pneumonia, chemical worker's lung, chronic berylliosis, chronic bronchitis, chronic mountain sickness, chronic obstructive pulmonary disease, chronic obstructive pulmonary disease, croup, decompression sickness, decreased oxygen saturation, emphysema, emphysema, exercise-induced asthma, exogenous lipoid pneumonia, fibrosing alveolitis, hemophilus influenzae b, hemosiderosis, lower respiratory tract infection, lung cancer, pneumonia, pulmonary hypertension, respiratory acidosis, upper airway resistance syndrome
Renal / Electrolyte	Analgesic nephropathy syndrome, azotemia, Baber's syndrome, Bright's disease, Burnett's milk drinker's syndrome, Calcium deficiency,chronic pyelonephritis, chronic renal failure, Cope's syndrome, dehydration, diabetes insipidus, dilutional hyponatremia, Gitelman syndrome, glomerulonephritis, Goodpasture syndrome, hemolytic uremic syndrome, hemorrhagic fever with renal syndrome, hypercalcemia, hypocalcemia, hypokalemia, Interstitial nephritis, polycystic kidney disease, urinary tract infection
Rheum / Immune / Allergy	AIDS, allergic rhinitis, amyloidosis, angiofollicular ganglionic hyperplasia, ankylosing spondylitis, autoimmune disease, autoimmune hemolytic anemia, autoimmune hepatitis, Bare lymphocyte syndrome, chronic fatigue immune dysfunction syndrome, chronic inflammatory demyelinating polyneuropathy, crohn's disease, dermatomyositis , eosinophilia-myalgia syndrome, Evans syndrome, Felty's syndrome, food allergy, Goodpasture syndrome, hay fever,myasthenia gravis, myofascial pain syndrome, panniculitis, polyarteritis nodosa, polymyositis, primary biliary cirrhosis, sarcoidosis, Sjogren's Syndrome, systemic lupus erythematosus, Takayasu's arteritis, Wegener's granulomatosis
Sexual	Acute prostatitis, andropause
Trauma	Brain injury
Urologic	Bladder cancer
Miscellaneous	Fever, hangover, hypermobility, sleep deprivation, SSRI discontinuation syndrome, chronic pain, deconditioning, glaze , heat exhaustion

Causes in Alphabetical Order

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