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*The association between lung cancer and smoking was not defined until the mid-20th century. The first reports between lung cancer and smoking were often confounded by gender, given that men were more likely to be smokers compared to women. | *The association between lung cancer and smoking was not defined until the mid-20th century. The first reports between lung cancer and smoking were often confounded by gender, given that men were more likely to be smokers compared to women. | ||
*The 1969 handbook Springer Handbook of Special Pathology is considered the landmark publication that highlighted the role of smoking in the development of lung cancer in over 25 pages.<ref name="pmid11606795">{{cite journal |author=Witschi H |title=A short history of lung cancer |journal=[[Toxicological Sciences : an Official Journal of the Society of Toxicology]] |volume=64 |issue=1 |pages=4–6 |year=2001 |month=November |pmid=11606795 |doi= |url=http://toxsci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=11606795 |accessdate=2011-12-09}}</ref> | *The 1969 handbook Springer Handbook of Special Pathology is considered the landmark publication that highlighted the role of smoking in the development of lung cancer in over 25 pages.<ref name="pmid11606795">{{cite journal |author=Witschi H |title=A short history of lung cancer |journal=[[Toxicological Sciences : an Official Journal of the Society of Toxicology]] |volume=64 |issue=1 |pages=4–6 |year=2001 |month=November |pmid=11606795 |doi= |url=http://toxsci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=11606795 |accessdate=2011-12-09}}</ref> | ||
*Although chemotherapy had always been regarded to be ineffective in the management of lung cancer, cisplatin-based chemotherapy emerged in the 1980s and demonstrated modest efficacy in the reduction of | *Although chemotherapy had always been regarded to be ineffective in the management of lung cancer, cisplatin-based chemotherapy emerged in the 1980s and demonstrated modest efficacy in the reduction of tumor-related symptoms and improvement of quality of life. | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 17:44, 19 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Assistant Editor(s)-In-Chief: Yazan Daaboul, M.D.
Overview
Prior to the introduction of cigarette smoking and industrial carcinogens, lung cancer was thought to be a rare disease. Of all tumors detected an autopsy, lung cancer accounted for only 1% of cancers in the 1800s[1]. The majority of cases of lung cancer were associated with occupational hazards due to radon exposure. The association between lung cancer and smoking was not defined until the mid-20th century.
Historical Perspective
- The majority of cases of lung cancer were associated with occupational hazards. Death among miners was reported to be caused by Bergkrankheit (mountain sickness).[1]
- In 1924, radon gas was first reported to be a prominent cause of lung cancer among miners.[1]
- The association between lung cancer and smoking was not defined until the mid-20th century. The first reports between lung cancer and smoking were often confounded by gender, given that men were more likely to be smokers compared to women.
- The 1969 handbook Springer Handbook of Special Pathology is considered the landmark publication that highlighted the role of smoking in the development of lung cancer in over 25 pages.[1]
- Although chemotherapy had always been regarded to be ineffective in the management of lung cancer, cisplatin-based chemotherapy emerged in the 1980s and demonstrated modest efficacy in the reduction of tumor-related symptoms and improvement of quality of life.
References
- ↑ 1.0 1.1 1.2 1.3 Witschi H (2001). "A short history of lung cancer". Toxicological Sciences : an Official Journal of the Society of Toxicology. 64 (1): 4–6. PMID 11606795. Retrieved 2011-12-09. Unknown parameter
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