Stomach cancer endoscopy and biopsy: Difference between revisions
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{{Stomach cancer}} | {{Stomach cancer}} | ||
{{CMG}}{{AE}}{{PSD}} | |||
==Overview== | |||
==Endoscopy and Biopsy== | |||
===Biopsy=== | |||
*Gastric [[adenocarcinoma]] is a malignant epithelial [[tumor]], originating from [[glandular]] epithelium of the [[gastric]] [[mucosa]]. It invades the [[gastric]] wall, infiltrating the [[muscularis mucosae]], the [[submucosa]] and hence the muscularis propria. Histologically, there are two major types of gastric cancer (Lauren classification): intestinal type and diffuse type. | |||
**Intestinal type adenocarcinoma: [[Tumor]] cells describe irregular tubular structures, harboring pluristratification, multiple lumens, and reduced stroma ("back to back" aspect). Often, it associates intestinal metaplasia in neighboring [[mucosa]]. Depending on glandular architecture, cellular pleomorphism and mucosecretion, [[adenocarcinoma]] may present 3 degrees of differentiation: well, moderate and poorly differentiated. | |||
**Diffuse type [[adenocarcinoma]] (mucinous, colloid): [[tumor]] cells are discohesive and secrete mucus which is delivered in the [[interstitium]] producing large pools of mucus/colloid (optically "empty" spaces). It is poorly differentiated. If the [[mucus]] remains inside the [[tumor]] cell, it pushes the [[nucleus]] at the periphery - "signet-ring cell". | |||
[[Image:Linitis plastica 2.jpg|thumb|center|200px|Endoscopic image of [[linitis plastica]], a type of stomach cancer where the entire [[stomach]] is invaded, leading to a leather bottle-like appearance.]] | [[Image:Linitis plastica 2.jpg|thumb|center|200px|Endoscopic image of [[linitis plastica]], a type of stomach cancer where the entire [[stomach]] is invaded, leading to a leather bottle-like appearance.]] | ||
Revision as of 15:04, 27 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Endoscopy and Biopsy
Biopsy
- Gastric adenocarcinoma is a malignant epithelial tumor, originating from glandular epithelium of the gastric mucosa. It invades the gastric wall, infiltrating the muscularis mucosae, the submucosa and hence the muscularis propria. Histologically, there are two major types of gastric cancer (Lauren classification): intestinal type and diffuse type.
- Intestinal type adenocarcinoma: Tumor cells describe irregular tubular structures, harboring pluristratification, multiple lumens, and reduced stroma ("back to back" aspect). Often, it associates intestinal metaplasia in neighboring mucosa. Depending on glandular architecture, cellular pleomorphism and mucosecretion, adenocarcinoma may present 3 degrees of differentiation: well, moderate and poorly differentiated.
- Diffuse type adenocarcinoma (mucinous, colloid): tumor cells are discohesive and secrete mucus which is delivered in the interstitium producing large pools of mucus/colloid (optically "empty" spaces). It is poorly differentiated. If the mucus remains inside the tumor cell, it pushes the nucleus at the periphery - "signet-ring cell".
