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==Differentiating Hemophilia with other Diseases==
==Differentiating Hemophilia with other Diseases==
Hemophilia A can be mimicked by [[von Willebrand Disease]]
**[[von Willebrand Disease]]
Additionally, severe cases of [[vitamin K deficiency]] can present similar symptoms to hemophilia. This is because vitamin K is necessary for the human body to produce several protein clotting factors. This vitamin deficiency is rare in adults and older children but is common in newborns. Infants are born with naturally low levels of vitamin K and do not yet have the symbiotic gut flora to properly synthesise their own vitamin K. Bleeding issues due to vitamin K deficiency in infants is known as "haemorrhagic disease of the newborn", to avoid this complication newborns are routinely injected with vitamin K supplements.<ref>{{Cite web | title = Hemophilia Differential diagnosis| url =https://en.wikipedia.org/wiki/Haemophilia }}</ref>
**[[vitamin K deficiency]] or [[Warfarin]]
*The other conditions to be considered includes the following:
**Lupus Anticoagulant
**Lupus Anticoagulant
**Heparin Administration
**Heparin Administration
**[[Disseminated Intravascular Coagulation]]
**[[Disseminated Intravascular Coagulation]]
**Dysfibrinogenemia
**Dysfibrinogenemia
{| style="border: 0px; font-size: 90%; margin: 3px; width: 500px;" align=center
**Thrombocytopenia
|valign=top|
**Early liver failure
|+
**End-staged liver failure
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Condition}}
**[[Uremia]]
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Prothrombin time}}
**Congenital afibrinogenemia
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Partial Thromboplastin Time}}
**[[Factor V]] deficiency
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Bleeding Time}}
**Amyloid purpura
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Platelet Count}}
**Glanzmann's thrombasthenia
|-
**Bernard-soulier syndrome
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Hemophilia A or B
**[[Factor XII]] deficiency
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
**C1INH deficiency<ref>{{Cite web | title = Hemophilia Differential diagnosis| url =https://en.wikipedia.org/wiki/Haemophilia }}</ref>
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
 
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Von Willebrand Disease
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged or Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Thrombocytopenia
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Decreased
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Vitamin K deficiency or Warfarin
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Normal or mildly prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Disseminated Intravascular Coagulation
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Decreased
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Liver failure, early
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Aspirin
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Liver failure, end-stage
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Pronlonged
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Decreased
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Uremia
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Congenital afibrinogenemia
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Factor V deficiency
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Factor X deficiency as seen in amyloid purpura
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Glanzmann's thrombasthenia
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Bernard-Soulier syndrome
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Decreased
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Factor XII deficiency
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Prolonged
| style="padding: 5px 5px; background: #F5F5F5;" |Decreased or unaffected
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | C1INH deficiency
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Shortened
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
| style="padding: 5px 5px; background: #F5F5F5;" |Unaffected
|-
| style="padding: 5px 5px; background: #F5F5F5;" colspan=5| <small>Adapted from Wikipedia hemophilia Laboratory Finding> {{cite web| url=https://en.wikipedia.org/wiki/Haemophilia| title=Wikipedia Hemophilia Laboratory Finding  }}</small>
|}


==References==
==References==

Revision as of 21:33, 31 August 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Hemophilia must be differentiated from other diseases that lead to spontaneous bleeding and bleeding following injuries or surgery such as von Willebrand disease, liver failure-early or end stage, thrombocytopenia, vitamin K deficiency, disseminated intravascular coagulation, uremia, congenital afibrinogenemia, factor V deficiency, factor X deficiency as seen in amyloid purpura, glanzmann's thrombasthenia, bernard-soulier syndrome, factor XII deficiency and C1INH deficiency.

Differentiating Hemophilia with other Diseases

References

  1. ↑ "Hemophilia Differential diagnosis".

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