Hemophilia differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Hemophilia must be differentiated from other diseases that lead to spontaneous bleeding and bleeding following injuries or surgery such as von Willebrand disease, liver failure-early or end staged, thrombocytopenia, vitamin K deficiency, disseminated intravascular coagulation, uremia, congenital afibrinogenemia, factor V deficiency, factor X deficiency as seen in amyloid purpura, glanzmann's thrombasthenia, bernard-soulier syndrome, factor XII deficiency and C1INH deficiency.

Differentiating Hemophilia with other Diseases

• Von Willebrand Disease
• Vitamin K deficiency or Warfarin
• Lupus Anticoagulant

• Heparin Administration
  • Disseminated Intravascular Coagulation
  • Dysfibrinogenemia
  • Thrombocytopenia
  • Early liver failure
  • End-staged liver failure
  • Uremia
  • Congenital afibrinogenemia
  • Factor V deficiency
  • Amyloid purpura
  • Glanzmann's thrombasthenia
  • Bernard-soulier syndrome
  • Factor XII deficiency
  • C1INH deficiency