Prolactinoma causes: Difference between revisions
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=== Other Causes === | === Other Causes === | ||
The majority of moderately raised prolactin levels (up to 5000mIU/L) are not due to microprolactinomas but other causes. The effects of some prescription drugs are the most common, but the normal physiological causes of [[pregnancy]] & breastfeeding should not be forgotten, nor the effects of other pituitary [[tumors]]. This is discussed more under [[Hyperprolactinaemia]]. | The majority of moderately raised prolactin levels (up to 5000mIU/L) are not due to microprolactinomas but other causes. The effects of some prescription drugs are the most common, but the normal physiological causes of [[pregnancy]] & breastfeeding should not be forgotten, nor the effects of other pituitary [[tumors]]. This is discussed more under [[Hyperprolactinaemia]]. | ||
Drug Side Effect - [[Clomifene]] | Drug Side Effect - [[Clomifene]]. | ||
The xenoestrogenic chemical Bisphenol-A has been shown to lead to hyperprolactinaemia and growth of prolactin-producing pituitary cells<ref>^ Goloubkova T, Ribeiro MF, Rodrigues LP, Cecconello AL, Spritzer PM (April 2000). "Effects of xenoestrogen bisphenol A on uterine and pituitary weight, serum prolactin levels and immunoreactive prolactin cells in ovariectomized Wistar rats". Arch. Toxicol. 74 (2): 92–8. doi:10.1007/s002040050658. PMID 10839476</ref>. The increasing and prolonged exposure of Bisphenol-A from childhood on, may contribute to the growth of a prolactinoma. | The xenoestrogenic chemical Bisphenol-A has been shown to lead to hyperprolactinaemia and growth of prolactin-producing pituitary cells<ref>^ Goloubkova T, Ribeiro MF, Rodrigues LP, Cecconello AL, Spritzer PM (April 2000). "Effects of xenoestrogen bisphenol A on uterine and pituitary weight, serum prolactin levels and immunoreactive prolactin cells in ovariectomized Wistar rats". Arch. Toxicol. 74 (2): 92–8. doi:10.1007/s002040050658. PMID 10839476</ref>. The increasing and prolonged exposure of Bisphenol-A from childhood on, may contribute to the growth of a prolactinoma. | ||
== References == | == References == | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 20:53, 3 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]
Overview
It has been shown that stress can significantly raise prolactin levels which should make stress a diagnostic differential though it usually is not considered such. Most pituitary tumors are sporadic--they are not genetically passed from parents to offspring.
Causes
Although research continues to unravel the mysteries of disordered cell growth, the cause of pituitary tumors remains unknown. It has been shown that stress can significantly raise prolactin levels which should make stress a diagnostic differential though it usually is not considered such. Most pituitary tumors are sporadic--they are not genetically passed from parents to offspring.
Other Causes
The majority of moderately raised prolactin levels (up to 5000mIU/L) are not due to microprolactinomas but other causes. The effects of some prescription drugs are the most common, but the normal physiological causes of pregnancy & breastfeeding should not be forgotten, nor the effects of other pituitary tumors. This is discussed more under Hyperprolactinaemia. Drug Side Effect - Clomifene. The xenoestrogenic chemical Bisphenol-A has been shown to lead to hyperprolactinaemia and growth of prolactin-producing pituitary cells[1]. The increasing and prolonged exposure of Bisphenol-A from childhood on, may contribute to the growth of a prolactinoma.
References
- ↑ ^ Goloubkova T, Ribeiro MF, Rodrigues LP, Cecconello AL, Spritzer PM (April 2000). "Effects of xenoestrogen bisphenol A on uterine and pituitary weight, serum prolactin levels and immunoreactive prolactin cells in ovariectomized Wistar rats". Arch. Toxicol. 74 (2): 92–8. doi:10.1007/s002040050658. PMID 10839476