Prolactinoma causes: Difference between revisions
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==Causes== | ==Causes== | ||
There are no established causes for prolactinoma, although research continues to unravel the mysteries of disordered cell growth, the cause of [[pituitary]] tumors remains unknown. It has been shown that stress can significantly raise [[prolactin]] levels which should make stress a [[diagnostic]] differential though it usually is not considered such. Most pituitary tumors are sporadic--they are not genetically passed from parents to offspring. A minority of prolactinomas | There are no established causes for prolactinoma, although research continues to unravel the mysteries of disordered cell growth, the cause of [[pituitary]] tumors remains unknown. It has been shown that stress can significantly raise [[prolactin]] levels which should make stress a [[diagnostic]] differential though it usually is not considered such. Most pituitary tumors are sporadic--they are not genetically passed from parents to offspring. A minority of prolactinomas are associated with familial syndromes. | ||
===Familial Causes=== | ===Familial Causes=== | ||
[[Prolactinoma]] may occur as part of a hereditary disorder called multiple endocrine neoplasia type 1 (MEN 1). A minority of prolactinomas are associated with: | [[Prolactinoma]] may occur as part of a hereditary disorder called multiple endocrine neoplasia type 1 (MEN 1). A minority of prolactinomas are associated with: | ||
*Multiple endocrine neoplasia type I (MEN I) | *[[Multiple endocrine neoplasia type I]] (MEN I) | ||
*Carney complex | *Carney complex | ||
*McCune-Albright Syndrome | *McCune-Albright Syndrome | ||
Revision as of 13:42, 10 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]
Overview
There are no established causes for prolactinoma. Most pituitary tumors are sporadic--they are not genetically passed from parents to offspring.
Causes
There are no established causes for prolactinoma, although research continues to unravel the mysteries of disordered cell growth, the cause of pituitary tumors remains unknown. It has been shown that stress can significantly raise prolactin levels which should make stress a diagnostic differential though it usually is not considered such. Most pituitary tumors are sporadic--they are not genetically passed from parents to offspring. A minority of prolactinomas are associated with familial syndromes.
Familial Causes
Prolactinoma may occur as part of a hereditary disorder called multiple endocrine neoplasia type 1 (MEN 1). A minority of prolactinomas are associated with:
- Multiple endocrine neoplasia type I (MEN I)
- Carney complex
- McCune-Albright Syndrome
- MEN like syndrome ( CKDN1B loss of function)[1]
Other Causes
Other causes include:
- The xenoestrogenic chemical Bisphenol-A has been shown to lead to hyperprolactinaemia and growth of prolactin-producing pituitary cells.[2] The increasing and prolonged exposure of Bisphenol-A from childhood on, may contribute to the growth of a prolactinoma.
References
- ↑ http://radiopaedia.org/articles/pituitary-adenoma
- ↑ ^ Goloubkova T, Ribeiro MF, Rodrigues LP, Cecconello AL, Spritzer PM (April 2000). "Effects of xenoestrogen bisphenol A on uterine and pituitary weight, serum prolactin levels and immunoreactive prolactin cells in ovariectomized Wistar rats". Arch. Toxicol. 74 (2): 92–8. doi:10.1007/s002040050658. PMID 10839476