Prolactinoma pathophysiology: Difference between revisions
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==Associated Diseases== | ==Associated Diseases== | ||
Revision as of 15:52, 11 September 2015
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Prolactinoma Microchapters |
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Treatment |
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Prolactinoma pathophysiology On the Web |
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Risk calculators and risk factors for Prolactinoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]
Overview
Prolactinoma may occur as part of a hereditary disorder called multiple endocrine neoplasia type 1 (MEN 1). A minority of prolactinomas are associated with Carney complex, McCune-Albright Syndrome, MEN like syndrome (CKDN1B loss of function).[1]
Pathophysiology
Microscopic Pathology
Features of prolactinoma include:[2]
- Loss of fibrous stroma
- Normal (anterior) pituitary cells are nested
Notes:
- Smears very well
Stains
- Reticulin - loss of reticulin between tumor cells
Associated Diseases
Prolactinoma may occur as part of a hereditary disorder called multiple endocrine neoplasia type 1 (MEN 1). A minority of prolactinomas are associated with:[3][4]
- Multiple endocrine neoplasia type I (MEN I)
- Carney complex
- McCune-Albright Syndrome
- MEN like syndrome (CKDN1B loss of function)
Familial pituitary adenomas
A pituitary adenoma may be part of a familial syndrome:[5][6]
| Syndrome | Gene | Notes |
|---|---|---|
| Multiple endocrine neoplasia I | MEN1 | characterized by the 3 Ps: '''p'''ituitary adenoma, parathyroid adenoma, pancreatic neuroendocrine tumor |
| MEN-1-like syndrome | CDKN1B[7] | also known as Multiple endocrine neoplasia IV[7] |
| Carney syndrome | PRKAR1A | other findings (mnemonic NAME): nevi, atrial myxoma, myxoid neurofibroma, ephelides (freckles) |
| Isolated pituitary adenoma[8] | AIP | classically growth hormone-producing adenoma - leads to acromegaly |
References
- ↑ http://radiopaedia.org/articles/pituitary-adenoma
- ↑ Template:Ref PSNP
- ↑ http://radiopaedia.org/articles/pituitary-adenoma
- ↑ http://radiopaedia.org/articles/pituitary-adenoma
- ↑ Elston, MS.; McDonald, KL.; Clifton-Bligh, RJ.; Robinson, BG. (2009). "Familial pituitary tumor syndromes". Nat Rev Endocrinol. 5 (8): 453–61. doi:10.1038/nrendo.2009.126. PMID 19564887. Unknown parameter
|month=ignored (help) - ↑ Template:Ref PCPBoD8
- ↑ 7.0 7.1 Online Mendelian Inheritance in Man (OMIM) 600778
- ↑ Korbonits, M.; Storr, H.; Kumar, AV. (2012). "Familial pituitary adenomas - Who should be tested for AIP mutations?". Clin Endocrinol (Oxf). doi:10.1111/j.1365-2265.2012.04445.x. PMID 22612670. Unknown parameter
|month=ignored (help)