Glioblastoma multiforme pathophysiology: Difference between revisions

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Revision as of 17:55, 12 September 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Development of glioblastoma is the result from multiple genetic mutations.
Genes involved in the pathogenesis of glioblastoma include:^[1]
- EGFR
- MDM2
- PTEN
- Chromosome 10p

Glioblastoma may be associated with:^[1]

↑ ^1.0 ^1.1 Pathology of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma

@@ Line 7: / Line 7: @@
 ==Pathophysiology==
 ===Genetics===
-* Almost all cases of GBM are sporadic, without a familial predilection, although [[chromosome|chromosomal]] aberrations such as [[PTEN (gene)|PTEN]] mutation, and [[p53]] mutation are commonly seen in these tumors.
+*Development of glioblastoma is the result from multiple genetic mutations.
-* Growth factor aberrant signaling associated with [[Epidermal_growth_factor_receptor|EGFR]], and [[PDGF]] are also seen.
+*Genes involved in the pathogenesis of glioblastoma include:<ref name=ddd>Pathology of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref>
+**''EGFR''
+**''MDM2''
+**''PTEN''
+**Chromosome 10p
 ===Associated Conditions===