Glioblastoma multiforme pathophysiology: Difference between revisions
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===Genetics=== | ===Genetics=== | ||
*Development of glioblastoma is the result from multiple genetic mutations. | *Development of glioblastoma is the result from multiple genetic mutations. | ||
*Genes involved in the pathogenesis of glioblastoma include:<ref name=ddd>Pathology of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref> | *Genes involved in the pathogenesis of primary glioblastoma include:<ref name=ddd>Pathology of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref> | ||
**''[[Mdm2]]'' | **''[[Mdm2]]'' | ||
**''[[PTEN]]'' | **''[[PTEN]]'' | ||
**Chromosome 10p | **Chromosome 10p | ||
*Genes involved in the pathogenesis of secondary glioblastoma include:<ref name=ddd>Pathology of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref> | |||
**''IDH1'' | |||
**''p53'' | |||
**Chromosomes 10q, 17p, and 19q | |||
===Associated Conditions=== | ===Associated Conditions=== | ||
Revision as of 22:14, 12 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Genetics
- Development of glioblastoma is the result from multiple genetic mutations.
- Genes involved in the pathogenesis of primary glioblastoma include:[1]
- Genes involved in the pathogenesis of secondary glioblastoma include:[1]
- IDH1
- p53
- Chromosomes 10q, 17p, and 19q
Associated Conditions
Glioblastoma may be associated with:[1]
- Neurofibromatosis type 1
- Li-Fraumeni syndrome
- Turcot syndrome
- Ollier disease
- Maffucci syndrome
Gross Pathology
Microscopic Pathology
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Glioblastoma (histology slide)
.jpg)
References
- ↑ 1.0 1.1 1.2 Pathology of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma