Glioblastoma multiforme pathophysiology: Difference between revisions
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===Gross Pathology=== | ===Gross Pathology=== | ||
On gross pathology, the characteristic findings of glioblastomas include:<ref name=ccc>xyz of glioblastoma multiforme. Libre Pathology. http://librepathology.org/wiki/index.php/Glioblastoma</ref><ref name=ddd>XYZ of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref> | On gross pathology, the characteristic findings of glioblastomas include:<ref name=ccc>xyz of glioblastoma multiforme. Libre Pathology. http://librepathology.org/wiki/index.php/Glioblastoma</ref><ref name=ddd>XYZ of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref> | ||
*[[Supratentorial white matter]] is the most common location | *[[Supratentorial]] [[white matter]] is the most common location | ||
*Poorly-marginated, diffusely infiltrating necrotic mass localized to the [[cerebral hemisphere]] | *Poorly-marginated, diffusely infiltrating necrotic mass localized to the [[cerebral hemisphere]] | ||
*Ill-defined borders | *Ill-defined borders | ||
Revision as of 23:11, 12 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Genetics
- Development of glioblastoma is the result from multiple genetic mutations.
- Genes involved in the pathogenesis of primary glioblastoma include:[1]
- Genes involved in the pathogenesis of secondary glioblastoma include:[1]
- IDH1
- p53
- Chromosome 10q
- Chromosome 17p
- Chromosome 19q
Associated Conditions
Glioblastoma may be associated with:[1]
- Neurofibromatosis type 1
- Li-Fraumeni syndrome
- Turcot syndrome
- Ollier disease
- Maffucci syndrome
- Tuberous sclerosis
- Von Hippel-Lindau disease
Gross Pathology
On gross pathology, the characteristic findings of glioblastomas include:[2][1]
- Supratentorial white matter is the most common location
- Poorly-marginated, diffusely infiltrating necrotic mass localized to the cerebral hemisphere
- Ill-defined borders
- Tumor may be firm or gelatinous
- Variable appearance (firm and white, to soft and yellow, to cystic with hemorrhage)
- Midline shift due to tumor mass
- Presents as bihemispheric "butterfly glioma" in the corpus callosum
Microscopic Pathology
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Glioblastoma (histology slide)
.jpg)
References
- ↑ 1.0 1.1 1.2 1.3 Pathology of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma
- ↑ xyz of glioblastoma multiforme. Libre Pathology. http://librepathology.org/wiki/index.php/Glioblastoma