Glioblastoma multiforme pathophysiology: Difference between revisions
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===Genetics=== | ===Genetics=== | ||
*Development of glioblastoma is the result from multiple genetic mutations. | *Development of glioblastoma is the result from multiple genetic mutations. | ||
*Genes involved in the pathogenesis of | *Genes involved in the pathogenesis of glioblastoma include:<ref name=ddd>Pathology of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref> | ||
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**''IDH1'' | |valign=top| | ||
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! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Type of glioblastoma}} | |||
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Genes}} | |||
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:Primary | |||
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*''[[Mdm2]]'' | |||
*''[[PTEN]]'' | |||
*Chromosome 10p | |||
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:Secondary | |||
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*''IDH1'' | |||
*''[[p53]]'' | |||
*Chromosome 10q | |||
*Chromosome 17p | |||
*Chromosome 19q | |||
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===Associated Conditions=== | ===Associated Conditions=== | ||
Revision as of 00:08, 13 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Genetics
- Development of glioblastoma is the result from multiple genetic mutations.
- Genes involved in the pathogenesis of glioblastoma include:[1]
| Type of glioblastoma | Genes |
|---|---|
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Associated Conditions
Glioblastoma may be associated with:[1]
- Neurofibromatosis type 1
- Li-Fraumeni syndrome
- Turcot syndrome
- Ollier disease
- Maffucci syndrome
- Tuberous sclerosis
- Von Hippel-Lindau disease
Gross Pathology
On gross pathology, the characteristic findings of glioblastomas include:[1][2]
- Supratentorial white matter is the most common location
- Poorly-marginated, diffusely infiltrating mass with central necrotic core
- Ill-defined borders
- Firm or gelatinous in consistency
- Variable appearance (firm and white, to soft and yellow, to cystic with hemorrhage)
- Midline shift due to tumor mass
- Bihemispheric "butterfly glioma" in the corpus callosum
Microscopic Pathology
On microscopic histopathological analysis, the characteristic findings of glioblastomas include:[1][2]
- Pleomorphic astrocytes with marked atypia and mitosis
- Necrosis and microvascular proliferation
- (+/-) Pseudopalisading necrosis
- Tumor cells lined-up like a picket fence around necrotic areas
Markers
Glioblastoma is demonstrated by positivity to tumor marker such as GFAP.[1]
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Glioblastoma (histology slide)
.jpg)
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Pathology of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma
- ↑ 2.0 2.1 Pathology of glioblastoma multiforme. Libre Pathology. http://librepathology.org/wiki/index.php/Glioblastoma