Prolactinoma medical therapy: Difference between revisions
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{{CMG}} {{AE}}{{Faizan}} | {{CMG}} {{AE}}{{Faizan}} | ||
==Overview== | ==Overview== | ||
Medical therapy for prolactinoma includes [[dopamine agonists]]. The goal of treatment is to return [[prolactin]] secretion to normal, reduce [[tumor]] size, correct any [[visual]] abnormalities and restore normal [[pituitary]] function. | Medical therapy for prolactinoma includes [[dopamine agonists]] (either [[Cabergoline]] or [[Bromocriptine]]). The goal of treatment is to return [[prolactin]] secretion to normal, reduce [[tumor]] size, correct any [[visual]] abnormalities and restore normal [[pituitary]] function. | ||
==Medical Therapy== | ==Medical Therapy== | ||
Medical therapy for prolactinoma includes [[dopamine]] agonists ([[bromocriptine]] or [[cabergoline]]). | Medical therapy for prolactinoma includes [[dopamine]] agonists ([[bromocriptine]] or [[cabergoline]]). | ||
* [[ | * Preferred regimen: [[Cabergoline]]: 0.25 mg PO twice weekly | ||
:* The dose | :* The dose may be gradually increased every 4 weeks as needed, up to 1 mg twice weekly. | ||
* [[ | * Alternative regimen: [[Bromocriptine]]: 25 mg PO once daily for 1 week | ||
:* The dose may be increased every | :* The dose may be gradually increased every 3 to 7 days as needed. | ||
These [[drug]]s | |||
These [[drug]]s reduce the [[tumor]] size and return [[prolactin]] concentration to normal in approximately 80% of patients. Both drugs have been approved by the U.S Food and Drug Administration for the treatment of hyperprolactinemia. | |||
==Radiation Therapy== | ==Radiation Therapy== | ||
Rarely, [[radiation therapy]] is used if | Rarely, [[radiation therapy]] is used if medical therapy and [[surgery]] fail to reduce [[prolactin]] concentration. Depending on the size and location of the [[tumor]], [[radiation]] is delivered either in low doses over the course of 5 to 6 weeks or in a single high dose. [[Radiation]] therapy is effective in approximately 30% of cases. | ||
== References == | == References == | ||
Revision as of 17:17, 15 September 2015
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Prolactinoma Microchapters |
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Prolactinoma medical therapy On the Web |
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Risk calculators and risk factors for Prolactinoma medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]
Overview
Medical therapy for prolactinoma includes dopamine agonists (either Cabergoline or Bromocriptine). The goal of treatment is to return prolactin secretion to normal, reduce tumor size, correct any visual abnormalities and restore normal pituitary function.
Medical Therapy
Medical therapy for prolactinoma includes dopamine agonists (bromocriptine or cabergoline).
- Preferred regimen: Cabergoline: 0.25 mg PO twice weekly
- The dose may be gradually increased every 4 weeks as needed, up to 1 mg twice weekly.
- Alternative regimen: Bromocriptine: 25 mg PO once daily for 1 week
- The dose may be gradually increased every 3 to 7 days as needed.
These drugs reduce the tumor size and return prolactin concentration to normal in approximately 80% of patients. Both drugs have been approved by the U.S Food and Drug Administration for the treatment of hyperprolactinemia.
Radiation Therapy
Rarely, radiation therapy is used if medical therapy and surgery fail to reduce prolactin concentration. Depending on the size and location of the tumor, radiation is delivered either in low doses over the course of 5 to 6 weeks or in a single high dose. Radiation therapy is effective in approximately 30% of cases.