Glioblastoma multiforme medical therapy: Difference between revisions
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Supportive therapy for glioblastoma includes [[anticonvulsants]] and [[corticosteroids]], which focuses on relieving symptoms and improving the patient’s neurologic function. | Supportive therapy for glioblastoma includes [[anticonvulsants]] and [[corticosteroids]], which focuses on relieving symptoms and improving the patient’s neurologic function. | ||
*[[Anticonvulsants]] are administered to the patients who have a [[seizure]]. [[Phenytoin]] given concurrently with [[radiation]] may have serious skin reactions such as [[erythema multiforme]] and [[Stevens-Johnson syndrome]]. | *[[Anticonvulsants]] are administered to the patients who have a [[seizure]]. [[Phenytoin]] given concurrently with [[radiation]] may have serious skin reactions such as [[erythema multiforme]] and [[Stevens-Johnson syndrome]]. | ||
*[[Corticosteroids]], usually [[dexamethasone]] given 4-10 mg every 4-6 h, can reduce peritumoral [[edema]], diminish mass effect, and lower [[intracranial pressure]] with a decrease in [[headache]] or [[drowsiness]]. | *[[Corticosteroids]], usually [[dexamethasone]] given 4-10 mg every 4-6 h, can reduce peritumoral [[edema]], diminish mass effect, and lower [[intracranial pressure]] with a decrease in [[headache]] or [[drowsiness]]. | ||
Revision as of 19:48, 15 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The predominant therapy for glioblastoma is surgical resection. Adjunctive chemotherapy and radiation may be required.[1] Supportive therapy for glioblastoma includes anticonvulsants and corticosteroids.
Medical Therapy
The predominant therapy for glioblastoma is surgical resection. Adjunctive chemotherapy and radiation may be required.[1]
Supportive treatment
Supportive therapy for glioblastoma includes anticonvulsants and corticosteroids, which focuses on relieving symptoms and improving the patient’s neurologic function.
- Anticonvulsants are administered to the patients who have a seizure. Phenytoin given concurrently with radiation may have serious skin reactions such as erythema multiforme and Stevens-Johnson syndrome.
- Corticosteroids, usually dexamethasone given 4-10 mg every 4-6 h, can reduce peritumoral edema, diminish mass effect, and lower intracranial pressure with a decrease in headache or drowsiness.
Radiotherapy
- After surgery, radiotherapy is recommended among all patients who develop glioblastoma.
- On an average, radiotherapy, after surgery, can reduce the tumor size to 107 cells.
- Targeted three-dimensional conformal radiotherapy is preferred to whole brain radiotherapy.
- Total radiation dose of 60–65 Gy has been found to be optimal for treatment.
References
- ↑ 1.0 1.1 Treatment of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma