Nasopharyngeal carcinoma pathophysiology: Difference between revisions
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**Cohesive cells with: | **Cohesive cells with: | ||
***Abundant dense eosinophilic cytoplasm. | ***Abundant dense eosinophilic cytoplasm. | ||
***Central nuclei +/- small/indistinct nucleoli. | ***Central nuclei +/- small/indistinct nucleoli.[[Image:Lymphoepithelioma_met_to_LN_6.jpg |thumb|none|250px| Nasopharyngeal carcinoma]] | ||
Image:Lymphoepithelioma_met_to_LN_6.jpg | Nasopharyngeal carcinoma | |||
===Histologic subclassification=== | ===Histologic subclassification=== | ||
World Health Classification (2005) for NPC:<ref name= Librepathology>Nasopharyngeal carcinoma http://librepathology.org/wiki/index.php/Nasopharyngeal_carcinoma</ref> | World Health Classification (2005) for NPC:<ref name= Librepathology>Nasopharyngeal carcinoma http://librepathology.org/wiki/index.php/Nasopharyngeal_carcinoma</ref> | ||
| Line 26: | Line 23: | ||
|- | |- | ||
| 1 | | 1 | ||
| | | Keratinizing SCC | ||
| graded poorly-well-diff. | | graded poorly-well-diff. | ||
| -ve | | -ve | ||
| | | | ||
| bad | | bad | ||
|- | |- | ||
| 2a | | 2a | ||
| | | Nonkeratinizing carcinoma, differentiated | ||
| well def. cell borders & tumour nest borders, mimics appearance of UCC | | well def. cell borders & tumour nest borders, mimics appearance of UCC | ||
| +ve | | +ve | ||
| | | | ||
| good | | good | ||
|- | |- | ||
| 2b | | 2b | ||
| | | Nonkeratinizing carcinoma, undifferentiated | ||
| sheets/syncytial, vescicular nuclei, prominent nucleoli, pink cytoplasm | | sheets/syncytial, vescicular nuclei, prominent nucleoli, pink cytoplasm | ||
| | | | ||
| most common | | most common | ||
| | | | ||
|- | |- | ||
| 3 | | 3 | ||
| | | Basaloid SCC | ||
| mimics BCC - see basaloid SCC | | mimics BCC - see basaloid SCC | ||
| | | | ||
| least common | | least common | ||
| | | | ||
|} | |} | ||
==Immunohistochemistry== | ==Immunohistochemistry== | ||
Revision as of 15:06, 16 September 2015
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Nasopharyngeal carcinoma Microchapters |
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Differentiating Nasopharyngeal carcinoma from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Nasopharyngeal carcinoma pathophysiology On the Web |
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American Roentgen Ray Society Images of Nasopharyngeal carcinoma pathophysiology |
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Risk calculators and risk factors for Nasopharyngeal carcinoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]
Pathophysiology
Gross
- Nasal cavity involvement - common in early disease.[1]
Microscopic
Features:[2]
- Prominent lymphoid component - key feature.
- Features of squamous cell carcinoma:
- Cohesive cells with:
- Abundant dense eosinophilic cytoplasm.
- Central nuclei +/- small/indistinct nucleoli.
Nasopharyngeal carcinoma
- Cohesive cells with:
Histologic subclassification
World Health Classification (2005) for NPC:[2]
| Type | Histology | Description | EBV | Prevalence | Prognosis |
|---|---|---|---|---|---|
| 1 | Keratinizing SCC | graded poorly-well-diff. | -ve | bad | |
| 2a | Nonkeratinizing carcinoma, differentiated | well def. cell borders & tumour nest borders, mimics appearance of UCC | +ve | good | |
| 2b | Nonkeratinizing carcinoma, undifferentiated | sheets/syncytial, vescicular nuclei, prominent nucleoli, pink cytoplasm | most common | ||
| 3 | Basaloid SCC | mimics BCC - see basaloid SCC | least common |
Immunohistochemistry
- EBER +ve.
- p16 -ve.[3]
References
- ↑ Abdel Khalek Abdel Razek, A.; King, A. (2012). "MRI and CT of nasopharyngeal carcinoma". AJR Am J Roentgenol. 198 (1): 11–8. doi:10.2214/AJR.11.6954. PMID 22194474. Unknown parameter
|month=ignored (help) - ↑ 2.0 2.1 Nasopharyngeal carcinoma http://librepathology.org/wiki/index.php/Nasopharyngeal_carcinoma
- ↑ Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY, Geradts J (1998). "Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product". Am. J. Pathol. 152 (4): 865–9. PMC 1858242. PMID 9546345. Unknown parameter
|month=ignored (help)