Glioblastoma multiforme classification: Difference between revisions
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==Classification== | ==Classification== | ||
Glioblastoma may be classified into two | Glioblastoma may be classified according to its origin into two subtypes: Primary and secondary.<ref name=ddd>Classification of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref> | ||
==== | ====Primary glioblastoma==== | ||
*De novo origin | *De novo origin | ||
*More aggressive | *More aggressive | ||
*Occurs in older patients | *Occurs in older patients | ||
==== | ====Secondary glioblastoma==== | ||
*Arises from pre-existing lower grade gliomas | *Arises from pre-existing lower grade gliomas | ||
*Less aggressive | *Less aggressive | ||
*Occurs in younger patients | *Occurs in younger patients | ||
Glioblastoma may be classified according to its molecular alterations into four subtypes: | |||
*Classic | |||
*Proneural | |||
*Mesenchymal | |||
*Neural | |||
==References== | ==References== | ||
Revision as of 16:10, 16 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Glioblastoma may be classified into several subtypes based on its origin and molecular alterations.[1] [2]
Classification
Glioblastoma may be classified according to its origin into two subtypes: Primary and secondary.[2]
Primary glioblastoma
- De novo origin
- More aggressive
- Occurs in older patients
Secondary glioblastoma
- Arises from pre-existing lower grade gliomas
- Less aggressive
- Occurs in younger patients
Glioblastoma may be classified according to its molecular alterations into four subtypes:
- Classic
- Proneural
- Mesenchymal
- Neural
References
- ↑ Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD; et al. (2010). "Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1". Cancer Cell. 17 (1): 98–110. doi:10.1016/j.ccr.2009.12.020. PMC 2818769. PMID 20129251.
- ↑ 2.0 2.1 Classification of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma