Glioblastoma multiforme surgery: Difference between revisions
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==Surgery== | ==Surgery== | ||
Surgery is the mainstay of treatment for glioblastoma.<ref name=ddd>Treatment of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref> | Surgery is the mainstay of treatment for glioblastoma.<ref name=ddd>Treatment of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref> | ||
*An average glioblastoma tumor contains 10<sup>11</sup> cells, which is | *An average glioblastoma tumor contains 10<sup>11</sup> cells, which is reduced to 10<sup>9</sup> cells after surgery (a reduction of 99%). | ||
*It is used to take a section for a pathological diagnosis, to remove some of the symptoms of a large mass pressing against the brain, to remove [[tumor]] before secondary resistance to [[radiotherapy]] and [[chemotherapy]], and to prolong survival. | |||
*Greater the extent of tumor removal, better the prognosis is. Removal of 98% or more of the tumor has been associated with a significantly longer healthier time. | |||
*The chances of near-complete initial removal of the tumor can be greatly increased if the surgery is guided by a fluorescent dye known as [[5-aminolevulinic acid]]. Glioblastoma tumor cells are widely infiltrative through the brain at diagnosis, and so despite a "total resection" of all obvious tumor, most people with glioblastoma later develop recurrent tumors either near the original site or at more distant "satellite lesions" within the brain. Other modalities, including radiation, are used after surgery in an effort to suppress and slow recurrent disease. | |||
==References== | ==References== | ||
Revision as of 18:26, 16 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Surgery is the mainstay of treatment for glioblastoma.[1]
Surgery
Surgery is the mainstay of treatment for glioblastoma.[1]
- An average glioblastoma tumor contains 1011 cells, which is reduced to 109 cells after surgery (a reduction of 99%).
- It is used to take a section for a pathological diagnosis, to remove some of the symptoms of a large mass pressing against the brain, to remove tumor before secondary resistance to radiotherapy and chemotherapy, and to prolong survival.
- Greater the extent of tumor removal, better the prognosis is. Removal of 98% or more of the tumor has been associated with a significantly longer healthier time.
- The chances of near-complete initial removal of the tumor can be greatly increased if the surgery is guided by a fluorescent dye known as 5-aminolevulinic acid. Glioblastoma tumor cells are widely infiltrative through the brain at diagnosis, and so despite a "total resection" of all obvious tumor, most people with glioblastoma later develop recurrent tumors either near the original site or at more distant "satellite lesions" within the brain. Other modalities, including radiation, are used after surgery in an effort to suppress and slow recurrent disease.
References
- ↑ 1.0 1.1 Treatment of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma