Glioblastoma multiforme natural history: Difference between revisions
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**Degree of enhancement | **Degree of enhancement | ||
**Deep location (e.g. [[thalamus]]) | **Deep location (e.g. [[thalamus]]) | ||
*With standard treatment ([[surgery]], [[radiotherapy]], and [[chemotherapy]]), the median survival is approximately 14 months.<ref>{{cite journal | author = Stupp R, Mason W, van den Bent M, Weller M, Fisher B, Taphoorn M, Belanger K, Brandes A, Marosi C, Bogdahn U, Curschmann J, Janzer R, Ludwin S, Gorlia T, Allgeier A, Lacombe D, Cairncross J, Eisenhauer E, Mirimanoff R | title = Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. | journal = N Engl J Med | volume = 352 | issue = 10 | pages = 987-96 | year = 2005 | id = PMID 15758009}}</ref> Increasing age (> 60 years) carries a worse prognosis. | |||
*With standard treatment ([[surgery]], [[radiotherapy]], and [[chemotherapy]]), the median survival is approximately 14 months.<ref>{{cite journal | author = Stupp R, Mason W, van den Bent M, Weller M, Fisher B, Taphoorn M, Belanger K, Brandes A, Marosi C, Bogdahn U, Curschmann J, Janzer R, Ludwin S, Gorlia T, Allgeier A, Lacombe D, Cairncross J, Eisenhauer E, Mirimanoff R | title = Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. | journal = N Engl J Med | volume = 352 | issue = 10 | pages = 987-96 | year = 2005 | id = PMID 15758009}}</ref> | |||
==References== | ==References== | ||
Revision as of 18:51, 16 September 2015
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Glioblastoma multiforme Microchapters |
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Glioblastoma multiforme natural history On the Web |
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Risk calculators and risk factors for Glioblastoma multiforme natural history |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Complications
Common complications of glioblastoma include:[1]
- Herniation (axial, transtentorial, subfalcine, tonsillar)
- Systemic illness
- Brainstem invasion by tumor
- Neutron-induced cerebral injury
- Weakness
- Fatigue
- Numbness
- Surgical complications (cerebral hemorrhage, edema)
- Coma
Prognosis
- Prognosis is generally poor, and the 5-year survival rate of patients with glioblastoma is approximately 10%.
- Negative prognostic factors include:[2]
- With standard treatment (surgery, radiotherapy, and chemotherapy), the median survival is approximately 14 months.[3] Increasing age (> 60 years) carries a worse prognosis.
References
- ↑ Silbergeld DL, Rostomily RC, Alvord EC (1991). "The cause of death in patients with glioblastoma is multifactorial: clinical factors and autopsy findings in 117 cases of supratentorial glioblastoma in adults". J Neurooncol. 10 (2): 179–85. PMID 1654403.
- ↑ Prognosis of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma
- ↑ Stupp R, Mason W, van den Bent M, Weller M, Fisher B, Taphoorn M, Belanger K, Brandes A, Marosi C, Bogdahn U, Curschmann J, Janzer R, Ludwin S, Gorlia T, Allgeier A, Lacombe D, Cairncross J, Eisenhauer E, Mirimanoff R (2005). "Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma". N Engl J Med. 352 (10): 987–96. PMID 15758009.