Glioblastoma multiforme classification: Difference between revisions
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==Overview== | ==Overview== | ||
Glioblastoma may be classified into several subtypes based on the origin and molecular alterations.<ref name=ddd>Classification of | Glioblastoma multiforme may be classified into several subtypes based on the origin and molecular alterations.<ref name=ddd>Classification of Glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/Glioblastoma multiforme</ref><ref name="pmid20129251">{{cite journal| author=Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD et al.| title=Integrated genomic analysis identifies clinically relevant subtypes of Glioblastoma multiforme characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. | journal=Cancer Cell | year= 2010 | volume= 17 | issue= 1 | pages= 98-110 | pmid=20129251 | doi=10.1016/j.ccr.2009.12.020 | pmc=PMC2818769 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20129251 }} </ref> | ||
==Classification== | ==Classification== | ||
Glioblastoma may be classified according to the origin into two subtypes: Primary and secondary.<ref name=ddd>Classification of | Glioblastoma multiforme may be classified according to the origin into two subtypes: Primary and secondary.<ref name=ddd>Classification of Glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/Glioblastoma multiforme</ref> | ||
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! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Subtype of | ! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Subtype of Glioblastoma multiforme}} | ||
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Characteristic features}} | ! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Characteristic features}} | ||
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:Primary glioblastoma | :Primary glioblastoma multiforme | ||
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*De novo origin | *De novo origin | ||
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:Secondary glioblastoma | :Secondary glioblastoma multiforme | ||
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*Arises from pre-existing lower grade gliomas | *Arises from pre-existing lower grade gliomas | ||
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Glioblastoma multiforme may be classified according to the molecular alterations into four subtypes:<ref name="pmid20129251">{{cite journal| author=Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD et al.| title=Integrated genomic analysis identifies clinically relevant subtypes of Glioblastoma multiforme characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. | journal=Cancer Cell | year= 2010 | volume= 17 | issue= 1 | pages= 98-110 | pmid=20129251 | doi=10.1016/j.ccr.2009.12.020 | pmc=PMC2818769 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20129251 }} </ref> | |||
Glioblastoma may be classified according to the molecular alterations into four subtypes:<ref name="pmid20129251">{{cite journal| author=Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD et al.| title=Integrated genomic analysis identifies clinically relevant subtypes of | |||
*'''Classic''' | *'''Classic''' | ||
*'''Proneural''' | *'''Proneural''' | ||
Revision as of 16:53, 18 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Glioblastoma multiforme may be classified into several subtypes based on the origin and molecular alterations.[1][2]
Classification
Glioblastoma multiforme may be classified according to the origin into two subtypes: Primary and secondary.[1]
| Subtype of Glioblastoma multiforme | Characteristic features |
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Glioblastoma multiforme may be classified according to the molecular alterations into four subtypes:[2]
- Classic
- Proneural
- Mesenchymal
- Neural
References
- ↑ 1.0 1.1 Classification of Glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/Glioblastoma multiforme
- ↑ 2.0 2.1 Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD; et al. (2010). "Integrated genomic analysis identifies clinically relevant subtypes of Glioblastoma multiforme characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1". Cancer Cell. 17 (1): 98–110. doi:10.1016/j.ccr.2009.12.020. PMC 2818769. PMID 20129251.